| UniProt ID | UBC1_YEAST | |
|---|---|---|
| UniProt AC | P21734 | |
| Protein Name | Ubiquitin-conjugating enzyme E2 1 | |
| Gene Name | UBC1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 215 | |
| Subcellular Localization | ||
| Protein Description | Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in degradation of misfolded or regulated proteins localized in the endoplasmic reticulum (ER) lumen or membrane via the ubiquitin-proteasome system. Cognate E2 conjugating enzyme for the HRD1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolded transmembrane domains (ERAD-M).. | |
| Protein Sequence | MSRAKRIMKEIQAVKDDPAAHITLEFVSESDIHHLKGTFLGPPGTPYEGGKFVVDIEVPMEYPFKPPKMQFDTKVYHPNISSVTGAICLDILKNAWSPVITLKSALISLQALLQSPEPNDPQDAEVAQHYLRDRESFNKTAALWTRLYASETSNGQKGNVEESDLYGIDHDLIDEFESQGFEKDKIVEVLRRLGVKSLDPNDNNTANRIIEELLK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 45 | Phosphorylation | TFLGPPGTPYEGGKF CEECCCCCCCCCCEE | 28.59 | 28132839 | |
| 93 | Ubiquitination | AICLDILKNAWSPVI HHHHHHHHHCCCCCH | 44.98 | 23749301 | |
| 139 | Ubiquitination | RDRESFNKTAALWTR HCHHHHHHHHHHHHH | 37.21 | 23749301 | |
| 139 | Acetylation | RDRESFNKTAALWTR HCHHHHHHHHHHHHH | 37.21 | 24489116 | |
| 150 | Phosphorylation | LWTRLYASETSNGQK HHHHHHHHCCCCCCC | 28.05 | 30377154 | |
| 152 | Phosphorylation | TRLYASETSNGQKGN HHHHHHCCCCCCCCC | 25.62 | 30377154 | |
| 157 | Ubiquitination | SETSNGQKGNVEESD HCCCCCCCCCCCHHH | 54.58 | 24961812 | |
| 196 | Ubiquitination | VLRRLGVKSLDPNDN HHHHCCCCCCCCCCC | 43.43 | 23749301 | |
| 197 | Phosphorylation | LRRLGVKSLDPNDNN HHHCCCCCCCCCCCH | 35.28 | 28132839 | |
| 205 | Phosphorylation | LDPNDNNTANRIIEE CCCCCCHHHHHHHHH | 31.40 | 22369663 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of UBC1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of UBC1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of UBC1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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