| UniProt ID | NNK1_YEAST | |
|---|---|---|
| UniProt AC | P36003 | |
| Protein Name | Nitrogen network kinase 1 | |
| Gene Name | NNK1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 928 | |
| Subcellular Localization | Cytoplasm . | |
| Protein Description | Serine/threonine-protein kinase involved in the phosphorylation of the NAD(+)-dependent glutamate dehydrogenase GDH2. When overexpressed, confers hypersensitivity to rapamycin and induces rapid nuclear accumulation of GLN3 to activate the transcription of nitrogen-regulated genes.. | |
| Protein Sequence | MFTSQRQLRQNGSPMSSSRSSQHSSGTASPISDSPASNRSYGRDLRGLMGIDIPANEPAFNRANSSDTIYFRPKKIYKMEHEHPSRSTLVQLQTRSQPDDVASSQVNPEGGTDDLELGDPCGNQSLYTIGAEYVPDLDFTKLVNEWQKSTEDLYEFRSSATPQVQIKDSGKGNYELWSSPDAILTQNKLRRDSFSQENSDSLSPEDSILSRNLHSKVKPIPLPRNSQQIFTPLSNLEAERRSSYTTSSNNNSITQNNKFSFAKLKYSLPTQSSAVPASFDSNASSLNFLPTTTLSTLSELQISPNDMMDLIQKLPRNFLNLPYTQRKKVIIEHAPSHDYKAMMSLVKKFMLTSSRSNFSLAGFANNASVSQATANDDNINSRNTPNNSNDTYVNTRPLQRSRHGSIASQFLSSFSPSMTSIAKMNSNPLSGSAGGSARPDDKGMEILGHRLGKIIGFGAWGIIRECFDIETGVGRVIKIVKFKGHQNIKKHVLREVAIWRTLKHNRILPLLDWKLDDNYAMYCLTERINDGTLYDLVISWDEFKRSKIPFAERCRLTIFLSLQLLSALKYMHSKTIVHGDIKLENCLLQKEGKKSDWKVFLCDFGMSCHFDEKHVYRNDTFDENLSSGNSHRKRKSIEQTNLIKYPTTNFLPDDRTNDFDASENLKYQFENRKHQPFTPKGMVSSSSHSLKHLNQPSSSSSSNLFHKPASQPQPQHRSPFHGRHKTTDFSNLEPEPSKYIGSLPYASPELLRYSDARRSKSVEMHIYDSPDSSQSEISAASSSSSNLSSLSSSTKASAVTNSGVTTSSPSGSSTDFPCIVSPLGPASDIWALGVMLYTMLVGKLPFNHEFEPRLRSLIKVGEFDRFSLAQVCKFDRKKNEGTIGQGLYDTVIGCLTIDLDKRWKLKRIEEVLQNEMNLSEAIHDNNGS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 13 | Phosphorylation | RQLRQNGSPMSSSRS HHHHHCCCCCCCCCC | 25.61 | 28889911 | |
| 20 | Phosphorylation | SPMSSSRSSQHSSGT CCCCCCCCCCCCCCC | 35.98 | 22369663 | |
| 21 | Phosphorylation | PMSSSRSSQHSSGTA CCCCCCCCCCCCCCC | 30.70 | 22369663 | |
| 24 | Phosphorylation | SSRSSQHSSGTASPI CCCCCCCCCCCCCCC | 23.87 | 22369663 | |
| 25 | Phosphorylation | SRSSQHSSGTASPIS CCCCCCCCCCCCCCC | 37.73 | 22369663 | |
| 27 | Phosphorylation | SSQHSSGTASPISDS CCCCCCCCCCCCCCC | 26.38 | 22369663 | |
| 29 | Phosphorylation | QHSSGTASPISDSPA CCCCCCCCCCCCCCC | 23.70 | 22369663 | |
| 32 | Phosphorylation | SGTASPISDSPASNR CCCCCCCCCCCCCCC | 35.11 | 22369663 | |
| 34 | Phosphorylation | TASPISDSPASNRSY CCCCCCCCCCCCCCC | 18.64 | 22369663 | |
| 37 | Phosphorylation | PISDSPASNRSYGRD CCCCCCCCCCCCCCC | 35.84 | 22369663 | |
| 65 | Phosphorylation | PAFNRANSSDTIYFR CCHHCCCCCCCEEEC | 28.71 | 22369663 | |
| 66 | Phosphorylation | AFNRANSSDTIYFRP CHHCCCCCCCEEECC | 38.28 | 22369663 | |
| 68 | Phosphorylation | NRANSSDTIYFRPKK HCCCCCCCEEECCCC | 21.37 | 22369663 | |
| 70 | Phosphorylation | ANSSDTIYFRPKKIY CCCCCCEEECCCCEE | 8.81 | 22369663 | |
| 88 | Phosphorylation | HEHPSRSTLVQLQTR CCCCCCHHEEEEECC | 29.82 | 28889911 | |
| 149 | Phosphorylation | LVNEWQKSTEDLYEF HHHHHHHCHHHHHHH | 23.17 | 22369663 | |
| 150 | Phosphorylation | VNEWQKSTEDLYEFR HHHHHHCHHHHHHHH | 40.32 | 22369663 | |
| 154 | Phosphorylation | QKSTEDLYEFRSSAT HHCHHHHHHHHHCCC | 25.91 | 20377248 | |
| 158 | Phosphorylation | EDLYEFRSSATPQVQ HHHHHHHHCCCCCEE | 29.64 | 30377154 | |
| 161 | Phosphorylation | YEFRSSATPQVQIKD HHHHHCCCCCEEECC | 19.05 | 25704821 | |
| 174 | Phosphorylation | KDSGKGNYELWSSPD CCCCCCCEEECCCCC | 22.52 | 19779198 | |
| 178 | Phosphorylation | KGNYELWSSPDAILT CCCEEECCCCCHHHH | 44.62 | 21440633 | |
| 179 | Phosphorylation | GNYELWSSPDAILTQ CCEEECCCCCHHHHC | 18.41 | 21551504 | |
| 193 | Phosphorylation | QNKLRRDSFSQENSD CCHHHCCCCCCCCCC | 25.61 | 29136822 | |
| 195 | Phosphorylation | KLRRDSFSQENSDSL HHHCCCCCCCCCCCC | 40.30 | 29136822 | |
| 199 | Phosphorylation | DSFSQENSDSLSPED CCCCCCCCCCCCHHH | 28.02 | 29136822 | |
| 201 | Phosphorylation | FSQENSDSLSPEDSI CCCCCCCCCCHHHCH | 30.48 | 22369663 | |
| 203 | Phosphorylation | QENSDSLSPEDSILS CCCCCCCCHHHCHHH | 30.14 | 22369663 | |
| 207 | Phosphorylation | DSLSPEDSILSRNLH CCCCHHHCHHHCCCC | 24.62 | 19779198 | |
| 242 | Phosphorylation | NLEAERRSSYTTSSN HCHHHHHHCCCCCCC | 33.64 | 22369663 | |
| 243 | Phosphorylation | LEAERRSSYTTSSNN CHHHHHHCCCCCCCC | 25.37 | 23749301 | |
| 244 | Phosphorylation | EAERRSSYTTSSNNN HHHHHHCCCCCCCCC | 18.45 | 23749301 | |
| 245 | Phosphorylation | AERRSSYTTSSNNNS HHHHHCCCCCCCCCC | 23.34 | 22369663 | |
| 246 | Phosphorylation | ERRSSYTTSSNNNSI HHHHCCCCCCCCCCC | 23.17 | 22369663 | |
| 247 | Phosphorylation | RRSSYTTSSNNNSIT HHHCCCCCCCCCCCC | 24.22 | 22369663 | |
| 248 | Phosphorylation | RSSYTTSSNNNSITQ HHCCCCCCCCCCCCC | 41.29 | 22369663 | |
| 252 | Phosphorylation | TTSSNNNSITQNNKF CCCCCCCCCCCCCEE | 29.18 | 23749301 | |
| 254 | Phosphorylation | SSNNNSITQNNKFSF CCCCCCCCCCCEEEE | 25.68 | 22369663 | |
| 352 | Phosphorylation | LVKKFMLTSSRSNFS HHHHHHHCCCCCCCC | 16.93 | 30377154 | |
| 353 | Phosphorylation | VKKFMLTSSRSNFSL HHHHHHCCCCCCCCE | 21.57 | 30377154 | |
| 356 | Phosphorylation | FMLTSSRSNFSLAGF HHHCCCCCCCCEEEC | 44.14 | 27017623 | |
| 384 | Phosphorylation | DNINSRNTPNNSNDT CCCCCCCCCCCCCCC | 26.70 | 30377154 | |
| 388 | Phosphorylation | SRNTPNNSNDTYVNT CCCCCCCCCCCCCCC | 42.60 | 25704821 | |
| 401 | Phosphorylation | NTRPLQRSRHGSIAS CCCCCCCCCCCCHHH | 18.70 | 28889911 | |
| 405 | Phosphorylation | LQRSRHGSIASQFLS CCCCCCCCHHHHHHH | 14.62 | 28889911 | |
| 408 | Phosphorylation | SRHGSIASQFLSSFS CCCCCHHHHHHHHCC | 21.57 | 19779198 | |
| 415 | Phosphorylation | SQFLSSFSPSMTSIA HHHHHHCCCCCCHHH | 20.29 | 28889911 | |
| 417 | Phosphorylation | FLSSFSPSMTSIAKM HHHHCCCCCCHHHHC | 33.23 | 19779198 | |
| 419 | Phosphorylation | SSFSPSMTSIAKMNS HHCCCCCCHHHHCCC | 22.71 | 28889911 | |
| 420 | Phosphorylation | SFSPSMTSIAKMNSN HCCCCCCHHHHCCCC | 16.35 | 19779198 | |
| 426 | Phosphorylation | TSIAKMNSNPLSGSA CHHHHCCCCCCCCCC | 36.00 | 22369663 | |
| 430 | Phosphorylation | KMNSNPLSGSAGGSA HCCCCCCCCCCCCCC | 31.77 | 21440633 | |
| 432 | Phosphorylation | NSNPLSGSAGGSARP CCCCCCCCCCCCCCC | 21.99 | 22369663 | |
| 436 | Phosphorylation | LSGSAGGSARPDDKG CCCCCCCCCCCCCCC | 21.86 | 22369663 | |
| 557 | Phosphorylation | FAERCRLTIFLSLQL HHHHHHHHHHHHHHH | 7.13 | 27017623 | |
| 575 | Phosphorylation | LKYMHSKTIVHGDIK HHHHHCCCEEECCCC | 31.11 | 27017623 | |
| 607 | Phosphorylation | FLCDFGMSCHFDEKH EEECCCCCCCCCCCC | 12.57 | 28889911 | |
| 620 | Phosphorylation | KHVYRNDTFDENLSS CCCCCCCCCCCCCCC | 36.21 | 30377154 | |
| 627 | Phosphorylation | TFDENLSSGNSHRKR CCCCCCCCCCCHHCC | 45.20 | 30377154 | |
| 636 | Phosphorylation | NSHRKRKSIEQTNLI CCHHCCCCCHHHCCC | 35.08 | 22369663 | |
| 640 | Phosphorylation | KRKSIEQTNLIKYPT CCCCCHHHCCCCCCC | 21.14 | 19823750 | |
| 647 | Phosphorylation | TNLIKYPTTNFLPDD HCCCCCCCCCCCCCC | 31.14 | 28889911 | |
| 648 | Phosphorylation | NLIKYPTTNFLPDDR CCCCCCCCCCCCCCC | 21.33 | 21440633 | |
| 684 | Phosphorylation | FTPKGMVSSSSHSLK CCCCCCCCCCCHHHH | 18.66 | 22369663 | |
| 685 | Phosphorylation | TPKGMVSSSSHSLKH CCCCCCCCCCHHHHH | 25.17 | 22369663 | |
| 686 | Phosphorylation | PKGMVSSSSHSLKHL CCCCCCCCCHHHHHC | 25.27 | 22369663 | |
| 687 | Phosphorylation | KGMVSSSSHSLKHLN CCCCCCCCHHHHHCC | 21.02 | 22369663 | |
| 689 | Phosphorylation | MVSSSSHSLKHLNQP CCCCCCHHHHHCCCC | 40.85 | 22369663 | |
| 697 | Phosphorylation | LKHLNQPSSSSSSNL HHHCCCCCCCCCCCC | 32.84 | 27017623 | |
| 698 | Phosphorylation | KHLNQPSSSSSSNLF HHCCCCCCCCCCCCC | 40.71 | 29136822 | |
| 699 | Phosphorylation | HLNQPSSSSSSNLFH HCCCCCCCCCCCCCC | 38.28 | 29136822 | |
| 700 | Phosphorylation | LNQPSSSSSSNLFHK CCCCCCCCCCCCCCC | 39.47 | 21440633 | |
| 701 | Phosphorylation | NQPSSSSSSNLFHKP CCCCCCCCCCCCCCC | 25.78 | 29136822 | |
| 702 | Phosphorylation | QPSSSSSSNLFHKPA CCCCCCCCCCCCCCC | 39.23 | 29136822 | |
| 710 | Phosphorylation | NLFHKPASQPQPQHR CCCCCCCCCCCCCCC | 51.42 | 29136822 | |
| 726 | Phosphorylation | PFHGRHKTTDFSNLE CCCCCCCCCCCCCCC | 26.02 | 28889911 | |
| 727 | Phosphorylation | FHGRHKTTDFSNLEP CCCCCCCCCCCCCCC | 39.59 | 28889911 | |
| 730 | Phosphorylation | RHKTTDFSNLEPEPS CCCCCCCCCCCCCHH | 43.23 | 21440633 | |
| 737 | Phosphorylation | SNLEPEPSKYIGSLP CCCCCCHHHCCCCCC | 36.11 | 22369663 | |
| 739 | Phosphorylation | LEPEPSKYIGSLPYA CCCCHHHCCCCCCCC | 18.17 | 22369663 | |
| 742 | Phosphorylation | EPSKYIGSLPYASPE CHHHCCCCCCCCCHH | 19.33 | 28889911 | |
| 745 | Phosphorylation | KYIGSLPYASPELLR HCCCCCCCCCHHHHH | 25.63 | 28889911 | |
| 747 | Phosphorylation | IGSLPYASPELLRYS CCCCCCCCHHHHHHC | 17.05 | 19779198 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NNK1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NNK1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NNK1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-65; SER-149; THR-150;SER-179; SER-415; SER-426; SER-636; SER-689; SER-737; TYR-739 ANDSER-742, AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-65, AND MASSSPECTROMETRY. | |
