dbPTM

PXL1_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PXL1_YEAST
UniProt AC	P36166
Protein Name	Paxillin-like protein 1
Gene Name	PXL1
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	706
Subcellular Localization
Protein Description
Protein Sequence	MYNSIYGSPFPKINPKVRYKTALERAGFDTKPRNPFSSQRNASTGSLQASVKSPPITRQRNVSAAPSVPVTMKSAYTASSKSAYSSVKGESDIYPPPVLENSERRSVTPPKNSNFTSSRPSDISRSISRPSERASQEDPFRFERDLDRQAEQYAASRHTCKSPANKEFQAADNFPFNFEQEDAGNTEREQDLSPIERSFMMLTQNDTASVVNSMNQTDNRGVLDQKLGKEQQKEESSIEYESEGQQEDENDIESLNFEPDPKLQMNLENEPLQDDFPEAKQEEKNTEPKIPEINVTRESNTPSLTMNALDSKIYPDDNFSGLESSKEQKSPGVSSSSTKVEDLSLDGLNEKRLSITSSENVETPYTATNLQVEQLIAQLDDVSLSRNAKLDMNGNCLNAVDRKASRFKKSSAYLSGYPSMDIPVTQQTSIVQNSNTNLSRQTILVDKGDVDEDAPSESTTNGGTPIFYKFKQSNVEYSNNEGMGSQETFRTKLPTIEALQLQHKRNITDLREEIDNSKSNDSHVLPNGGTTRYSSDADYKETEPIEFKYPPGEGPCRACGLEVTGKRMFSKKENELSGQWHRECFKCIECGIKFNKHVPCYILGDEPYCQKHYHEENHSICKVCSNFIEGECLENDKVERFHVDCLNCFLCKTAITNDYYIFNGEIPLCGNHDMEALLKEGIDNATSSNDKNNTLSKRRTRLINFN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MYNSIYGSPFPKINP CCCCCCCCCCCCCCH	13.34	28152593
21	Phosphorylation	NPKVRYKTALERAGF CHHHCHHHHHHHCCC	27.78	21440633
37	Phosphorylation	TKPRNPFSSQRNAST CCCCCCCCCCCCCCC	27.15	19823750
38	Phosphorylation	KPRNPFSSQRNASTG CCCCCCCCCCCCCCC	33.27	21440633
43	Phosphorylation	FSSQRNASTGSLQAS CCCCCCCCCCCCEEE	36.53	22369663
44	Phosphorylation	SSQRNASTGSLQASV CCCCCCCCCCCEEEC	28.51	22369663
46	Phosphorylation	QRNASTGSLQASVKS CCCCCCCCCEEECCC	19.87	22369663
50	Phosphorylation	STGSLQASVKSPPIT CCCCCEEECCCCCCC	19.67	22369663
53	Phosphorylation	SLQASVKSPPITRQR CCEEECCCCCCCCCC	33.48	22369663
57	Phosphorylation	SVKSPPITRQRNVSA ECCCCCCCCCCCCCC	26.90	22369663
63	Phosphorylation	ITRQRNVSAAPSVPV CCCCCCCCCCCCCCE	23.43	22369663
67	Phosphorylation	RNVSAAPSVPVTMKS CCCCCCCCCCEEECE	34.03	19684113
71	Phosphorylation	AAPSVPVTMKSAYTA CCCCCCEEECEEEEC	16.89	24961812
74	Phosphorylation	SVPVTMKSAYTASSK CCCEEECEEEECCCC	18.71	30377154
76	Phosphorylation	PVTMKSAYTASSKSA CEEECEEEECCCCHH	15.21	30377154
77	Phosphorylation	VTMKSAYTASSKSAY EEECEEEECCCCHHH	21.56	30377154
79	Phosphorylation	MKSAYTASSKSAYSS ECEEEECCCCHHHHC	30.42	30377154
82	Phosphorylation	AYTASSKSAYSSVKG EEECCCCHHHHCCCC	34.09	28889911
85	Phosphorylation	ASSKSAYSSVKGESD CCCCHHHHCCCCCCC	28.50	19779198
91	Phosphorylation	YSSVKGESDIYPPPV HHCCCCCCCCCCCCC	37.67	22369663
94	Phosphorylation	VKGESDIYPPPVLEN CCCCCCCCCCCCCCC	18.06	22369663
102	Phosphorylation	PPPVLENSERRSVTP CCCCCCCCCCCCCCC	24.09	22369663
106	Phosphorylation	LENSERRSVTPPKNS CCCCCCCCCCCCCCC	36.24	22369663
108	Phosphorylation	NSERRSVTPPKNSNF CCCCCCCCCCCCCCC	34.81	22369663
113	Phosphorylation	SVTPPKNSNFTSSRP CCCCCCCCCCCCCCC	39.17	30377154
118	Phosphorylation	KNSNFTSSRPSDISR CCCCCCCCCCHHHHH	45.19	28889911
124	Phosphorylation	SSRPSDISRSISRPS CCCCHHHHHHCCCCC	25.60	28889911
126	Phosphorylation	RPSDISRSISRPSER CCHHHHHHCCCCCHH	20.37	25704821
128	Phosphorylation	SDISRSISRPSERAS HHHHHHCCCCCHHHC	39.11	29650682
135	Phosphorylation	SRPSERASQEDPFRF CCCCHHHCCCCCCCC	40.08	23749301
156	Phosphorylation	QAEQYAASRHTCKSP HHHHHHHHHCCCCCC	19.20	28889911
193	Phosphorylation	TEREQDLSPIERSFM CHHHCCCCHHHHHHE	31.92	24930733
198	Phosphorylation	DLSPIERSFMMLTQN CCCHHHHHHEEHHCC	12.52	27017623
203	Phosphorylation	ERSFMMLTQNDTASV HHHHEEHHCCCHHHH	13.87	27017623
209	Phosphorylation	LTQNDTASVVNSMNQ HHCCCHHHHHHCCCC	28.79	28889911
217	Phosphorylation	VVNSMNQTDNRGVLD HHHCCCCCCCCCHHH	30.18	28889911
237	Phosphorylation	EQQKEESSIEYESEG HHHHHHHCCCCCCCC	23.79	21551504
240	Phosphorylation	KEESSIEYESEGQQE HHHHCCCCCCCCCCC	24.08	19779198
242	Phosphorylation	ESSIEYESEGQQEDE HHCCCCCCCCCCCCC	46.23	19779198
254	Phosphorylation	EDENDIESLNFEPDP CCCCCHHHCCCCCCH	29.01	21551504
296	Phosphorylation	KIPEINVTRESNTPS CCCCCCEECCCCCCC	25.00	20377248
299	Phosphorylation	EINVTRESNTPSLTM CCCEECCCCCCCEEE	42.59	22369663
301	Phosphorylation	NVTRESNTPSLTMNA CEECCCCCCCEEEHH	24.43	20377248
303	Phosphorylation	TRESNTPSLTMNALD ECCCCCCCEEEHHHC	34.14	22369663
305	Phosphorylation	ESNTPSLTMNALDSK CCCCCCEEEHHHCCC	16.83	22369663
311	Phosphorylation	LTMNALDSKIYPDDN EEEHHHCCCCCCCCC	23.08	22369663
320	Phosphorylation	IYPDDNFSGLESSKE CCCCCCCCCCCCCCC	49.04	28152593
324	Phosphorylation	DNFSGLESSKEQKSP CCCCCCCCCCCCCCC	52.32	24961812
325	Phosphorylation	NFSGLESSKEQKSPG CCCCCCCCCCCCCCC	30.73	24961812
326	Ubiquitination	FSGLESSKEQKSPGV CCCCCCCCCCCCCCC	73.73	24961812
330	Phosphorylation	ESSKEQKSPGVSSSS CCCCCCCCCCCCCCC	26.95	22369663
334	Phosphorylation	EQKSPGVSSSSTKVE CCCCCCCCCCCCCEE	30.34	22369663
335	Phosphorylation	QKSPGVSSSSTKVED CCCCCCCCCCCCEEE	26.38	22369663
336	Phosphorylation	KSPGVSSSSTKVEDL CCCCCCCCCCCEEEC	34.22	22369663
337	Phosphorylation	SPGVSSSSTKVEDLS CCCCCCCCCCEEECC	33.91	23749301
338	Phosphorylation	PGVSSSSTKVEDLSL CCCCCCCCCEEECCC	40.85	22369663
344	Phosphorylation	STKVEDLSLDGLNEK CCCEEECCCCCCCCC	36.41	25704821
354	Phosphorylation	GLNEKRLSITSSENV CCCCCCEECCCCCCC	28.05	21440633
356	Phosphorylation	NEKRLSITSSENVET CCCCEECCCCCCCCC	23.87	19779198
357	Phosphorylation	EKRLSITSSENVETP CCCEECCCCCCCCCC	33.70	19779198
358	Phosphorylation	KRLSITSSENVETPY CCEECCCCCCCCCCC	25.25	19779198
410	Phosphorylation	KASRFKKSSAYLSGY HHHHHHHHHHHHCCC	22.31	28889911
411	Phosphorylation	ASRFKKSSAYLSGYP HHHHHHHHHHHCCCC	29.79	28889911
413	Phosphorylation	RFKKSSAYLSGYPSM HHHHHHHHHCCCCCC	11.89	28889911
415	Phosphorylation	KKSSAYLSGYPSMDI HHHHHHHCCCCCCCC	24.49	28889911
417	Phosphorylation	SSAYLSGYPSMDIPV HHHHHCCCCCCCCCC	6.69	28889911
419	Phosphorylation	AYLSGYPSMDIPVTQ HHHCCCCCCCCCCCC	22.17	28889911
442	Phosphorylation	NTNLSRQTILVDKGD CCCCEECEEEEECCC	18.37	22369663
456	Phosphorylation	DVDEDAPSESTTNGG CCCCCCCCCCCCCCC	45.99	22369663
458	Phosphorylation	DEDAPSESTTNGGTP CCCCCCCCCCCCCCE	44.89	22369663
459	Phosphorylation	EDAPSESTTNGGTPI CCCCCCCCCCCCCEE	21.89	22369663
460	Phosphorylation	DAPSESTTNGGTPIF CCCCCCCCCCCCEEE	40.94	22369663
464	Phosphorylation	ESTTNGGTPIFYKFK CCCCCCCCEEEEEEE	18.01	22369663
468	Phosphorylation	NGGTPIFYKFKQSNV CCCCEEEEEEEHHCC	19.08	22369663
473	Phosphorylation	IFYKFKQSNVEYSNN EEEEEEHHCCEECCC	43.35	22369663
477	Phosphorylation	FKQSNVEYSNNEGMG EEHHCCEECCCCCCC	16.65	22369663
478	Phosphorylation	KQSNVEYSNNEGMGS EHHCCEECCCCCCCC	21.48	22369663
485	Phosphorylation	SNNEGMGSQETFRTK CCCCCCCCHHHHHHH	18.89	22369663
488	Phosphorylation	EGMGSQETFRTKLPT CCCCCHHHHHHHCCH	15.69	24909858
491	Phosphorylation	GSQETFRTKLPTIEA CCHHHHHHHCCHHHH	32.51	22369663
508	Phosphorylation	LQHKRNITDLREEID HHHHCCCHHHHHHHH	32.31	24961812
519	Phosphorylation	EEIDNSKSNDSHVLP HHHHCCCCCCCCCCC	45.77	19823750
522	Phosphorylation	DNSKSNDSHVLPNGG HCCCCCCCCCCCCCC	21.53	19823750
530	Phosphorylation	HVLPNGGTTRYSSDA CCCCCCCCCEECCCC	14.97	21440633
531	Phosphorylation	VLPNGGTTRYSSDAD CCCCCCCCEECCCCC	30.77	19823750
533	Phosphorylation	PNGGTTRYSSDADYK CCCCCCEECCCCCCC	15.50	21440633
534	Phosphorylation	NGGTTRYSSDADYKE CCCCCEECCCCCCCC	20.60	19823750
535	Phosphorylation	GGTTRYSSDADYKET CCCCEECCCCCCCCC	28.08	21440633
539	Phosphorylation	RYSSDADYKETEPIE EECCCCCCCCCCCCC	16.67	19823750
625	Phosphorylation	HSICKVCSNFIEGEC CCHHHHCCHHHCCHH	37.45	23749301

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PXL1_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PXL1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PXL1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
RHO1_YEAST	RHO1	physical	15215315

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PXL1_YEAST

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-63 AND SER-299, AND MASSSPECTROMETRY.	18407956 [Abstract]
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-193, AND MASSSPECTROMETRY.	17563356 [Abstract]