| UniProt ID | KAR9_YEAST | |
|---|---|---|
| UniProt AC | P32526 | |
| Protein Name | Karyogamy protein KAR9 | |
| Gene Name | KAR9 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 644 | |
| Subcellular Localization | Nucleus. Cytoplasm, cytoskeleton. Localizes to the tip of shmoo projections and to the tip of budding cells in a cell-cycle dependent manner. | |
| Protein Description | Involved in karyogamy. Component of a cortical adaptor complex that orients cytoplasmic microtubules. It may be involved in anchoring cytoplasmic microtubules to the cell cortex.. | |
| Protein Sequence | MDNDGPRSMTIGDDFQENFCERLERIHNTLHSINDCNSLNESTTSISETLLVQFYDDLENVASVIPDLVNKKRLGKDDILLFMDWLLLKKYMLYQFISDVHNIEEGFAHLLDLLEDEFSKDDQDSDKYNRFSPMFDVIEESTQIKTQLEPWLTNLKELLDTSLEFNEISKDHMDTLHKIINSNISYCLEIQEERFASPIRHTPSFTLEQLVKLLGTHTETTEPKVPKFSPAEDILSRKFLNLKKNIPPIEKSLTDILPQRIVQFGHRNITNITTLQTILQKKYELIMKDYRFMNSEFRELKVELIDKRWNILFINLNHELLYILDEIERLQSKLLTTKYTKDITIRLERQLERKSKTVSKTFNIIYRALEFSLLDAGVASKTNELAQRWLNIKPTADKILIKSSASNKIATSKKKIPKPKSLGFGRPNSVIGTITQDFQERVAINEGDSNKTPENSTTVALKGKKLGKALLQKMNIKPATSPNSSNAINPFFDPESPNKGKLILSSVPPLPYDETDETTLRVSRGENEKSPDSFITSRHENKVQITETPLMAKNKSVLDIEKDKWNHYRSLPSRIPIYKDKVVKVTVENTPIAKVFQTPPTKITTPNSQVWVPSTRRRTRLRPPTPLSQLLSPREGRLDKTPTY | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 197 | Phosphorylation | IQEERFASPIRHTPS CCHHHCCCCCCCCCC | 20.39 | 18832349 | |
| 252 | Phosphorylation | NIPPIEKSLTDILPQ CCCCCHHHHHHHHHH | 24.58 | 28889911 | |
| 301 | Sumoylation | NSEFRELKVELIDKR CHHHHHHHHHHHHCC | 28.98 | - | |
| 333 | Sumoylation | EIERLQSKLLTTKYT HHHHHHHHHHCCCCC | 34.26 | - | |
| 381 | Sumoylation | LDAGVASKTNELAQR HHHCCCHHHHHHHHH | 45.70 | - | |
| 449 | Phosphorylation | VAINEGDSNKTPENS HEECCCCCCCCCCCC | 51.59 | 21440633 | |
| 452 | Phosphorylation | NEGDSNKTPENSTTV CCCCCCCCCCCCCEE | 39.83 | 21082442 | |
| 480 | Phosphorylation | KMNIKPATSPNSSNA HCCCCCCCCCCCCCC | 53.92 | 23749301 | |
| 481 | Phosphorylation | MNIKPATSPNSSNAI CCCCCCCCCCCCCCC | 24.96 | 20377248 | |
| 484 | Phosphorylation | KPATSPNSSNAINPF CCCCCCCCCCCCCCC | 28.49 | 21440633 | |
| 485 | Phosphorylation | PATSPNSSNAINPFF CCCCCCCCCCCCCCC | 36.60 | 21440633 | |
| 496 | Phosphorylation | NPFFDPESPNKGKLI CCCCCCCCCCCCCEE | 38.88 | 19823750 | |
| 529 | Sumoylation | VSRGENEKSPDSFIT ECCCCCCCCCCCCCC | 78.02 | - | |
| 530 | Phosphorylation | SRGENEKSPDSFITS CCCCCCCCCCCCCCC | 27.97 | 25752575 | |
| 537 | Phosphorylation | SPDSFITSRHENKVQ CCCCCCCCCCCCCEE | 27.16 | 30377154 | |
| 548 | Phosphorylation | NKVQITETPLMAKNK CCEEECCCCCCCCCC | 17.05 | 20377248 | |
| 586 | Phosphorylation | KDKVVKVTVENTPIA CCCEEEEEEECCCCC | 19.18 | 21440633 | |
| 590 | Phosphorylation | VKVTVENTPIAKVFQ EEEEEECCCCCEEEC | 11.54 | 21440633 | |
| 598 | Phosphorylation | PIAKVFQTPPTKITT CCCEEECCCCCCCCC | 21.55 | 21440633 | |
| 601 | Phosphorylation | KVFQTPPTKITTPNS EEECCCCCCCCCCCC | 35.96 | 21440633 | |
| 604 | Phosphorylation | QTPPTKITTPNSQVW CCCCCCCCCCCCCCC | 37.44 | 30377154 | |
| 605 | Phosphorylation | TPPTKITTPNSQVWV CCCCCCCCCCCCCCC | 24.76 | 23749301 | |
| 608 | Phosphorylation | TKITTPNSQVWVPST CCCCCCCCCCCCCCC | 27.58 | 30377154 | |
| 614 | Phosphorylation | NSQVWVPSTRRRTRL CCCCCCCCCCCCCCC | 25.56 | 23749301 | |
| 615 | Phosphorylation | SQVWVPSTRRRTRLR CCCCCCCCCCCCCCC | 23.33 | 23749301 | |
| 625 | Phosphorylation | RTRLRPPTPLSQLLS CCCCCCCCCHHHHCC | 39.27 | 22369663 | |
| 628 | Phosphorylation | LRPPTPLSQLLSPRE CCCCCCHHHHCCCCC | 21.71 | 22369663 | |
| 632 | Phosphorylation | TPLSQLLSPREGRLD CCHHHHCCCCCCCCC | 30.42 | 22369663 | |
| 641 | Phosphorylation | REGRLDKTPTY---- CCCCCCCCCCC---- | 22.11 | 23749301 | |
| 643 | Phosphorylation | GRLDKTPTY------ CCCCCCCCC------ | 47.28 | 27017623 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of KAR9_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of KAR9_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of KAR9_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-452, AND MASSSPECTROMETRY. | |
