| UniProt ID | CRD1_YEAST | |
|---|---|---|
| UniProt AC | Q07560 | |
| Protein Name | Cardiolipin synthase (CMP-forming) | |
| Gene Name | CRD1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 283 | |
| Subcellular Localization |
Mitochondrion inner membrane Multi-pass membrane protein. |
|
| Protein Description | Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol (PG). CL is a key phospholipid in mitochondrial membranes and plays important roles in maintaining the functional integrity and dynamics of mitochondria under both optimal and stress conditions.. | |
| Protein Sequence | MIQMVPIYSCSALLRRTIPKRPFYHVLSGLTVRFKVNPQLNYNLFRDLTRREYATNPSKTPHIKSKLLNIPNILTLSRIGCTPFIGLFIITNNLTPALGLFAFSSITDFMDGYIARKYGLKTIAGTILDPLADKLLMITTTLALSVPSGPQIIPVSIAAIILGRDVLLAISALFIRYSTLKLKYPGRVAWNSYWDIVRYPSAEVRPSQLSKWNTFFQMVYLGSGVLLLLYEKEEGCEKTEEDFEDRKQDFQKAFSYLGYVTATTTIMSGVSYALKRNAFKLLK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 8 | Phosphorylation | MIQMVPIYSCSALLR CCCCEEEECHHHHHH | 9.50 | 30377154 | |
| 24 | Phosphorylation | TIPKRPFYHVLSGLT CCCCCCCEEECCCCE | 8.16 | 27017623 | |
| 31 | Phosphorylation | YHVLSGLTVRFKVNP EEECCCCEEEEECCC | 17.11 | 27017623 | |
| 126 | Phosphorylation | GLKTIAGTILDPLAD CCCCCCCHHHHHHHH | 14.89 | 28889911 | |
| 255 | Phosphorylation | QDFQKAFSYLGYVTA HHHHHHHHHHHHHHH | 25.06 | 30377154 | |
| 256 | Phosphorylation | DFQKAFSYLGYVTAT HHHHHHHHHHHHHHH | 9.55 | 30377154 | |
| 259 | Phosphorylation | KAFSYLGYVTATTTI HHHHHHHHHHHHHHH | 7.64 | 30377154 | |
| 261 | Phosphorylation | FSYLGYVTATTTIMS HHHHHHHHHHHHHHH | 15.14 | 30377154 | |
| 263 | Phosphorylation | YLGYVTATTTIMSGV HHHHHHHHHHHHHHH | 18.33 | 30377154 | |
| 264 | Phosphorylation | LGYVTATTTIMSGVS HHHHHHHHHHHHHHH | 16.32 | 30377154 | |
| 265 | Phosphorylation | GYVTATTTIMSGVSY HHHHHHHHHHHHHHH | 15.44 | 30377154 | |
| 268 | Phosphorylation | TATTTIMSGVSYALK HHHHHHHHHHHHHHH | 31.99 | 30377154 | |
| 271 | Phosphorylation | TTIMSGVSYALKRNA HHHHHHHHHHHHHCH | 14.28 | 30377154 | |
| 272 | Phosphorylation | TIMSGVSYALKRNAF HHHHHHHHHHHHCHH | 17.34 | 30377154 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CRD1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CRD1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CRD1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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