UBA1_YEAST - dbPTM
UBA1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID UBA1_YEAST
UniProt AC P22515
Protein Name Ubiquitin-activating enzyme E1 1
Gene Name UBA1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1024
Subcellular Localization Cytoplasm. Nucleus.
Protein Description Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP..
Protein Sequence MSSNNSGLSAAGEIDESLYSRQLYVLGKEAMLKMQTSNVLILGLKGLGVEIAKNVVLAGVKSMTVFDPEPVQLADLSTQFFLTEKDIGQKRGDVTRAKLAELNAYVPVNVLDSLDDVTQLSQFQVVVATDTVSLEDKVKINEFCHSSGIRFISSETRGLFGNTFVDLGDEFTVLDPTGEEPRTGMVSDIEPDGTVTMLDDNRHGLEDGNFVRFSEVEGLDKLNDGTLFKVEVLGPFAFRIGSVKEYGEYKKGGIFTEVKVPRKISFKSLKQQLSNPEFVFSDFAKFDRAAQLHLGFQALHQFAVRHNGELPRTMNDEDANELIKLVTDLSVQQPEVLGEGVDVNEDLIKELSYQARGDIPGVVAFFGGLVAQEVLKACSGKFTPLKQFMYFDSLESLPDPKNFPRNEKTTQPVNSRYDNQIAVFGLDFQKKIANSKVFLVGSGAIGCEMLKNWALLGLGSGSDGYIVVTDNDSIEKSNLNRQFLFRPKDVGKNKSEVAAEAVCAMNPDLKGKINAKIDKVGPETEEIFNDSFWESLDFVTNALDNVDARTYVDRRCVFYRKPLLESGTLGTKGNTQVIIPRLTESYSSSRDPPEKSIPLCTLRSFPNKIDHTIAWAKSLFQGYFTDSAENVNMYLTQPNFVEQTLKQSGDVKGVLESISDSLSSKPHNFEDCIKWARLEFEKKFNHDIKQLLFNFPKDAKTSNGEPFWSGAKRAPTPLEFDIYNNDHFHFVVAGASLRAYNYGIKSDDSNSKPNVDEYKSVIDHMIIPEFTPNANLKIQVNDDDPDPNANAANGSDEIDQLVSSLPDPSTLAGFKLEPVDFEKDDDTNHHIEFITACSNCRAQNYFIETADRQKTKFIAGRIIPAIATTTSLVTGLVNLELYKLIDNKTDIEQYKNGFVNLALPFFGFSEPIASPKGEYNNKKYDKIWDRFDIKGDIKLSDLIEHFEKDEGLEITMLSYGVSLLYASFFPPKKLKERLNLPITQLVKLVTKKDIPAHVSTMILEICADDKEGEDVEVPFITIHL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MSSNNSGLS
------CCCCCCCCC		53.7522814378
2Phosphorylation------MSSNNSGLS
------CCCCCCCCC		53.7530377154
3Phosphorylation-----MSSNNSGLSA
-----CCCCCCCCCC		52.4619779198
6Phosphorylation--MSSNNSGLSAAGE
--CCCCCCCCCCCCC		45.4130377154
9PhosphorylationSSNNSGLSAAGEIDE
CCCCCCCCCCCCCCH		21.4330377154
17PhosphorylationAAGEIDESLYSRQLY
CCCCCCHHHHHCHHH		28.9428889911
19PhosphorylationGEIDESLYSRQLYVL
CCCCHHHHHCHHHHH		15.8728132839
20PhosphorylationEIDESLYSRQLYVLG
CCCHHHHHCHHHHHC		20.8819779198
24PhosphorylationSLYSRQLYVLGKEAM
HHHHCHHHHHCHHHH		5.8128132839
28UbiquitinationRQLYVLGKEAMLKMQ
CHHHHHCHHHHHHHH		37.8323749301
28AcetylationRQLYVLGKEAMLKMQ
CHHHHHCHHHHHHHH		37.8324489116
36PhosphorylationEAMLKMQTSNVLILG
HHHHHHHHCCEEEEE		20.8321440633
53UbiquitinationGLGVEIAKNVVLAGV
HHCHHHHHHHHEECC		56.8023749301
139UbiquitinationVSLEDKVKINEFCHS
CCHHHHHCCCHHHHH		45.6217644757
183PhosphorylationPTGEEPRTGMVSDIE
CCCCCCCCCCCEEEC		40.1022369663
187PhosphorylationEPRTGMVSDIEPDGT
CCCCCCCEEECCCCC		24.7922369663
194PhosphorylationSDIEPDGTVTMLDDN
EEECCCCCEEEECCC		21.8622369663
196PhosphorylationIEPDGTVTMLDDNRH
ECCCCCEEEECCCCC		16.3222369663
221AcetylationSEVEGLDKLNDGTLF
EEEECCCCCCCCCEE		54.9924489116
242PhosphorylationPFAFRIGSVKEYGEY
CEEEEECCCHHCCCC		27.8721440633
244AcetylationAFRIGSVKEYGEYKK
EEEECCCHHCCCCCC		47.0922865919
250UbiquitinationVKEYGEYKKGGIFTE
CHHCCCCCCCCCEEE		40.4117644757
250SuccinylationVKEYGEYKKGGIFTE
CHHCCCCCCCCCEEE		40.4123954790
251UbiquitinationKEYGEYKKGGIFTEV
HHCCCCCCCCCEEEE		62.5617644757
256PhosphorylationYKKGGIFTEVKVPRK
CCCCCCEEEEECCCE		37.6421440633
259UbiquitinationGGIFTEVKVPRKISF
CCCEEEEECCCEECH		40.0517644757
265PhosphorylationVKVPRKISFKSLKQQ
EECCCEECHHHHHHH		29.6520377248
268PhosphorylationPRKISFKSLKQQLSN
CCEECHHHHHHHHCC		38.5021440633
270UbiquitinationKISFKSLKQQLSNPE
EECHHHHHHHHCCCC		42.9924961812
274PhosphorylationKSLKQQLSNPEFVFS
HHHHHHHCCCCCCCC		46.1021551504
285UbiquitinationFVFSDFAKFDRAAQL
CCCCCHHHHHHHHHH		48.0317644757
324UbiquitinationEDANELIKLVTDLSV
HHHHHHHHHHHHCCC		49.9117644757
376UbiquitinationLVAQEVLKACSGKFT
HHHHHHHHHCCCCCC		53.1522817900
381AcetylationVLKACSGKFTPLKQF
HHHHCCCCCCCHHHH		29.7625381059
381UbiquitinationVLKACSGKFTPLKQF
HHHHCCCCCCCHHHH		29.7623749301
386UbiquitinationSGKFTPLKQFMYFDS
CCCCCCHHHHHHHCC		42.5722817900
390PhosphorylationTPLKQFMYFDSLESL
CCHHHHHHHCCHHCC		12.9127017623
396PhosphorylationMYFDSLESLPDPKNF
HHHCCHHCCCCCCCC		50.9627017623
408UbiquitinationKNFPRNEKTTQPVNS
CCCCCCCCCCCCCCC		61.4923749301
430AcetylationVFGLDFQKKIANSKV
EEEEEHHHHHCCCEE		46.2524489116
447GlutathionylationVGSGAIGCEMLKNWA
ECCCHHHHHHHHCEE		1.9622833525
460PhosphorylationWALLGLGSGSDGYIV
EEEEECCCCCCCEEE		39.9219779198
462PhosphorylationLLGLGSGSDGYIVVT
EEECCCCCCCEEEEC		29.5619779198
473PhosphorylationIVVTDNDSIEKSNLN
EEECCCCCCCCCCCC		38.6119779198
488AcetylationRQFLFRPKDVGKNKS
CCCCCCCHHCCCCHH		61.8724489116
494UbiquitinationPKDVGKNKSEVAAEA
CHHCCCCHHHHHHHH		52.0223749301
561UbiquitinationRRCVFYRKPLLESGT
CCEEEEECCCHHCCC		28.7423749301
572UbiquitinationESGTLGTKGNTQVII
HCCCCCCCCCCEEEE		48.6523749301
575PhosphorylationTLGTKGNTQVIIPRL
CCCCCCCCEEEECCC		32.6422369663
585PhosphorylationIIPRLTESYSSSRDP
EECCCCCCCCCCCCC		25.6930377154
588PhosphorylationRLTESYSSSRDPPEK
CCCCCCCCCCCCCCC		22.5930377154
595AcetylationSSRDPPEKSIPLCTL
CCCCCCCCCCCCEEE		60.5024489116
595UbiquitinationSSRDPPEKSIPLCTL
CCCCCCCCCCCCEEE		60.5023749301
596PhosphorylationSRDPPEKSIPLCTLR
CCCCCCCCCCCEEEE		27.9821440633
608UbiquitinationTLRSFPNKIDHTIAW
EEECCCCCHHHHHHH		50.1523749301
608AcetylationTLRSFPNKIDHTIAW
EEECCCCCHHHHHHH		50.1524489116
657PhosphorylationDVKGVLESISDSLSS
CHHHHHHHHHHHHHC		24.1921440633
665AcetylationISDSLSSKPHNFEDC
HHHHHHCCCCCHHHH		47.0924489116
665UbiquitinationISDSLSSKPHNFEDC
HHHHHHCCCCCHHHH		47.0923749301
674UbiquitinationHNFEDCIKWARLEFE
CCHHHHHHHHHHHHH		40.9223749301
674AcetylationHNFEDCIKWARLEFE
CCHHHHHHHHHHHHH		40.9224489116
689AcetylationKKFNHDIKQLLFNFP
HHHCCCHHHHHHCCC		40.7324489116
697AcetylationQLLFNFPKDAKTSNG
HHHHCCCCCCCCCCC		67.2024489116
712AcetylationEPFWSGAKRAPTPLE
CCCCCCCCCCCCCCE		53.2524489116
712UbiquitinationEPFWSGAKRAPTPLE
CCCCCCCCCCCCCCE		53.2523749301
712SuccinylationEPFWSGAKRAPTPLE
CCCCCCCCCCCCCCE		53.2523954790
745AcetylationRAYNYGIKSDDSNSK
HHHHCCCCCCCCCCC		43.3924489116
752UbiquitinationKSDDSNSKPNVDEYK
CCCCCCCCCCHHHHH		44.8823749301
759UbiquitinationKPNVDEYKSVIDHMI
CCCHHHHHHHHCCCC		35.8817644757
777UbiquitinationFTPNANLKIQVNDDD
CCCCCCCEEEECCCC		30.7917644757
8882-HydroxyisobutyrylationLYKLIDNKTDIEQYK
HHHHHCCCCCHHHHH		43.77-
888SuccinylationLYKLIDNKTDIEQYK
HHHHHCCCCCHHHHH		43.7723954790
888UbiquitinationLYKLIDNKTDIEQYK
HHHHHCCCCCHHHHH		43.7723749301
895UbiquitinationKTDIEQYKNGFVNLA
CCCHHHHHCCCCCEE		50.7317644757
909PhosphorylationALPFFGFSEPIASPK
ECCCCCCCCCCCCCC		42.7321440633
914PhosphorylationGFSEPIASPKGEYNN
CCCCCCCCCCCCCCC		28.0628889911
916UbiquitinationSEPIASPKGEYNNKK
CCCCCCCCCCCCCCC		62.9817644757
934AcetylationIWDRFDIKGDIKLSD
HHHHCCCCCCEEHHH		52.9924489116
938AcetylationFDIKGDIKLSDLIEH
CCCCCCEEHHHHHHH		46.8324489116
987AcetylationLPITQLVKLVTKKDI
CCHHHHHHHHHCCCC		45.9224489116
991AcetylationQLVKLVTKKDIPAHV
HHHHHHHCCCCCHHH		40.7524489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of UBA1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of UBA1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of UBA1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
GCH1_YEASTFOL2physical
11805837
SERC_YEASTSER1physical
11805837
STI1_YEASTSTI1physical
11805837
CYS3_YEASTCYS3physical
16554755
DPOA2_YEASTPOL12physical
16554755
HSP79_YEASTSSE2physical
16554755
YD415_YEASTYDR415Cphysical
16554755
C1TC_YEASTADE3physical
16554755
KSP1_YEASTKSP1physical
16554755
RAX2_YEASTRAX2physical
16554755
SERC_YEASTSER1physical
16554755
UBC1_YEASTUBC1physical
18662542
PRS7_YEASTRPT1physical
18757749
UBC3_YEASTCDC34physical
22949505
UBC1_YEASTUBC1physical
22072716
UBC4_YEASTUBC4physical
22072716
UBC4_YEASTUBC4physical
22085930
UBCX_YEASTPEX4physical
22085930
UBC6_YEASTUBC6physical
8396728
UBI4P_YEASTUBI4physical
2265617
UBC1_YEASTUBC1physical
2265617
UBI4P_YEASTUBI4physical
1989885
UBC2_YEASTRAD6physical
9287349
UBI4P_YEASTUBI4physical
18662542
UBA1_YEASTUBA1physical
8396728
VPS53_YEASTVPS53genetic
27708008
RL6B_YEASTRPL6Bgenetic
27708008
BRE5_YEASTBRE5genetic
27708008
APC11_YEASTAPC11genetic
27708008
FAD1_YEASTFAD1genetic
27708008
DPOD_YEASTPOL3genetic
27708008
NSE4_YEASTNSE4genetic
27708008
GLE1_YEASTGLE1genetic
27708008
SC61G_YEASTSSS1genetic
27708008
CDC1_YEASTCDC1genetic
27708008
SP110_YEASTSPC110genetic
27708008
SMT3_YEASTSMT3genetic
27708008
MOB2_YEASTMOB2genetic
27708008
PSB7_YEASTPRE4genetic
27708008
PRS8_YEASTRPT6genetic
27708008
CDC20_YEASTCDC20genetic
27708008
PRI1_YEASTPRI1genetic
27708008
TIM16_YEASTPAM16genetic
27708008
CDC6_YEASTCDC6genetic
27708008
YJ9I_YEASTYJR141Wgenetic
27708008
PRI2_YEASTPRI2genetic
27708008
RNA1_YEASTRNA1genetic
27708008
GPI12_YEASTGPI12genetic
27708008
NOP2_YEASTNOP2genetic
27708008
DPOA_YEASTPOL1genetic
27708008
TYSY_YEASTCDC21genetic
27708008
PROF_YEASTPFY1genetic
27708008
RPB2_YEASTRPB2genetic
27708008
APC5_YEASTAPC5genetic
27708008
SEC63_YEASTSEC63genetic
27708008
PSA7_YEASTPRE10genetic
27708008
TIM50_YEASTTIM50genetic
27708008
GPI2_YEASTGPI2genetic
27708008
MOT1_YEASTMOT1genetic
27708008
SEC62_YEASTSEC62genetic
27708008
NAB3_YEASTNAB3genetic
27708008
MDM10_YEASTMDM10genetic
27708008
GEM1_YEASTGEM1genetic
27708008
ICS2_YEASTICS2genetic
27708008
ARL1_YEASTARL1genetic
27708008
ATG12_YEASTATG12genetic
27708008
SWC5_YEASTSWC5genetic
27708008
RMD9L_YEASTYBR238Cgenetic
27708008
SLX5_YEASTSLX5genetic
27708008
PEX19_YEASTPEX19genetic
27708008
RLA1_YEASTRPP1Agenetic
27708008
RLA3_YEASTRPP1Bgenetic
27708008
VPS72_YEASTVPS72genetic
27708008
YD514_YEASTYDR514Cgenetic
27708008
CEM1_YEASTCEM1genetic
27708008
SWI4_YEASTSWI4genetic
27708008
ATG1_YEASTATG1genetic
27708008
NIF3_YEASTNIF3genetic
27708008
CUL3_YEASTCUL3genetic
27708008
CHO2_YEASTCHO2genetic
27708008
SNF6_YEASTSNF6genetic
27708008
CSK21_YEASTCKA1genetic
27708008
ACA2_YEASTCST6genetic
27708008
SWE1_YEASTSWE1genetic
27708008
RT109_YEASTRTT109genetic
27708008
METW_YEASTYLL058Wgenetic
27708008
PUR91_YEASTADE16genetic
27708008
RL22A_YEASTRPL22Agenetic
27708008
ARP6_YEASTARP6genetic
27708008
ELO3_YEASTELO3genetic
27708008
SEI1_YEASTFLD1genetic
27708008
RL36A_YEASTRPL36Agenetic
27708008
RS10B_YEASTRPS10Bgenetic
27708008
OCA2_YEASTOCA2genetic
27708008
SIN3_YEASTSIN3genetic
27708008
FYV12_YEASTFYV12genetic
27708008
DGK1_YEASTDGK1genetic
27708008
TRM44_YEASTTRM44genetic
27708008
NCBP2_YEASTCBC2genetic
27708008
CTF4_YEASTCTF4genetic
27708008
RS31_YEASTRPS31physical
28578874
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of UBA1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-187 AND SER-914, ANDMASS SPECTROMETRY.
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-265, AND MASSSPECTROMETRY.

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