| UniProt ID | UBC6_YEAST | |
|---|---|---|
| UniProt AC | P33296 | |
| Protein Name | Ubiquitin-conjugating enzyme E2 6 | |
| Gene Name | UBC6 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 250 | |
| Subcellular Localization | Endoplasmic reticulum membrane . | |
| Protein Description | Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in degradation of misfolded or regulated proteins localized in the endoplasmic reticulum (ER) lumen or membrane via the ubiquitin-proteasome system. Cognate E2 conjugating enzyme for the DOA10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains.. | |
| Protein Sequence | MATKQAHKRLTKEYKLMVENPPPYILARPNEDNILEWHYIITGPADTPYKGGQYHGTLTFPSDYPYKPPAIRMITPNGRFKPNTRLCLSMSDYHPDTWNPGWSVSTILNGLLSFMTSDEATTGSITTSDHQKKTLARNSISYNTFQNVRFKLIFPEVVQENVETLEKRKLDEGDAANTGDETEDPFTKAAKEKVISLEEILDPEDRIRAEQALRQSENNSKKDGKEPNDSSSMVYIGIAIFLFLVGLFMK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 50 | Ubiquitination | GPADTPYKGGQYHGT CCCCCCCCCCEEEEE | 58.74 | 17644757 | |
| 67 | Ubiquitination | FPSDYPYKPPAIRMI CCCCCCCCCCEEEEE | 39.77 | 23749301 | |
| 139 | Phosphorylation | KKTLARNSISYNTFQ HHHHHCCCCCCCCCC | 13.83 | 28889911 | |
| 151 | Ubiquitination | TFQNVRFKLIFPEVV CCCCEEEEECCHHHH | 30.06 | 23749301 | |
| 167 | Ubiquitination | ENVETLEKRKLDEGD HHHHHHHHHCCCCCC | 58.93 | 23749301 | |
| 169 | Ubiquitination | VETLEKRKLDEGDAA HHHHHHHCCCCCCCC | 71.94 | 23749301 | |
| 178 | Phosphorylation | DEGDAANTGDETEDP CCCCCCCCCCCCCCH | 41.08 | 25521595 | |
| 182 | Phosphorylation | AANTGDETEDPFTKA CCCCCCCCCCHHHHH | 50.88 | 25521595 | |
| 187 | Phosphorylation | DETEDPFTKAAKEKV CCCCCHHHHHHHHHC | 25.76 | 26447709 | |
| 188 | Ubiquitination | ETEDPFTKAAKEKVI CCCCHHHHHHHHHCC | 46.88 | 24961812 | |
| 193 | Ubiquitination | FTKAAKEKVISLEEI HHHHHHHHCCCHHHH | 44.13 | 24961812 | |
| 196 | Phosphorylation | AAKEKVISLEEILDP HHHHHCCCHHHHCCH | 32.49 | 19779198 |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of UBC6_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of UBC6_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-178, AND MASSSPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-178, AND MASSSPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-178, AND MASSSPECTROMETRY. | |
