| UniProt ID | SLX8_YEAST | |
|---|---|---|
| UniProt AC | P40072 | |
| Protein Name | E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX8 | |
| Gene Name | SLX8 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 274 | |
| Subcellular Localization | Nucleus, nucleolus . Localizes at the replication centers. | |
| Protein Description | Mediates ubiquitination and subsequent desumoylation/degradation of sumoylated proteins and proteins containing SUMO-like domains. Promotes UBC4-dependent ubiquitination that mediates the proteolytic down-regulation of sumoylated proteins. Involved in the stimulation of ubiquitin conjugating enzymes, including UBC1, UBC4, UBC5 and UBC13-MMS2. Acts as a critical suppressor of gross chromosomal rearrangements (GCRs) during normal cell cycle progression. Has a role in localizing the DNA damage protein DCD2. Involved in stabilizing, restarting or resolving transiently stalled replication forks. Prevents accumulation of DNA damage during cell cycle progression. Inhibits RAD51-independent recombination via modulating the sumoylation of DNA repair proteins.. | |
| Protein Sequence | MARRPDNQNPEGENLRIKRVRLESVRQNDEEEENEVSRTQNIVTDNRHDSPEAVVEIIGERALENTSEEDGDDDLSLFRALEEDPGSDHNTSNNDSGNHDRETMHTEEPEASSGNNITLTNNVEELHTMDVLSQTANTPSASPMLDAAPPTTKPGTNSKEQTVDLTADAIDLDAEEQQVLQISDDDFQEETKEAPKEYGAAKDYRCPICFEPPETALMTLCGHVFCCPCLFQMVNSSRTCRQFGHCALCRSKVYLKDVRLIILRKKQVKKKVKS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 24 | Phosphorylation | IKRVRLESVRQNDEE EEEEEEHHHHCCCHH | 27.47 | 28889911 | |
| 39 | Phosphorylation | EENEVSRTQNIVTDN HHHHHHHHHCCCCCC | 20.61 | 22369663 | |
| 44 | Phosphorylation | SRTQNIVTDNRHDSP HHHHCCCCCCCCCCH | 24.61 | 22369663 | |
| 50 | Phosphorylation | VTDNRHDSPEAVVEI CCCCCCCCHHHHHHH | 20.65 | 22369663 | |
| 66 | Phosphorylation | GERALENTSEEDGDD HHHHHHCCCCCCCCC | 28.30 | 22369663 | |
| 67 | Phosphorylation | ERALENTSEEDGDDD HHHHHCCCCCCCCCC | 51.04 | 22369663 | |
| 76 | Phosphorylation | EDGDDDLSLFRALEE CCCCCCHHHHHHHHC | 32.24 | 22890988 | |
| 87 | Phosphorylation | ALEEDPGSDHNTSNN HHHCCCCCCCCCCCC | 40.87 | 25005228 | |
| 91 | Phosphorylation | DPGSDHNTSNNDSGN CCCCCCCCCCCCCCC | 29.43 | 28132839 | |
| 92 | Phosphorylation | PGSDHNTSNNDSGNH CCCCCCCCCCCCCCC | 38.66 | 19795423 | |
| 96 | Phosphorylation | HNTSNNDSGNHDRET CCCCCCCCCCCCCCC | 43.55 | 30377154 | |
| 237 | Phosphorylation | LFQMVNSSRTCRQFG HHHHHHCCCCHHHCC | 26.80 | 21440633 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SLX8_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SLX8_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SLX8_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-50, AND MASSSPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-50; THR-66 AND SER-67,AND MASS SPECTROMETRY. | |
