MSG5_YEAST - dbPTM
MSG5_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MSG5_YEAST
UniProt AC P38590
Protein Name Tyrosine-protein phosphatase MSG5
Gene Name MSG5
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 489
Subcellular Localization
Protein Description Dual specificity phosphatase that dephosphorylates MAP kinase FUS3 on both a Tyr and a Ser or Thr. Has a role in adaptation to pheromone..
Protein Sequence MQFHSDKQHLDSKTDIDFKPNSPRSLQNRNTKNLSLDIAALHPLMEFSSPSQDVPGSVKFPSPTPLNLFMKPKPIVLEKCPPKVSPRPTPPSLSMRRSEASIYTLPTSLKNRTVSPSVYTKSSTVSSISKLSSSSPLSSFSEKPHLNRVHSLSVKTKDLKLKGIRGRSQTISGLETSTPISSTREGTLDSTDVNRFSNQKNMQTTLIFPEEDSDLNIDMVHAEIYQRTVYLDGPLLVLPPNLYLYSEPKLEDILSFDLVINVAKEIPNLEFLIPPEMAHKIKYYHIEWTHTSKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIVAYIMRYYGLSLNDAYNKLKGVAKDISPNMGLIFQLMEWGTMLSKNSPGEEGETVHMPEEDDIGNNEVSSTTKSYSSASFRSFPMVTNLSSSPNDSSVNSSEVTPRTPATLTGARTALATERGEDDEHCKSLSQPADSLEASVDNESISTAPEQMMFLP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
22PhosphorylationDIDFKPNSPRSLQNR
CCCCCCCCCHHHHCC		30.1617330950
62PhosphorylationPGSVKFPSPTPLNLF
CCCCCCCCCCCCCEE		44.5329734811
85PhosphorylationEKCPPKVSPRPTPPS
ECCCCCCCCCCCCCC		22.7121440633
92PhosphorylationSPRPTPPSLSMRRSE
CCCCCCCCCCCCCCC		33.9921440633
94PhosphorylationRPTPPSLSMRRSEAS
CCCCCCCCCCCCCCE		18.0021440633
98PhosphorylationPSLSMRRSEASIYTL
CCCCCCCCCCEEEEC		27.4422369663
101PhosphorylationSMRRSEASIYTLPTS
CCCCCCCEEEECCCC		16.4519779198
103PhosphorylationRRSEASIYTLPTSLK
CCCCCEEEECCCCCC		10.3422369663
104PhosphorylationRSEASIYTLPTSLKN
CCCCEEEECCCCCCC		25.2922369663
107PhosphorylationASIYTLPTSLKNRTV
CEEEECCCCCCCCCC		50.2122369663
108PhosphorylationSIYTLPTSLKNRTVS
EEEECCCCCCCCCCC		35.0922369663
115PhosphorylationSLKNRTVSPSVYTKS
CCCCCCCCCCCEECC		15.7321440633
132PhosphorylationVSSISKLSSSSPLSS
HHHHHHHCCCCCCHH		31.7329688323
133PhosphorylationSSISKLSSSSPLSSF
HHHHHHCCCCCCHHC		45.3219684113
134PhosphorylationSISKLSSSSPLSSFS
HHHHHCCCCCCHHCC		32.3820377248
135PhosphorylationISKLSSSSPLSSFSE
HHHHCCCCCCHHCCC		31.6317330950
141PhosphorylationSSPLSSFSEKPHLNR
CCCCHHCCCCCCCCC		46.8121440633
151PhosphorylationPHLNRVHSLSVKTKD
CCCCCCEEEEEECCC		21.3417330950
153PhosphorylationLNRVHSLSVKTKDLK
CCCCEEEEEECCCCE		25.2824961812
168PhosphorylationLKGIRGRSQTISGLE
ECCCCCCCCEECCCC		34.2021440633
170PhosphorylationGIRGRSQTISGLETS
CCCCCCCEECCCCCC		20.5428152593
172PhosphorylationRGRSQTISGLETSTP
CCCCCEECCCCCCCC		40.4924961812
176PhosphorylationQTISGLETSTPISST
CEECCCCCCCCCCCC		42.8323749301
177PhosphorylationTISGLETSTPISSTR
EECCCCCCCCCCCCC		23.8628152593
178PhosphorylationISGLETSTPISSTRE
ECCCCCCCCCCCCCC		31.8717330950
181PhosphorylationLETSTPISSTREGTL
CCCCCCCCCCCCCCC		27.1917330950
182PhosphorylationETSTPISSTREGTLD
CCCCCCCCCCCCCCC		32.0023749301
183PhosphorylationTSTPISSTREGTLDS
CCCCCCCCCCCCCCC		26.4224961812
187PhosphorylationISSTREGTLDSTDVN
CCCCCCCCCCCCCHH		23.7324961812
190PhosphorylationTREGTLDSTDVNRFS
CCCCCCCCCCHHHHC		29.6224961812
191PhosphorylationREGTLDSTDVNRFSN
CCCCCCCCCHHHHCC		43.5724961812
197PhosphorylationSTDVNRFSNQKNMQT
CCCHHHHCCCCCCCE		34.8024961812
400PhosphorylationIGNNEVSSTTKSYSS
CCCCCCCCCCCCCCC		45.3221551504
401PhosphorylationGNNEVSSTTKSYSSA
CCCCCCCCCCCCCCC		30.6421440633
412PhosphorylationYSSASFRSFPMVTNL
CCCCCCCCCCEEEEC		31.5219779198
417PhosphorylationFRSFPMVTNLSSSPN
CCCCCEEEECCCCCC		24.9623749301
420PhosphorylationFPMVTNLSSSPNDSS
CCEEEECCCCCCCCC		30.7327017623
421PhosphorylationPMVTNLSSSPNDSSV
CEEEECCCCCCCCCC		53.6427017623
422PhosphorylationMVTNLSSSPNDSSVN
EEEECCCCCCCCCCC		25.0921440633
426PhosphorylationLSSSPNDSSVNSSEV
CCCCCCCCCCCCCCC		42.7127017623
427PhosphorylationSSSPNDSSVNSSEVT
CCCCCCCCCCCCCCC		28.3427017623
430PhosphorylationPNDSSVNSSEVTPRT
CCCCCCCCCCCCCCC		26.2227017623
437PhosphorylationSSEVTPRTPATLTGA
CCCCCCCCCHHHHCH		20.6221440633
440PhosphorylationVTPRTPATLTGARTA
CCCCCCHHHHCHHHH		26.5129688323
442PhosphorylationPRTPATLTGARTALA
CCCCHHHHCHHHHHH		25.1729688323
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MSG5_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MSG5_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MSG5_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TAL1_YEASTTAL1physical
11805837
SLT2_YEASTSLT2physical
11805837
FUS3_YEASTFUS3physical
11805837
SLT2_YEASTSLT2physical
14703512
SLT2_YEASTSLT2physical
11923319
SLT2_YEASTSLT2physical
10625705
FUS3_YEASTFUS3physical
8306972
PP2C2_YEASTPTC2genetic
11967829
FUS3_YEASTFUS3physical
16364919
KSS1_YEASTKSS1physical
16364919
STE20_YEASTSTE20genetic
19269370
CTK3_YEASTCTK3genetic
19269370
CDC31_YEASTCDC31physical
20489023
CALM_YEASTCMD1physical
20489023
IVY1_YEASTIVY1physical
20489023
SP110_YEASTSPC110physical
20489023
SPC42_YEASTSPC42physical
20489023
STE50_YEASTSTE50genetic
20932477
KSS1_YEASTKSS1physical
21118957
KDX1_YEASTKDX1physical
21118957
SLT2_YEASTSLT2physical
21118957
SLT2_YEASTSLT2genetic
21127252
ASF1_YEASTASF1genetic
21127252
PP2C1_YEASTPTC1genetic
21127252
CG11_YEASTCLN1genetic
21127252
HAL4_YEASTSAT4genetic
21127252
BCK1_YEASTBCK1genetic
21127252
MOT3_YEASTMOT3genetic
21127252
NU133_YEASTNUP133genetic
21127252
FUS3_YEASTFUS3physical
22006927
KSS1_YEASTKSS1physical
22006927
SLT2_YEASTSLT2physical
22006927
KDX1_YEASTKDX1physical
22006927
POG1_YEASTPOG1genetic
9927449
CANB_YEASTCNB1genetic
23063697
SLT2_YEASTSLT2genetic
23063697
KPC1_YEASTPKC1genetic
27708008
STE50_YEASTSTE50genetic
27708008
CDS1_YEASTCDS1genetic
27708008
PRP6_YEASTPRP6genetic
27708008
CDK1_YEASTCDC28genetic
27708008
MED8_YEASTMED8genetic
27708008
MED22_YEASTSRB6genetic
27708008
FAD1_YEASTFAD1genetic
27708008
GLE1_YEASTGLE1genetic
27708008
YRB1_YEASTYRB1genetic
27708008
SLU7_YEASTSLU7genetic
27708008
TAF12_YEASTTAF12genetic
27708008
NSE3_YEASTNSE3genetic
27708008
CCA1_YEASTCCA1genetic
27708008
CDC4_YEASTCDC4genetic
27708008
CAK1_YEASTCAK1genetic
27708008
STT3_YEASTSTT3genetic
27708008
MCE1_YEASTCEG1genetic
27708008
PTI1_YEASTPTI1genetic
27708008
ZPR1_YEASTZPR1genetic
27708008
MED6_YEASTMED6genetic
27708008
SEC22_YEASTSEC22genetic
27708008
CDC91_YEASTGAB1genetic
27708008
ORC1_YEASTORC1genetic
27708008
POB3_YEASTPOB3genetic
27708008
RNA1_YEASTRNA1genetic
27708008
GPI12_YEASTGPI12genetic
27708008
MED7_YEASTMED7genetic
27708008
XRN2_YEASTRAT1genetic
27708008
SMP3_YEASTSMP3genetic
27708008
MED4_YEASTMED4genetic
27708008
RPAB3_YEASTRPB8genetic
27708008
CET1_YEASTCET1genetic
27708008
PSB5_YEASTPRE2genetic
27708008
IWS1_YEASTSPN1genetic
27708008
BUR1_YEASTSGV1genetic
27708008
SEC23_YEASTSEC23genetic
27708008
SNT1_YEASTSNT1genetic
27708008
SLX5_YEASTSLX5genetic
27708008
XRS2_YEASTXRS2genetic
27708008
RV167_YEASTRVS167genetic
27708008
SAC7_YEASTSAC7genetic
27708008
YBP2_YEASTYBP2genetic
27708008
VAM7_YEASTVAM7genetic
27708008
YGY0_YEASTYGL230Cgenetic
27708008
PSA3_YEASTPRE9genetic
27708008
DAL81_YEASTDAL81genetic
27708008
VPS53_YEASTVPS53genetic
27708008
VPS24_YEASTVPS24genetic
27708008
SAC1_YEASTSAC1genetic
27708008
ACE2_YEASTACE2genetic
27708008
UBX2_YEASTUBX2genetic
27708008
COG8_YEASTCOG8genetic
27708008
SUB1_YEASTSUB1genetic
27708008
MOT3_YEASTMOT3genetic
27708008
TOP1_YEASTTOP1genetic
27708008
SIL1_YEASTSIL1genetic
27708008
GYP1_YEASTGYP1genetic
27708008
YOR31_YEASTYOR131Cgenetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MSG5_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-151; SER-422 ANDTHR-437, AND MASS SPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22; SER-151 AND THR-178,AND MASS SPECTROMETRY.

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