| UniProt ID | PCL8_YEAST | |
|---|---|---|
| UniProt AC | Q08966 | |
| Protein Name | PHO85 cyclin-8 | |
| Gene Name | PCL8 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 492 | |
| Subcellular Localization | Cytoplasm. Nucleus. | |
| Protein Description | Cyclin partner of the cyclin-dependent kinase (CDK) PHO85. Together with cyclin PCL10, negatively controls glycogen accumulation under favorable growth conditions. Involved in phosphorylation and negative regulation of glycogen synthase GSY2. Also has minor GLC8 kinase activity.. | |
| Protein Sequence | MANDQDPNKSLINDALTRSMSEFYDDDDDNDSDMCRANDEGEDVFDLPLKVGVSQSRNFSEVNDVLDPLSSLHGPSKKVRFEQQKQQQQHQQLHNDFNTDFNLKSPSSKKMGVEQLIQSANEINDYLANNIDKVNSFNSELLSGSGKLPGRVKSDTATQGTGRLDSMSNFALSDTELDNDDDNYLLDPLANASSTTPTVEHHGYSLLDKALSTSDKEKIYTNKVNSNSQIDTDNHSHESGNTTNNETDENESSEILDYTKFDSFPYPPSSAPNGEPPDLKVLSIECEQENEKELRRISLLLDHYESIPKIPELSDDEALSKFRENIELILQLSKKINDNANTLAISSEDPQKFVNFVMKNPPSLSFRDFIDRIQNKCMFGAVVYLGATYLLQLVFLTRDEMDGPIKLKAKLQEDQAHRIIISTIRIATKLLEDFVHSQNYICKVFGISKRLLTKLEISFMASVNFDGLMITCEKLEKTLHILDDTRQALGNT | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 19 | Phosphorylation | INDALTRSMSEFYDD HHHHHHHHHHHHCCC | 22.79 | 30377154 | |
| 21 | Phosphorylation | DALTRSMSEFYDDDD HHHHHHHHHHCCCCC | 26.29 | 21440633 | |
| 32 | Phosphorylation | DDDDDNDSDMCRAND CCCCCCCCCCHHCCC | 33.23 | 21440633 | |
| 54 | Phosphorylation | LPLKVGVSQSRNFSE CCCEECCCCCCCHHH | 19.26 | 30377154 | |
| 56 | Phosphorylation | LKVGVSQSRNFSEVN CEECCCCCCCHHHHH | 22.99 | 30377154 | |
| 60 | Phosphorylation | VSQSRNFSEVNDVLD CCCCCCHHHHHHHHH | 44.15 | 28889911 | |
| 70 | Phosphorylation | NDVLDPLSSLHGPSK HHHHHHHHHCCCCCH | 35.92 | 19779198 | |
| 71 | Phosphorylation | DVLDPLSSLHGPSKK HHHHHHHHCCCCCHH | 31.87 | 30377154 | |
| 76 | Phosphorylation | LSSLHGPSKKVRFEQ HHHCCCCCHHHHHHH | 50.10 | 19779198 | |
| 105 | Phosphorylation | NTDFNLKSPSSKKMG CCCCCCCCCCHHHCC | 32.93 | 25704821 | |
| 126 | Phosphorylation | SANEINDYLANNIDK HHHHHHHHHHHCHHH | 11.83 | 21440633 | |
| 136 | Phosphorylation | NNIDKVNSFNSELLS HCHHHHHCCCHHHHC | 28.88 | 22369663 | |
| 139 | Phosphorylation | DKVNSFNSELLSGSG HHHHCCCHHHHCCCC | 27.84 | 20377248 | |
| 143 | Phosphorylation | SFNSELLSGSGKLPG CCCHHHHCCCCCCCC | 43.46 | 22369663 | |
| 145 | Phosphorylation | NSELLSGSGKLPGRV CHHHHCCCCCCCCCC | 29.40 | 22369663 | |
| 154 | Phosphorylation | KLPGRVKSDTATQGT CCCCCCCCCCCCCCC | 37.02 | 25752575 | |
| 156 | Phosphorylation | PGRVKSDTATQGTGR CCCCCCCCCCCCCCC | 38.40 | 30377154 | |
| 270 | Phosphorylation | SFPYPPSSAPNGEPP CCCCCCCCCCCCCCC | 54.22 | 28889911 | |
| 283 | Phosphorylation | PPDLKVLSIECEQEN CCCCEEEEEEECCCC | 21.23 | 25704821 | |
| 321 | Ubiquitination | SDDEALSKFRENIEL CCHHHHHHHHHHHHH | 49.65 | 23749301 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PCL8_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PCL8_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PCL8_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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