RCM1_YEAST - dbPTM
RCM1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RCM1_YEAST
UniProt AC P53972
Protein Name 25S rRNA (cytosine(2278)-C(5))-methyltransferase
Gene Name RCM1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 490
Subcellular Localization Nucleus, nucleolus .
Protein Description S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 2278 (m5C2278) in 25S rRNA. Loss of m5C2278 in 25S rRNA results in anisomycin hypersensitivity..
Protein Sequence MNFYRDATWVLEDIEKEAAKERISGSMQTLVLKSCKRYKLKSNPKHIYAVLDSCWKYKPYLEKVMKKAHILEDIPKKKGKPLFSRLTLLLLCHDLLLSKQKRIQMGKHPIKDYVLKFKSPLHSEMVKLKLKLKVRELSELVLSEDISNDLPPVRWIRINPLKCHPNGETEPVLAELRKKFTLKVDKWSELVPGSIYYDEFIPNLFGIHPSDKITAHELYKHGKIIIQDRASCFPAHILNPGPSDIVIDSCSAPGNKTTHTASYIYPEPPKDNNTRIYAFEKDPERAKVLQKMIKIAGCSPNISVNVGDFTKLATPEKYKDVTCFIVDPSCSGSGIFGRKFFDSFNRRKIDDKDDDGGIVPDEQEEFIAKEELQTRLAKLSSFQFQMVKHAMSFPAAKKIVYSTCSIHAEENERVVIDLLLDKSVREWGWKVAPKREVIPSWPRRGKVEEFEEVFRDGVTYDPQQLAEGCIRALPKSDGGIGFFAVCFERD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
138PhosphorylationKLKVRELSELVLSED
HHHHHHHHHHHHCCC		30377154
143PhosphorylationELSELVLSEDISNDL
HHHHHHHCCCCCCCC		30377154
181PhosphorylationAELRKKFTLKVDKWS
HHHHHHCCEEECCHH		27017623
220AcetylationITAHELYKHGKIIIQ
CCHHHHHHCCCEEEE		22865919
281AcetylationTRIYAFEKDPERAKV
CEEEEEECCHHHHHH		24489116
343PhosphorylationFGRKFFDSFNRRKID
CCHHHHHCCCCCCCC		30377154
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RCM1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RCM1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RCM1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RT05_YEASTMRPS5physical
16554755
MED9_YEASTCSE2genetic
19061648
DUS2_YEASTSMM1genetic
19061648
MPP6_YEASTMPP6genetic
19061648
MRT4_YEASTMRT4genetic
19061648
UAF30_YEASTUAF30genetic
19061648
RS8A_YEASTRPS8Agenetic
27708008
RS8B_YEASTRPS8Agenetic
27708008
UME6_YEASTUME6genetic
27708008
HMI1_YEASTHMI1genetic
27708008
SRL4_YEASTSRL4genetic
27708008
PMA2_YEASTPMA2genetic
27708008
MDL2_YEASTMDL2genetic
27708008
BRR1_YEASTBRR1genetic
27708008
MED1_YEASTMED1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RCM1_YEAST

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Related Literatures of Post-Translational Modification

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