RS13_YEAST - dbPTM
RS13_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RS13_YEAST
UniProt AC P05756
Protein Name 40S ribosomal protein S13 {ECO:0000303|PubMed:9559554}
Gene Name RPS13 {ECO:0000303|PubMed:9559554}
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 151
Subcellular Localization Cytoplasm .
Protein Description Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel..
Protein Sequence MGRMHSAGKGISSSAIPYSRNAPAWFKLSSESVIEQIVKYARKGLTPSQIGVLLRDAHGVTQARVITGNKIMRILKSNGLAPEIPEDLYYLIKKAVSVRKHLERNRKDKDAKFRLILIESRIHRLARYYRTVAVLPPNWKYESATASALVN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
6Phosphorylation--MGRMHSAGKGISS
--CCCCCCCCCCCCC		29.4028889911
9UbiquitinationGRMHSAGKGISSSAI
CCCCCCCCCCCCCCC		53.4323749301
9AcetylationGRMHSAGKGISSSAI
CCCCCCCCCCCCCCC		53.4324489116
92-HydroxyisobutyrylationGRMHSAGKGISSSAI
CCCCCCCCCCCCCCC		53.43-
12PhosphorylationHSAGKGISSSAIPYS
CCCCCCCCCCCCCCC		27.2322369663
13PhosphorylationSAGKGISSSAIPYSR
CCCCCCCCCCCCCCC		23.1322369663
14PhosphorylationAGKGISSSAIPYSRN
CCCCCCCCCCCCCCC		24.3522369663
18PhosphorylationISSSAIPYSRNAPAW
CCCCCCCCCCCCCCH		17.7222369663
19PhosphorylationSSSAIPYSRNAPAWF
CCCCCCCCCCCCCHH		17.4422369663
27AcetylationRNAPAWFKLSSESVI
CCCCCHHHCCCHHHH		36.4424489116
27UbiquitinationRNAPAWFKLSSESVI
CCCCCHHHCCCHHHH		36.4423749301
29PhosphorylationAPAWFKLSSESVIEQ
CCCHHHCCCHHHHHH		32.4222369663
30PhosphorylationPAWFKLSSESVIEQI
CCHHHCCCHHHHHHH		44.3122369663
32PhosphorylationWFKLSSESVIEQIVK
HHHCCCHHHHHHHHH		30.2822369663
39UbiquitinationSVIEQIVKYARKGLT
HHHHHHHHHHHCCCC		34.5223749301
39AcetylationSVIEQIVKYARKGLT
HHHHHHHHHHHCCCC		34.5224489116
43UbiquitinationQIVKYARKGLTPSQI
HHHHHHHCCCCHHHH		50.5323749301
43AcetylationQIVKYARKGLTPSQI
HHHHHHHCCCCHHHH		50.5324489116
48PhosphorylationARKGLTPSQIGVLLR
HHCCCCHHHHHHHHH		29.2421440633
61PhosphorylationLRDAHGVTQARVITG
HHCCCCCCEEEEECC		22.5428889911
70UbiquitinationARVITGNKIMRILKS
EEEECCHHHHHHHHH		38.9423749301
76AcetylationNKIMRILKSNGLAPE
HHHHHHHHHCCCCCC		39.2324489116
76UbiquitinationNKIMRILKSNGLAPE
HHHHHHHHHCCCCCC		39.2323749301
77PhosphorylationKIMRILKSNGLAPEI
HHHHHHHHCCCCCCC		32.4621440633
93SuccinylationEDLYYLIKKAVSVRK
HHHHHHHHHHHHHHH		31.8923954790
93AcetylationEDLYYLIKKAVSVRK
HHHHHHHHHHHHHHH		31.8924489116
112AcetylationNRKDKDAKFRLILIE
CCCCCCCCHHHHHHH		40.9424489116
1122-HydroxyisobutyrylationNRKDKDAKFRLILIE
CCCCCCCCHHHHHHH		40.94-
120PhosphorylationFRLILIESRIHRLAR
HHHHHHHHHHHHHHH		29.5530377154
140UbiquitinationAVLPPNWKYESATAS
EECCCCCCCEECCHH		45.8617644757
140MethylationAVLPPNWKYESATAS
EECCCCCCCEECCHH		45.8620137074
147PhosphorylationKYESATASALVN---
CCEECCHHHHCC---		20.1330377154
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RS13_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RS13_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RS13_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
NAM7_YEASTNAM7physical
23801788
CDC73_YEASTCDC73genetic
27708008
SEC17_YEASTSEC17genetic
27708008
SLI15_YEASTSLI15genetic
27708008
KRR1_YEASTKRR1genetic
27708008
GPI19_YEASTGPI19genetic
27708008
UTP6_YEASTUTP6genetic
27708008
RMRP_YEASTSNM1genetic
27708008
RSP5_YEASTRSP5genetic
27708008
ACT_YEASTACT1genetic
27708008
ALG2_YEASTALG2genetic
27708008
PRP43_YEASTPRP43genetic
27708008
COPB2_YEASTSEC27genetic
27708008
PRP18_YEASTPRP18genetic
27708008
RRP3_YEASTRRP3genetic
27708008
UTP9_YEASTUTP9genetic
27708008
ATC7_YEASTNEO1genetic
27708008
RRN7_YEASTRRN7genetic
27708008
MIF2_YEASTMIF2genetic
27708008
CWC16_YEASTYJU2genetic
27708008
ABF1_YEASTABF1genetic
27708008
RRN3_YEASTRRN3genetic
27708008
SN114_YEASTSNU114genetic
27708008
COFI_YEASTCOF1genetic
27708008
RU1C_YEASTYHC1genetic
27708008
IMB1_YEASTKAP95genetic
27708008
POB3_YEASTPOB3genetic
27708008
PDS5_YEASTPDS5genetic
27708008
UTP15_YEASTUTP15genetic
27708008
RRP5_YEASTRRP5genetic
27708008
HAS1_YEASTHAS1genetic
27708008
SGT1_YEASTSGT1genetic
27708008
DED1_YEASTDED1genetic
27708008
RPA1_YEASTRPA190genetic
27708008
IPL1_YEASTIPL1genetic
27708008
BUR1_YEASTSGV1genetic
27708008
RIM15_YEASTRIM15genetic
27708008
MMS2_YEASTMMS2genetic
27708008
MON1_YEASTMON1genetic
27708008
HTD2_YEASTHTD2genetic
27708008
THP2_YEASTTHP2genetic
27708008
STB5_YEASTSTB5genetic
27708008
ALLA_YEASTDAL3genetic
27708008
VPS53_YEASTVPS53genetic
27708008
CBPS_YEASTCPS1genetic
27708008
MLP1_YEASTMLP1genetic
27708008
SIC1_YEASTSIC1genetic
27708008
SPSY_YEASTSPE4genetic
27708008
YL345_YEASTYLR345Wgenetic
27708008
SKY1_YEASTSKY1genetic
27708008
PHM7_YEASTPHM7genetic
27708008
ASE1_YEASTASE1genetic
27708008
BUD21_YEASTBUD21genetic
27708008
SUR1_YEASTSUR1genetic
27708008
AXL1_YEASTAXL1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RS13_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-12; SER-14 AND SER-32,AND MASS SPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-12 AND SER-30, AND MASSSPECTROMETRY.

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