ALG2_YEAST - dbPTM
ALG2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ALG2_YEAST
UniProt AC P43636
Protein Name Alpha-1,3/1,6-mannosyltransferase ALG2
Gene Name ALG2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 503
Subcellular Localization Endoplasmic reticulum membrane
Multi-pass membrane protein .
Protein Description Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate..
Protein Sequence MIEKDKRTIAFIHPDLGIGGAERLVVDAALGLQQQGHSVIIYTSHCDKSHCFEEVKNGQLKVEVYGDFLPTNFLGRFFIVFATIRQLYLVIQLILQKKVNAYQLIIIDQLSTCIPLLHIFSSATLMFYCHFPDQLLAQRAGLLKKIYRLPFDLIEQFSVSAADTVVVNSNFTKNTFHQTFKYLSNDPDVIYPCVDLSTIEIEDIDKKFFKTVFNEGDRFYLSINRFEKKKDVALAIKAFALSEDQINDNVKLVICGGYDERVAENVEYLKELQSLADEYELSHTTIYYQEIKRVSDLESFKTNNSKIIFLTSISSSLKELLLERTEMLLYTPAYEHFGIVPLEAMKLGKPVLAVNNGGPLETIKSYVAGENESSATGWLKPAVPIQWATAIDESRKILQNGSVNFERNGPLRVKKYFSREAMTQSFEENVEKVIWKEKKYYPWEIFGISFSNFILHMAFIKILPNNPWPFLFMATFMVLYFKNYLWGIYWAFVFALSYPYEEI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
170N-linked_GlycosylationDTVVVNSNFTKNTFH
CEEEECCCCCCCCHH		43.32-
302PhosphorylationSDLESFKTNNSKIIF
HHHHHHCCCCCEEEE		37.3117287358
303N-linked_GlycosylationDLESFKTNNSKIIFL
HHHHHCCCCCEEEEE		51.90-
306UbiquitinationSFKTNNSKIIFLTSI
HHCCCCCEEEEEEEC		41.7817644757
318UbiquitinationTSISSSLKELLLERT
EECCHHHHHHHHHHH		48.5417644757
346UbiquitinationIVPLEAMKLGKPVLA
CCCHHHHHCCCCEEE		62.2217644757
349UbiquitinationLEAMKLGKPVLAVNN
HHHHHCCCCEEEEEC		42.2517644757
364UbiquitinationGGPLETIKSYVAGEN
CCCHHHHHHHHCCCC		43.0617644757
371N-linked_GlycosylationKSYVAGENESSATGW
HHHHCCCCCCCCCCC		54.23-
396UbiquitinationTAIDESRKILQNGSV
HHCHHHHHHHHCCCC		57.9823749301
400N-linked_GlycosylationESRKILQNGSVNFER
HHHHHHHCCCCCCCC		41.06-
418PhosphorylationLRVKKYFSREAMTQS
CHHHEEECHHHHHHH		26.5627017623
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ALG2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ALG2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ALG2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MPG1_YEASTPSA1genetic
12667607
PEX29_YEASTPEX29physical
18719252
CDC53_YEASTCDC53genetic
27708008
CDC1_YEASTCDC1genetic
27708008
RPB7_YEASTRPB7genetic
27708008
FIP1_YEASTFIP1genetic
27708008
NAB3_YEASTNAB3genetic
27708008
SWC5_YEASTSWC5genetic
27708008
SDS3_YEASTSDS3genetic
27708008
UPS1_YEASTUPS1genetic
27708008
SST2_YEASTSST2genetic
27708008
SCS7_YEASTSCS7genetic
27708008
EOS1_YEASTEOS1genetic
27708008
PHO23_YEASTPHO23genetic
27708008
SIN3_YEASTSIN3genetic
27708008
GGPPS_YEASTBTS1genetic
27708008
HSP7F_YEASTSSE1genetic
27708008
YME1_YEASTYME1genetic
27708008
CDC24_YEASTCDC24genetic
27708008
STU1_YEASTSTU1genetic
27708008
KPC1_YEASTPKC1genetic
27708008
IPYR_YEASTIPP1genetic
27708008
EIF3A_YEASTRPG1genetic
27708008
CALM_YEASTCMD1genetic
27708008
TAF5_YEASTTAF5genetic
27708008
MCM7_YEASTMCM7genetic
27708008
NSE4_YEASTNSE4genetic
27708008
RPB1_YEASTRPO21genetic
27708008
FAL1_YEASTFAL1genetic
27708008
MAK21_YEASTMAK21genetic
27708008
TAF12_YEASTTAF12genetic
27708008
RIFK_YEASTFMN1genetic
27708008
FCF1_YEASTFCF1genetic
27708008
SCC4_YEASTSCC4genetic
27708008
MOB2_YEASTMOB2genetic
27708008
ACT_YEASTACT1genetic
27708008
COPD_YEASTRET2genetic
27708008
DAM1_YEASTDAM1genetic
27708008
NUP57_YEASTNUP57genetic
27708008
GPI1_YEASTGPI1genetic
27708008
XPO1_YEASTCRM1genetic
27708008
MPPA_YEASTMAS2genetic
27708008
CTF8_YEASTCTF8genetic
27708008
ATC7_YEASTNEO1genetic
27708008
RHO3_YEASTRHO3genetic
27708008
NDC80_YEASTNDC80genetic
27708008
PSB1_YEASTPRE3genetic
27708008
ARP4_YEASTARP4genetic
27708008
KTHY_YEASTCDC8genetic
27708008
ARP3_YEASTARP3genetic
27708008
CDC11_YEASTCDC11genetic
27708008
CENPA_YEASTCSE4genetic
27708008
ASK1_YEASTASK1genetic
27708008
RSC4_YEASTRSC4genetic
27708008
DCA13_YEASTSOF1genetic
27708008
CFT2_YEASTCFT2genetic
27708008
NEP1_YEASTEMG1genetic
27708008
IMB1_YEASTKAP95genetic
27708008
NSE5_YEASTNSE5genetic
27708008
UTP15_YEASTUTP15genetic
27708008
TAF7_YEASTTAF7genetic
27708008
NOP2_YEASTNOP2genetic
27708008
DCP2_YEASTDCP2genetic
27708008
CAP_YEASTSRV2genetic
27708008
CH10_YEASTHSP10genetic
27708008
SGT1_YEASTSGT1genetic
27708008
PSB2_YEASTPUP1genetic
27708008
SYA_YEASTALA1genetic
27708008
MOT1_YEASTMOT1genetic
27708008
MEX67_YEASTMEX67genetic
27708008
DIM1_YEASTDIM1genetic
27708008
IF6_YEASTTIF6genetic
27708008
PMT2_YEASTPMT2genetic
27708008
VPS10_YEASTPEP1genetic
27708008
ARL1_YEASTARL1genetic
27708008
THRC_YEASTTHR4genetic
27708008
PP2C1_YEASTPTC1genetic
27708008
GPR1_YEASTGPR1genetic
27708008
VAM6_YEASTVAM6genetic
27708008
RS16A_YEASTRPS16Bgenetic
27708008
RS16B_YEASTRPS16Bgenetic
27708008
PMT1_YEASTPMT1genetic
27708008
ACK1_YEASTACK1genetic
27708008
ARO1_YEASTARO1genetic
27708008
NBP2_YEASTNBP2genetic
27708008
CWC15_YEASTCWC15genetic
27708008
MSN5_YEASTMSN5genetic
27708008
SAC7_YEASTSAC7genetic
27708008
DOT1_YEASTDOT1genetic
27708008
VPS60_YEASTVPS60genetic
27708008
CEM1_YEASTCEM1genetic
27708008
SWI4_YEASTSWI4genetic
27708008
UBP3_YEASTUBP3genetic
27708008
BEM2_YEASTBEM2genetic
27708008
PBP1_YEASTPBP1genetic
27708008
OPI1_YEASTOPI1genetic
27708008
SLT2_YEASTSLT2genetic
27708008
NMD2_YEASTNMD2genetic
27708008
IRE1_YEASTIRE1genetic
27708008
STB5_YEASTSTB5genetic
27708008
DAL81_YEASTDAL81genetic
27708008
SYS1_YEASTSYS1genetic
27708008
VPS53_YEASTVPS53genetic
27708008
SNX4_YEASTSNX4genetic
27708008
BCK1_YEASTBCK1genetic
27708008
RPA34_YEASTRPA34genetic
27708008
VPS24_YEASTVPS24genetic
27708008
CANB_YEASTCNB1genetic
27708008
IRS4_YEASTIRS4genetic
27708008
ERG3_YEASTERG3genetic
27708008
CSF1_YEASTCSF1genetic
27708008
MMS22_YEASTMMS22genetic
27708008
RL31B_YEASTRPL31Bgenetic
27708008
VPS9_YEASTVPS9genetic
27708008
AIM34_YEASTAIM34genetic
27708008
NAM7_YEASTNAM7genetic
27708008
PKR1_YEASTPKR1genetic
27708008
MRE11_YEASTMRE11genetic
27708008
GAS1_YEASTGAS1genetic
27708008
CRZ1_YEASTCRZ1genetic
27708008
SIW14_YEASTSIW14genetic
27708008
BRE5_YEASTBRE5genetic
27708008
YN9A_YEASTYNR071Cgenetic
27708008
TLG2_YEASTTLG2genetic
27708008
CSK2C_YEASTCKB2genetic
27708008
GYP1_YEASTGYP1genetic
27708008
RAD1_YEASTRAD1genetic
27708008
ARL3_YEASTARL3genetic
27708008
SUR1_YEASTSUR1genetic
27708008
SRO7_YEASTSRO7genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ALG2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-302, AND MASSSPECTROMETRY.

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