SIL1_YEAST - dbPTM
SIL1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SIL1_YEAST
UniProt AC Q08199
Protein Name Nucleotide exchange factor SIL1
Gene Name SIL1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 421
Subcellular Localization Endoplasmic reticulum lumen.
Protein Description Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone KAR2..
Protein Sequence MVRILPIILSALSSKLVASTILHSSIHSVPSGGEIISAEDLKELEISGNSICVDNRCYPKIFEPRHDWQPILPGQELPGGLDIRINMDTGLKEAKLNDEKNVGDNGSHELIVSSEDMKASPGDYEFSSDFKEMRNIIDSNPTLSSQDIARLEDSFDRIMEFAHDYKHGYKIITHEFALLANLSLNENLPLTLRELSTRVITSCLRNNPPVVEFINESFPNFKSKIMAALSNLNDSNHRSSNILIKRYLSILNELPVTSEDLPIYSTVVLQNVYERNNKDKQLQIKVLELISKILKADMYENDDTNLILFKRNAENWSSNLQEWANEFQEMVQNKSIDELHTRTFFDTLYNLKKIFKSDITINKGFLNWLAQQCKARQSNLDNGLQERDTEQDSFDKKLIDSRHLIFGNPMAHRIKNFRDEL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
100AcetylationEAKLNDEKNVGDNGS
EECCCCCCCCCCCCC		60.8524489116
105N-linked_GlycosylationDEKNVGDNGSHELIV
CCCCCCCCCCEEEEE		48.19-
107PhosphorylationKNVGDNGSHELIVSS
CCCCCCCCEEEEEEH		21.7522369663
113PhosphorylationGSHELIVSSEDMKAS
CCEEEEEEHHHHCCC		22.4822369663
114PhosphorylationSHELIVSSEDMKASP
CEEEEEEHHHHCCCC		27.0722369663
120PhosphorylationSSEDMKASPGDYEFS
EHHHHCCCCCCCCCC		24.7322369663
131AcetylationYEFSSDFKEMRNIID
CCCCHHHHHHHHHHH		56.4424489116
166AcetylationMEFAHDYKHGYKIIT
HHHHHHHHCCCEEEH		36.2924489116
181N-linked_GlycosylationHEFALLANLSLNENL
HHHHHHHCCCCCCCC		30.08-
215N-linked_GlycosylationPPVVEFINESFPNFK
CCCHHHHHHCCCCHH		44.15-
233N-linked_GlycosylationMAALSNLNDSNHRSS
HHHHHCCCCCCCHHH		55.72-
315N-linked_GlycosylationLFKRNAENWSSNLQE
EEECCCCCCCHHHHH		41.33-
333N-linked_GlycosylationEFQEMVQNKSIDELH
HHHHHHHCCCHHHHH		28.73-
352AcetylationFDTLYNLKKIFKSDI
HHHHHHHHHHHHCCC		39.9424489116
356AcetylationYNLKKIFKSDITINK
HHHHHHHHCCCEECH		51.1724489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SIL1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SIL1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SIL1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
GRP78_YEASTKAR2physical
14704430
GRP78_YEASTKAR2physical
12052876
HSP71_YEASTSSA1physical
12052876
GRP78_YEASTKAR2physical
11101517
GRP78_YEASTKAR2physical
10958688
LHS1_YEASTLHS1genetic
11101517
GRP78_YEASTKAR2genetic
10958688
SEC63_YEASTSEC63genetic
10958688
LHS1_YEASTLHS1genetic
16269340
SEC62_YEASTSEC62genetic
16269340
HAC1_YEASTHAC1genetic
16269340
SEC63_YEASTSEC63genetic
16269340
INP54_YEASTINP54genetic
16269340
COPE_YEASTSEC28genetic
16269340
ERP4_YEASTERP4genetic
16269340
ERP5_YEASTERP5genetic
16269340
PMT2_YEASTPMT2genetic
16269340
EMC2_YEASTEMC2genetic
16269340
DYL1_YEASTDYN2genetic
16269340
TED1_YEASTTED1genetic
16269340
BRE5_YEASTBRE5genetic
19325107
CYS3_YEASTCYS3genetic
19325107
GCR2_YEASTGCR2genetic
19325107
GLO3_YEASTGLO3genetic
19325107
PHO80_YEASTPHO80genetic
19325107
SPT4_YEASTSPT4genetic
19325107
VPS1_YEASTVPS1genetic
19325107
ARP6_YEASTARP6genetic
19325107
GGPPS_YEASTBTS1genetic
19325107
ERJ5_YEASTERJ5genetic
19325107
ERP1_YEASTERP1genetic
19325107
GET1_YEASTGET1genetic
19325107
GET3_YEASTGET3genetic
19325107
H2AZ_YEASTHTZ1genetic
19325107
ISW1_YEASTISW1genetic
19325107
MPD1_YEASTMPD1genetic
19325107
RER1_YEASTRER1genetic
19325107
SUM1_YEASTSUM1genetic
19325107
SWC5_YEASTSWC5genetic
19325107
VPS71_YEASTVPS71genetic
19325107
VPS72_YEASTVPS72genetic
19325107
TAPT1_YEASTEMP65genetic
19325107
YHN8_YEASTYHR078Wgenetic
19325107
GRP78_YEASTKAR2physical
21675960
CHS3_YEASTCHS3genetic
27708008
AIM4_YEASTAIM4genetic
27708008
SLX1_YEASTSLX1genetic
27708008
TPS2_YEASTTPS2genetic
27708008
SWF1_YEASTSWF1genetic
27708008
SAC3_YEASTSAC3genetic
27708008
UME6_YEASTUME6genetic
27708008
PMP3_YEASTPMP3genetic
27708008
UBP3_YEASTUBP3genetic
27708008
RS27B_YEASTRPS27Bgenetic
27708008
MED20_YEASTSRB2genetic
27708008
IRE1_YEASTIRE1genetic
27708008
VPS53_YEASTVPS53genetic
27708008
SA185_YEASTSAP185genetic
27708008
IXR1_YEASTIXR1genetic
27708008
LHS1_YEASTLHS1genetic
27708008
ERG3_YEASTERG3genetic
27708008
RL22A_YEASTRPL22Agenetic
27708008
SST2_YEASTSST2genetic
27708008
MSC1_YEASTMSC1genetic
27708008
PKR1_YEASTPKR1genetic
27708008
MKS1_YEASTMKS1genetic
27708008
RS10A_YEASTRPS10Agenetic
27708008
PDE2_YEASTPDE2genetic
27708008
BEM3_YEASTBEM3genetic
27708008
PPQ1_YEASTPPQ1genetic
27708008
THRC_YEASTTHR4genetic
29674565
NHP10_YEASTNHP10genetic
29674565
APC11_YEASTAPC11genetic
29674565
HAC1_YEASTHAC1genetic
29674565
HTD2_YEASTHTD2genetic
29674565
RPC10_YEASTRPC11genetic
29674565
ERG5_YEASTERG5genetic
29674565
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SIL1_YEAST

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Related Literatures of Post-Translational Modification

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