| UniProt ID | PACC_YEAST | |
|---|---|---|
| UniProt AC | P33400 | |
| Protein Name | pH-response transcription factor pacC/RIM101 | |
| Gene Name | RIM101 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 625 | |
| Subcellular Localization | Cytoplasm . Nucleus . | |
| Protein Description | Transcription factor that mediates regulation of both acid- and alkaline-expressed genes in response to ambient pH. At alkaline ambient pH, activates transcription of alkaline-expressed genes (including RIM101 itself), mainly by repressing transcriptional repressors of those genes, and represses transcription of acid-expressed genes. Required for meiosis, sporulation and invasive growth.. | |
| Protein Sequence | MVPLEDLLNKENGTAAPQHSRESIVENGTDVSNVTKKDGLPSPNLSKRSSDCSKRPRIRCTTEAIGLNGQEDERMSPGSTSSSCLPYHSTSHLNTPPYDLLGASAVSPTTSSSSDSSSSSPLAQAHNPAGDDDDADNDGDSEDITLYCKWDNCGMIFNQPELLYNHLCHDHVGRKSHKNLQLNCHWGDCTTKTEKRDHITSHLRVHVPLKPFGCSTCSKKFKRPQDLKKHLKIHLESGGILKRKRGPKWGSKRTSKKNKSCASDAVSSCSASVPSAIAGSFKSHSTSPQILPPLPVGISQHLPSQQQQRAISLNQLCSDELSQYKPVYSPQLSARLQTILPPLYYNNGSTVSQGANSRSMNVYEDGCSNKTIANATQFFTKLSRNMTNNYILQQSGGSTESSSSSGRIPVAQTSYVQPPNAPSYQSVQGGSSISATANTATYVPVRLAKYPTGPSLTEHLPPLHSNTAGGVFNRQSQYAMPHYPSVRAAPSYSSSGCSILPPLQSKIPMLPSRRTMAGGTSLKPNWEFSLNQKSCTNDIIMSKLAIEEVDDESEIEDDFVEMLGIVNIIKDYLLCCVMEDLDDEESEDKDEENAFLQESLEKLSLQNQMGTNSVRILTKYPKILV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 20 | Phosphorylation | GTAAPQHSRESIVEN CCCCCCCCHHHHHCC | 32.28 | 28889911 | |
| 42 | Phosphorylation | TKKDGLPSPNLSKRS CCCCCCCCCCCCCCC | 31.31 | 22369663 | |
| 46 | Phosphorylation | GLPSPNLSKRSSDCS CCCCCCCCCCCCCCC | 32.44 | 21440633 | |
| 76 | Phosphorylation | GQEDERMSPGSTSSS CCCCCCCCCCCCCCC | 32.12 | 28889911 | |
| 95 | Phosphorylation | HSTSHLNTPPYDLLG CCCCCCCCCCCCCCC | 31.81 | 28889911 | |
| 107 | Phosphorylation | LLGASAVSPTTSSSS CCCCCCCCCCCCCCC | 19.08 | 28889911 | |
| 120 | Phosphorylation | SSDSSSSSPLAQAHN CCCCCCCCCCHHCCC | 26.36 | 28889911 | |
| 141 | Phosphorylation | DADNDGDSEDITLYC CCCCCCCCCCEEEEE | 42.57 | 27214570 | |
| 210 | Ubiquitination | LRVHVPLKPFGCSTC EEEECCCCCCCCCCC | 32.03 | 17644757 | |
| 219 | Ubiquitination | FGCSTCSKKFKRPQD CCCCCCCCCCCCHHH | 65.46 | 17644757 | |
| 220 | Ubiquitination | GCSTCSKKFKRPQDL CCCCCCCCCCCHHHH | 39.56 | 17644757 | |
| 259 | Ubiquitination | KRTSKKNKSCASDAV CCCCCCCCCHHHHHH | 56.65 | 17644757 | |
| 282 | Ubiquitination | SAIAGSFKSHSTSPQ HHHHCCCCCCCCCCC | 49.29 | 17644757 | |
| 285 | Phosphorylation | AGSFKSHSTSPQILP HCCCCCCCCCCCCCC | 37.36 | 19779198 | |
| 286 | Phosphorylation | GSFKSHSTSPQILPP CCCCCCCCCCCCCCC | 38.72 | 19779198 | |
| 287 | Phosphorylation | SFKSHSTSPQILPPL CCCCCCCCCCCCCCC | 20.16 | 28889911 | |
| 299 | Phosphorylation | PPLPVGISQHLPSQQ CCCCCCHHHCCCHHH | 12.96 | 19779198 | |
| 304 | Phosphorylation | GISQHLPSQQQQRAI CHHHCCCHHHHHHHH | 47.16 | 28889911 | |
| 325 | Ubiquitination | SDELSQYKPVYSPQL HHHHHHCCCCCCHHH | 21.99 | 17644757 | |
| 329 | Phosphorylation | SQYKPVYSPQLSARL HHCCCCCCHHHHHHH | 13.35 | 28132839 | |
| 333 | Phosphorylation | PVYSPQLSARLQTIL CCCCHHHHHHHHHHC | 13.19 | 21440633 | |
| 370 | Ubiquitination | YEDGCSNKTIANATQ ECCCCCCCHHHHHHH | 25.64 | 17644757 | |
| 381 | Ubiquitination | NATQFFTKLSRNMTN HHHHHHHHHHHHCCC | 39.03 | 17644757 | |
| 449 | Ubiquitination | YVPVRLAKYPTGPSL EEEEEECCCCCCCCH | 57.25 | 17644757 | |
| 449 | Acetylation | YVPVRLAKYPTGPSL EEEEEECCCCCCCCH | 57.25 | 22865919 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PACC_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PACC_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PACC_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-42, AND MASSSPECTROMETRY. | |
