UAF30_YEAST - dbPTM
UAF30_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID UAF30_YEAST
UniProt AC Q08747
Protein Name Upstream activation factor subunit UAF30
Gene Name UAF30
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 228
Subcellular Localization Nucleus, nucleolus .
Protein Description Nonessential component of the UAF (upstream activation factor) complex which interacts with the upstream element of the RNA polymerase I promoter and forms a stable preinitiation complex. Together with SPT15/TBP UAF seems to stimulate basal transcription to a fully activated level. UAF30 seems to play a role in silencing transcription by RNA polymerase II..
Protein Sequence MAELNDYSTMIDILLSDMDLETVTTKKVRMALKEVYAIDVESQGKAINKLIRKHLDLVKERPRFERSLEDLLKENATLAIELTKEITVSKRSSGEEKNDSETKGTHVEKKKGTVSKSPISTRKVTLSKSLASLLGEHELTRTEVVRRLWAYIKAHNLQNPNNKKEILCDEKLELILGKSTNMFEMHKILASHMTEPKKISDCPPLIQEVRRKEKPIVSDSEQSDTKGI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
87PhosphorylationIELTKEITVSKRSSG
EEEEEEEEEECCCCC		21.5923607784
89PhosphorylationLTKEITVSKRSSGEE
EEEEEEEECCCCCCC		17.4423607784
194PhosphorylationKILASHMTEPKKISD
HHHHHHCCCCCCHHC		43.6528889911
218PhosphorylationRKEKPIVSDSEQSDT
HCCCCCCCCCCCCCC		35.8225521595
220PhosphorylationEKPIVSDSEQSDTKG
CCCCCCCCCCCCCCC		29.9917330950
223PhosphorylationIVSDSEQSDTKGI--
CCCCCCCCCCCCC--		43.1017330950
225PhosphorylationSDSEQSDTKGI----
CCCCCCCCCCC----		36.1024961812
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of UAF30_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of UAF30_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of UAF30_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RS8A_YEASTRPS8Agenetic
19061648
RS8B_YEASTRPS8Agenetic
19061648
MRM2_YEASTMRM2genetic
19061648
IF2A_YEASTSUI2genetic
19061648
URB1_YEASTURB1genetic
19061648
SKY1_YEASTSKY1genetic
19061648
FKBP_YEASTFPR1genetic
19061648
TOP1_YEASTTOP1genetic
18765638
SKI8_YEASTSKI8genetic
19547744
PFD6_YEASTYKE2genetic
19547744
NOT3_YEASTNOT3genetic
19547744
UGA4_YEASTUGA4genetic
19547744
RPD3_YEASTRPD3genetic
16648483
SHU1_YEASTSHU1genetic
21372173
SRS2_YEASTSRS2genetic
21372173
SHU1_YEASTSHU1genetic
23790361
TOP1_YEASTTOP1genetic
23790361
RMI1_YEASTRMI1genetic
23790361
TOP3_YEASTTOP3genetic
23790361
MRE11_YEASTMRE11genetic
23790361
XRS2_YEASTXRS2genetic
23790361
RAD50_YEASTRAD50genetic
23790361
RAD52_YEASTRAD52genetic
23790361
MAK16_YEASTMAK16genetic
27708008
MAK5_YEASTMAK5genetic
27708008
TAF5_YEASTTAF5genetic
27708008
TRS20_YEASTTRS20genetic
27708008
DPOD_YEASTPOL3genetic
27708008
KIN28_YEASTKIN28genetic
27708008
TCPD_YEASTCCT4genetic
27708008
TCPZ_YEASTCCT6genetic
27708008
CAB5_YEASTCAB5genetic
27708008
TCPA_YEASTTCP1genetic
27708008
ACT_YEASTACT1genetic
27708008
BRR6_YEASTBRR6genetic
27708008
PESC_YEASTNOP7genetic
27708008
SDA1_YEASTSDA1genetic
27708008
IPI1_YEASTIPI1genetic
27708008
RPF1_YEASTRPF1genetic
27708008
ARP4_YEASTARP4genetic
27708008
MAK11_YEASTMAK11genetic
27708008
SED5_YEASTSED5genetic
27708008
CFT2_YEASTCFT2genetic
27708008
GPI12_YEASTGPI12genetic
27708008
NOP2_YEASTNOP2genetic
27708008
DBP6_YEASTDBP6genetic
27708008
CH10_YEASTHSP10genetic
27708008
ULP1_YEASTULP1genetic
27708008
SEC62_YEASTSEC62genetic
27708008
POP7_YEASTPOP7genetic
27708008
FAD1_YEASTFAD1genetic
27708008
CDC53_YEASTCDC53genetic
27708008
RPN5_YEASTRPN5genetic
27708008
NHP2_YEASTNHP2genetic
27708008
CDC13_YEASTCDC13genetic
27708008
RS13_YEASTRPS13genetic
27708008
SC61G_YEASTSSS1genetic
27708008
TAF12_YEASTTAF12genetic
27708008
CDC37_YEASTCDC37genetic
27708008
ERF3_YEASTSUP35genetic
27708008
CDC1_YEASTCDC1genetic
27708008
SPC19_YEASTSPC19genetic
27708008
GPI8_YEASTGPI8genetic
27708008
FCF1_YEASTFCF1genetic
27708008
UTP5_YEASTUTP5genetic
27708008
SMT3_YEASTSMT3genetic
27708008
PSB3_YEASTPUP3genetic
27708008
RSP5_YEASTRSP5genetic
27708008
CDC4_YEASTCDC4genetic
27708008
MOB2_YEASTMOB2genetic
27708008
RPN11_YEASTRPN11genetic
27708008
PSB7_YEASTPRE4genetic
27708008
STT3_YEASTSTT3genetic
27708008
PRS8_YEASTRPT6genetic
27708008
NU145_YEASTNUP145genetic
27708008
SP105_YEASTSPC105genetic
27708008
RCC1_YEASTSRM1genetic
27708008
DBF2_YEASTDBF2genetic
27708008
DAM1_YEASTDAM1genetic
27708008
RRP41_YEASTSKI6genetic
27708008
XPO1_YEASTCRM1genetic
27708008
MPPA_YEASTMAS2genetic
27708008
RPN1_YEASTRPN1genetic
27708008
RRP3_YEASTRRP3genetic
27708008
DNA2_YEASTDNA2genetic
27708008
UTP9_YEASTUTP9genetic
27708008
NU159_YEASTNUP159genetic
27708008
PAN1_YEASTPAN1genetic
27708008
DSN1_YEASTDSN1genetic
27708008
ESS1_YEASTESS1genetic
27708008
KTHY_YEASTCDC8genetic
27708008
CDC11_YEASTCDC11genetic
27708008
ASK1_YEASTASK1genetic
27708008
MIF2_YEASTMIF2genetic
27708008
PRS7_YEASTRPT1genetic
27708008
TOR2_YEASTTOR2genetic
27708008
DAD2_YEASTDAD2genetic
27708008
DCA13_YEASTSOF1genetic
27708008
PRP19_YEASTPRP19genetic
27708008
STU2_YEASTSTU2genetic
27708008
NEP1_YEASTEMG1genetic
27708008
NMT_YEASTNMT1genetic
27708008
DBP9_YEASTDBP9genetic
27708008
GSP1_YEASTGSP1genetic
27708008
CDC25_YEASTCDC25genetic
27708008
RLA0_YEASTRPP0genetic
27708008
IMB1_YEASTKAP95genetic
27708008
PGA3_YEASTPGA3genetic
27708008
UTP15_YEASTUTP15genetic
27708008
SPC24_YEASTSPC24genetic
27708008
RRP5_YEASTRRP5genetic
27708008
RNA1_YEASTRNA1genetic
27708008
NAT10_YEASTKRE33genetic
27708008
PRP2_YEASTPRP2genetic
27708008
PSA4_YEASTPRE6genetic
27708008
NSL1_YEASTNSL1genetic
27708008
DIM1_YEASTDIM1genetic
27708008
RPN7_YEASTRPN7genetic
27708008
H3_YEASTHHT1physical
29357286
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of UAF30_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-218 AND SER-220, ANDMASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-220, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-218; SER-220 ANDSER-223, AND MASS SPECTROMETRY.

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