TGL4_YEAST - dbPTM
TGL4_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TGL4_YEAST
UniProt AC P36165
Protein Name Lipase 4
Gene Name TGL4
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 910
Subcellular Localization Lipid droplet. Membrane
Multi-pass membrane protein. Lipid particle.
Protein Description Releases specific fatty acids from neutral lipid triacylglycerols (TAG) thereby supplying fatty acids to a general acylation process. May have a specific role in sporulation..
Protein Sequence MSSKISDLTSTQNKPLLVTQQLIEKYYEQILGTSQNIIPILNPKNKFIRPSKDNSDVERVEEDAGKRLQTGKNKTTNKVNFNLDTGNEDKLDDDQETVTENENNDIEMVETDEGEDERQGSSLASKCKSFLYNVFVGNYERDILIDKVCSQKQHAMSFEEWCSAGARLDDLTGKTEWKQKLESPLYDYKLIKDLTSRMREERLNRNYAQLLYIIRTNWVRNLGNMGNVNLYRHSHVGTKYLIDEYMMESRLALESLMESDLDDSYLLGILQQTRRNIGRTALVLSGGGTFGLFHIGVLGTLFELDLLPRVISGSSAGAIVASILSVHHKEEIPVLLNHILDKEFNIFKDDKQKSESENLLIKISRFFKNGTWFDNKHLVNTMIEFLGDLTFREAYNRTGKILNITVSPASLFEQPRLLNNLTAPNVLIWSAVCASCSLPGIFPSSPLYEKDPKTGERKPWTGSSSVKFVDGSVDNDLPISRLSEMFNVDHIIACQVNIHVFPFLKLSLSCVGGEIEDEFSARLKQNLSSIYNFMANEAIHILEIGSEMGIAKNALTKLRSVLSQQYSGDITILPDMCMLFRIKELLSNPTKEFLLREITNGAKATWPKVSIIQNHCGQEFALDKAISYIKGRMIVTSSLKTPFQFADSVIGLIKAPEQTSDESKNPENSTLLTRTPTKGDNHISNVLDDNLLESESTNSLLLLRENASTYGRSPSGFRPRYSITSASLNPRHQRRKSDTISTSRRPAKSFSFSVASPTSRMLRQSSKINGHPPPILQKKTSMGRLMFPMDAKTYDPESHELIPHSASIETPAMVDKKLHFGRKSRYLRHMNKKWVSSSNILYTDSDKEDHPTLRLISNFDSDAMIHSDLAGNFRRHSIDGRPPSQATKSSPFRSRPSSSTQHKSTTSFTQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
6Phosphorylation--MSSKISDLTSTQN
--CCCCHHCCCCCCC		30.2430377154
9PhosphorylationSSKISDLTSTQNKPL
CCCHHCCCCCCCCCC		34.4230377154
10PhosphorylationSKISDLTSTQNKPLL
CCHHCCCCCCCCCCH		34.9830377154
51PhosphorylationKNKFIRPSKDNSDVE
CCCCCCCCCCCCCCH		42.6721440633
55PhosphorylationIRPSKDNSDVERVEE
CCCCCCCCCCHHHHH		53.8425521595
99PhosphorylationDDDQETVTENENNDI
CCCCCCCCCCCCCCE		40.2821551504
111PhosphorylationNDIEMVETDEGEDER
CCEEEEECCCCCCHH		28.1329734811
174UbiquitinationRLDDLTGKTEWKQKL
CHHHCCCCCHHHHHH		37.7323749301
183PhosphorylationEWKQKLESPLYDYKL
HHHHHHCCCCCCHHH		30.5528889911
186PhosphorylationQKLESPLYDYKLIKD
HHHCCCCCCHHHHHH		22.1728889911
188PhosphorylationLESPLYDYKLIKDLT
HCCCCCCHHHHHHHH		8.3028889911
407PhosphorylationKILNITVSPASLFEQ
CEEEEEECHHHHHCC		13.1928889911
410PhosphorylationNITVSPASLFEQPRL
EEEECHHHHHCCHHH		36.6528889911
464PhosphorylationRKPWTGSSSVKFVDG
CCCCCCCCCEEECCC		40.2630377154
599PhosphorylationEFLLREITNGAKATW
HHHHHHHHCCCCCCC		23.8919779198
640UbiquitinationMIVTSSLKTPFQFAD
EEEECCCCCCCHHHH		56.9817644757
648PhosphorylationTPFQFADSVIGLIKA
CCCHHHHHHHHHEEC		16.5321440633
654UbiquitinationDSVIGLIKAPEQTSD
HHHHHHEECCCCCCC		64.0317644757
660PhosphorylationIKAPEQTSDESKNPE
EECCCCCCCCCCCCC		38.7928889911
664UbiquitinationEQTSDESKNPENSTL
CCCCCCCCCCCCCCC		74.5823749301
669PhosphorylationESKNPENSTLLTRTP
CCCCCCCCCCCCCCC		20.8319779198
670PhosphorylationSKNPENSTLLTRTPT
CCCCCCCCCCCCCCC		37.0525521595
673PhosphorylationPENSTLLTRTPTKGD
CCCCCCCCCCCCCCC		35.2921440633
675PhosphorylationNSTLLTRTPTKGDNH
CCCCCCCCCCCCCCC		30.0320377248
677PhosphorylationTLLTRTPTKGDNHIS
CCCCCCCCCCCCCHH		47.2324961812
684PhosphorylationTKGDNHISNVLDDNL
CCCCCCHHHCCCCCC		17.2119779198
694PhosphorylationLDDNLLESESTNSLL
CCCCCCCCCCCCCEE		36.5022369663
696PhosphorylationDNLLESESTNSLLLL
CCCCCCCCCCCEEEE		42.0122369663
697PhosphorylationNLLESESTNSLLLLR
CCCCCCCCCCEEEEE		25.4422369663
699PhosphorylationLESESTNSLLLLREN
CCCCCCCCEEEEECC		22.0822369663
713PhosphorylationNASTYGRSPSGFRPR
CHHHCCCCCCCCCCC		21.0323749301
715PhosphorylationSTYGRSPSGFRPRYS
HHCCCCCCCCCCCCE		52.3823749301
721PhosphorylationPSGFRPRYSITSASL
CCCCCCCCEEECCCC		13.7028889911
722PhosphorylationSGFRPRYSITSASLN
CCCCCCCEEECCCCC		22.2223749301
724PhosphorylationFRPRYSITSASLNPR
CCCCCEEECCCCCHH		16.5830377154
725PhosphorylationRPRYSITSASLNPRH
CCCCEEECCCCCHHH		17.7527214570
727PhosphorylationRYSITSASLNPRHQR
CCEEECCCCCHHHHC		28.5730377154
737PhosphorylationPRHQRRKSDTISTSR
HHHHCCCCCCCCCCC		37.8725533186
739PhosphorylationHQRRKSDTISTSRRP
HHCCCCCCCCCCCCC		24.7428132839
741PhosphorylationRRKSDTISTSRRPAK
CCCCCCCCCCCCCCC		23.5627717283
742PhosphorylationRKSDTISTSRRPAKS
CCCCCCCCCCCCCCC		23.5427717283
743PhosphorylationKSDTISTSRRPAKSF
CCCCCCCCCCCCCCC		21.3627717283
749PhosphorylationTSRRPAKSFSFSVAS
CCCCCCCCCCEEECC		28.3821440633
751PhosphorylationRRPAKSFSFSVASPT
CCCCCCCCEEECCCC		24.5722369663
753PhosphorylationPAKSFSFSVASPTSR
CCCCCCEEECCCCHH		18.6422369663
756PhosphorylationSFSFSVASPTSRMLR
CCCEEECCCCHHHHH		26.9322369663
758PhosphorylationSFSVASPTSRMLRQS
CEEECCCCHHHHHHH		26.8622369663
759PhosphorylationFSVASPTSRMLRQSS
EEECCCCHHHHHHHH		21.0522369663
765PhosphorylationTSRMLRQSSKINGHP
CHHHHHHHHHHCCCC		27.4524961812
766PhosphorylationSRMLRQSSKINGHPP
HHHHHHHHHHCCCCC		29.2621440633
780PhosphorylationPPILQKKTSMGRLMF
CCCCCCCCCCCCEEC		30.8621440633
781PhosphorylationPILQKKTSMGRLMFP
CCCCCCCCCCCEECC		28.2820377248
836PhosphorylationHMNKKWVSSSNILYT
HCCCCCCCCCCEEEC		27.2522369663
837PhosphorylationMNKKWVSSSNILYTD
CCCCCCCCCCEEECC		20.1322369663
838PhosphorylationNKKWVSSSNILYTDS
CCCCCCCCCEEECCC		22.0022369663
842PhosphorylationVSSSNILYTDSDKED
CCCCCEEECCCCCCC		12.5228889911
845PhosphorylationSNILYTDSDKEDHPT
CCEEECCCCCCCCCC		42.6628889911
861PhosphorylationRLISNFDSDAMIHSD
EEEECCCCCCEEECH		24.1121551504
877PhosphorylationAGNFRRHSIDGRPPS
CCCCCCCCCCCCCCC		22.1429136822
889PhosphorylationPPSQATKSSPFRSRP
CCCCCCCCCCCCCCC		38.6028889911
890PhosphorylationPSQATKSSPFRSRPS
CCCCCCCCCCCCCCC		29.6117287358
894PhosphorylationTKSSPFRSRPSSSTQ
CCCCCCCCCCCCCCC		49.2619823750
897PhosphorylationSPFRSRPSSSTQHKS
CCCCCCCCCCCCCCC		35.4919823750
898PhosphorylationPFRSRPSSSTQHKST
CCCCCCCCCCCCCCC		39.8419823750
899PhosphorylationFRSRPSSSTQHKSTT
CCCCCCCCCCCCCCC		36.1019823750
900PhosphorylationRSRPSSSTQHKSTTS
CCCCCCCCCCCCCCC		36.3219823750
904PhosphorylationSSSTQHKSTTSFTQ-
CCCCCCCCCCCCCC-		34.4921440633
907PhosphorylationTQHKSTTSFTQ----
CCCCCCCCCCC----		26.7828889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
675TPhosphorylationKinaseCDK1P00546
Uniprot
890SPhosphorylationKinaseCDK1P00546
Uniprot
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference
675TPhosphorylation

19150427
890SPhosphorylation

19150427
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TGL4_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ENG2_YEASTACF2physical
18467557
TGL3_YEASTTGL3genetic
19150427
ERT1_YEASTERT1genetic
20093466
SGF29_YEASTSGF29genetic
20093466
SLX5_YEASTSLX5genetic
20093466
RLA4_YEASTRPP2Bgenetic
20093466
DOT1_YEASTDOT1genetic
20093466
APT2_YEASTAPT2genetic
20093466
SLX8_YEASTSLX8genetic
20093466
YOR1_YEASTYOR1genetic
20093466
SNF6_YEASTSNF6genetic
20093466
PTH_YEASTPTH1genetic
20093466
HPM1_YEASTHPM1genetic
20093466
APQ12_YEASTAPQ12genetic
20093466
SMA2_YEASTSMA2genetic
20093466
PP2A4_YEASTPPG1genetic
20093466
IRA2_YEASTIRA2genetic
20093466
PMG3_YEASTGPM3genetic
20093466
EF1G1_YEASTCAM1genetic
20093466
SWE1_YEASTSWE1genetic
25713391
CDK1_YEASTCDC28genetic
25713391
2ABA_YEASTCDC55genetic
25713391
RTG3_YEASTRTG3genetic
27708008
ERT1_YEASTERT1genetic
27708008
SGF29_YEASTSGF29genetic
27708008
SLX5_YEASTSLX5genetic
27708008
MAF1_YEASTMAF1genetic
27708008
SWF1_YEASTSWF1genetic
27708008
RLA4_YEASTRPP2Bgenetic
27708008
DOT1_YEASTDOT1genetic
27708008
APT2_YEASTAPT2genetic
27708008
YOR1_YEASTYOR1genetic
27708008
PTH_YEASTPTH1genetic
27708008
HPM1_YEASTHPM1genetic
27708008
SDHA_YEASTSDH1genetic
27708008
MMM1_YEASTMMM1genetic
27708008
PP2A4_YEASTPPG1genetic
27708008
MDM12_YEASTMDM12genetic
27708008
PMG3_YEASTGPM3genetic
27708008
MCH5_YEASTMCH5genetic
27708008
EF1G1_YEASTCAM1genetic
27708008
HSP7F_YEASTSSE1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TGL4_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-55; THR-675; SER-737;SER-751; SER-756 AND SER-836, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-737, AND MASSSPECTROMETRY.
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-781 AND SER-890, ANDMASS SPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-751, AND MASSSPECTROMETRY.

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