VPS10_YEAST - dbPTM
VPS10_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID VPS10_YEAST
UniProt AC P32319
Protein Name Vacuolar protein sorting/targeting protein VPS10
Gene Name PEP1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1579
Subcellular Localization Golgi apparatus, trans-Golgi network membrane
Single-pass type I membrane protein. Prevacuolar compartment membrane
Single-pass type I membrane protein. Cycles between the Golgi apparatus and the prevacuolar compartments.
Protein Description Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A. May execute multiple rounds of sorting by cycling between the late Golgi and a prevacuolar endosome-like compartment. Binds the Golgi-modified P2 form of CPY, and this interaction is dependent on the presence of an intact CPY vacuolar protein sorting signal..
Protein Sequence MILLHFVYSLWALLLIPLTNAEEFTPKVTKTIAQDSFDILSFDDSNTLIRKQDTSVTISFDDGETWEKVEGIEGEITWIYIDPFNRHDRAVATAMNGSYLYITNDQGKSWERITLPDSGESISPRECYIETHPLNKNYFLAKCNYCEKTEVNNDNEENSGDEEGQFEIFNITRCTDKVFASNDGGKSFSEIKSSLERNENSPISISDCGFAKTSKDSDLESSDTSIICLFQNMQLIMDEFSSPYTESKLVLTTDWGKSLKEFDQFKDKVVNGYRILKSHMVVLTQGDRYNDMSSMDVWVSNDLSNFKMAYMPTQLRHSMQGEIYEDAMGRIILPMSRERSDQEEDKGIVSEILISDSQGLKFSPIPWTANEVFGYINFYQPTYLKGTMIASLYPLSRRRNRKGKAKGVKSKGVTKISVDNGLTWTMLKVVDPDNADSFDCDITDFENCSLQNMFYTREGSTPTAGILMTTGIVGDGSVFDWGDQRTFISRDGGLTWKLAFDFPCLYAVGDYGNVIVAIPYNADEDDDPQSEFYYSLDQGKTWTEYQLETTIYPNEVMNTTPDGSGAKFILNGFTLAHMDGTTNFIYAIDFSTAFNDKTCEENDFEDWNLAEGKCVNGVKYKIRRRKQDAQCLVKKVFEDLQLFETACDKCTEADYECAFEFVRDATGKCVPDYNLIVLSDVCDKTKKKTVPVKPLQLVKGDKCKKPMTVKSVDISCEGVPKKGTNDKEIVVTENKFDFKIQFYQYFDTVTDESLLMINSRGEAYISHDGGQTIKRFDSNGETIIEVVFNPYYNSSAYLFGSKGSIFSTHDRGYSFMTAKLPEARQLGMPLDFNAKAQDTFIYYGGKNCESILSPECHAVAYLTNDGGETFTEMLDNAIHCEFAGSLFKYPSNEDMVMCQVKEKSSQTRSLVSSTDFFQDDKNTVFENIIGYLSTGGYIIVAVPHENNELRAYVTIDGTEFAEAKFPYDEDVGKQEAFTILESEKGSIFLHLATNLVPGRDFGNLLKSNSNGTSFVTLEHAVNRNTFGYVDFEKIQGLEGIILTNIVSNSDKVAENKEDKQLKTKITFNEGSDWNFLKPPKRDSEGKKFSCSSKSLDECSLHLHGYTERKDIRDTYSSGSALGMMFGVGNVGPNLLPYKECSTFFTTDGGETWAEVKKTPHQWEYGDHGGILVLVPENSETDSISYSTDFGKTWKDYKFCADKVLVKDITTVPRDSALRFLLFGEAADIGGSSFRTYTIDFRNIFERQCDFDITGKESADYKYSPLGSKSNCLFGHQTEFLRKTDENCFIGNIPLSEFSRNIKNCSCTRQDFECDYNFYKANDGTCKLVKGLSPANAADVCKKEPDLIEYFESSGYRKIPLSTCEGGLKLDAPSSPHACPGKEKEFKEKYSVSAGPFAFIFISILLIIFFAAWFVYDRGIRRNGGFARFGEIRLGDDGLIENNNTDRVVNNIVKSGFYVFSNIGSLLQHTKTNIAHAISKIRGRFGNRTGPSYSSLIHDQFLDEADDLLAGHDEDANDLSSFMDQGSNFEIEEDDVPTLEEEHTSYTDQPTTTDVPDTLPEGNEENIDRPDSTAPSNENQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
96N-linked_GlycosylationRAVATAMNGSYLYIT
HHHHHEECCCEEEEE		33.52-
99PhosphorylationATAMNGSYLYITNDQ
HHEECCCEEEEECCC		12.6227017623
123PhosphorylationPDSGESISPRECYIE
CCCCCCCCCCCEEEE		27.4711875433
170N-linked_GlycosylationEGQFEIFNITRCTDK
CCCEEEEEEEEECCE		40.14-
260AcetylationTDWGKSLKEFDQFKD
CCCHHHHHHHHHHHH		64.5224489116
310PhosphorylationLSNFKMAYMPTQLRH
CCCCEEEECCHHHHH		10.5019795423
313PhosphorylationFKMAYMPTQLRHSMQ
CEEEECCHHHHHHHC		24.5719795423
410PhosphorylationGKAKGVKSKGVTKIS
CCCCCCCCCCCEEEE		32.0325704821
423PhosphorylationISVDNGLTWTMLKVV
EEECCCCEEEEEEEE		21.9327017623
425PhosphorylationVDNGLTWTMLKVVDP
ECCCCEEEEEEEECC		13.8527017623
447N-linked_GlycosylationCDITDFENCSLQNMF
CCCCCCCCCEEECEE		22.22-
708PhosphorylationDKCKKPMTVKSVDIS
CCCCCCEEEEEEEEE		33.0529136822
711PhosphorylationKKPMTVKSVDISCEG
CCCEEEEEEEEEEEC		22.2329136822
715PhosphorylationTVKSVDISCEGVPKK
EEEEEEEEEECCCCC		11.1429136822
793N-linked_GlycosylationVVFNPYYNSSAYLFG
EEEECCCCCCEEEEC		24.52-
819AcetylationGYSFMTAKLPEARQL
CCCEEEEECCHHHHH		56.2424489116
835UbiquitinationMPLDFNAKAQDTFIY
CCCCCCCCCCCEEEE		47.9217644757
846UbiquitinationTFIYYGGKNCESILS
EEEEECCCCHHHHCC		54.8017644757
1010N-linked_GlycosylationNLLKSNSNGTSFVTL
HHHCCCCCCCEEEEE		63.11-
1206AcetylationCADKVLVKDITTVPR
CCCEEEEEECCCCCC		38.9724489116
1261AcetylationGKESADYKYSPLGSK
CCCCCCCCCCCCCCC		39.5424489116
1295PhosphorylationFIGNIPLSEFSRNIK
EECCCCHHHHHCCCC		31.1028889911
1298PhosphorylationNIPLSEFSRNIKNCS
CCCHHHHHCCCCCCC		21.9928889911
1303N-linked_GlycosylationEFSRNIKNCSCTRQD
HHHCCCCCCCCCCCC		21.09-
1479AcetylationNIAHAISKIRGRFGN
HHHHHHHHHHCCCCC		30.2424489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of VPS10_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of VPS10_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of VPS10_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
VPS10_YEASTPEP1physical
14759368
DIG1_YEASTDIG1physical
11805826
NOP3_YEASTNPL3physical
11805826
VPS52_YEASTVPS52physical
10637310
VPS53_YEASTVPS53physical
10637310
VTH1_YEASTVTH1genetic
8662642
VTH2_YEASTVTH2genetic
8662642
DIG1_YEASTDIG1physical
16429126
NOP3_YEASTNPL3physical
16429126
ATC6_YEASTSPF1genetic
16269340
OSTB_YEASTWBP1genetic
16269340
ATC1_YEASTPMR1genetic
16269340
PKR1_YEASTPKR1genetic
16269340
RIC1_YEASTRIC1genetic
16269340
VPS21_YEASTVPS21genetic
16269340
AP3D_YEASTAPL5genetic
16269340
VPS35_YEASTVPS35physical
17696874
PEP8_YEASTPEP8physical
17696874
YMP0_YEASTYMR010Wphysical
18467557
VPS68_YEASTVPS68physical
18467557
VPS5_YEASTVPS5physical
18467557
ENT3_YEASTENT3physical
18467557
TVP15_YEASTTVP15physical
18467557
FTH1_YEASTFTH1physical
18467557
GGA2_YEASTGGA2physical
18467557
ATG27_YEASTATG27physical
18467557
PEP8_YEASTPEP8physical
18467557
VPS10_YEASTPEP1physical
18467557
VPS35_YEASTVPS35physical
18467557
CLH_YEASTCHC1physical
18467557
KEX1_YEASTKEX1physical
18467557
YMP0_YEASTYMR010Wphysical
22615397
VPS8_YEASTVPS8genetic
23891562
VPS38_YEASTVPS38genetic
23891562
BECN1_YEASTVPS30genetic
23891562
VPS21_YEASTVPS21genetic
23891562
ERG5_YEASTERG5genetic
23891562
AGE2_YEASTAGE2genetic
23891562
PACC_YEASTRIM101genetic
23891562
PALF_YEASTRIM8genetic
23891562
PALH_YEASTRIM21genetic
23891562
FEN1_YEASTRAD27genetic
23891562
VPS55_YEASTVPS55genetic
23891562
PFD3_YEASTPAC10genetic
23891562
PSB5_YEASTPRE2genetic
23891562
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of VPS10_YEAST

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Related Literatures of Post-Translational Modification

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