INP54_YEAST - dbPTM
INP54_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID INP54_YEAST
UniProt AC Q08227
Protein Name Phosphatidylinositol 4,5-bisphosphate 5-phosphatase INP54
Gene Name INP54
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 384
Subcellular Localization Endoplasmic reticulum membrane
Peripheral membrane protein
Cytoplasmic side .
Protein Description Regulates the phosphatidylinositol (4,5)-diphosphate levels on the cytoplasmic surface of the endoplasmic reticulum and thereby regulates secretion. Does not utilize phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2), nor phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 4-phosphate (PtdIns(4)P)..
Protein Sequence MNKTNWKVSVTTFNCGKEFPVENSKAIVKQLLFPYDDGISQLELQDLYVLGFQEVVPIWQGSFPAVNRDLIDRITTTAVNCLNEKVSATQGDEQYSCLGVNSLGAITIIVLYNNNALKVKDDILKRNGKCGWFGTHLKGGTLISFQMTRNGEENWERFSYICAHLNANEGVNNRNQRIDDYKRIMSEVCDSEVAKSDHFFFLGDLNFRVTSTYDPTTNYSSTTTLRRLLENHEELNLLRKGEDEPLCKGFQELKITFPPTYKFKLFEKETYNTKRIPSWCDRILYKSYAVPTFAQEGTYHSVPRSNALLFSDHQPVNLTVRLPRSTGTPVPLSLHIEKYPLSWSSGLIGQIGDAVIGYCGWLVTKNVHYWILGSLLLYLLLKIL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
7Ubiquitination-MNKTNWKVSVTTFN
-CCCCCCEEEEEEEC		27.0517644757
17AcetylationVTTFNCGKEFPVENS
EEEECCCCEECCCCC		59.3824489116
17UbiquitinationVTTFNCGKEFPVENS
EEEECCCCEECCCCC		59.3817644757
25UbiquitinationEFPVENSKAIVKQLL
EECCCCCHHHHHHHH		54.4317644757
85UbiquitinationAVNCLNEKVSATQGD
HHHHHCCCCCCCCCC		40.1817644757
118UbiquitinationLYNNNALKVKDDILK
EECCCCEEECHHHHH		44.8417644757
120UbiquitinationNNNALKVKDDILKRN
CCCCEEECHHHHHHC		48.3617644757
125UbiquitinationKVKDDILKRNGKCGW
EECHHHHHHCCCEEC		44.1217644757
195UbiquitinationVCDSEVAKSDHFFFL
HCCHHHHHCCCEEEE		62.6917644757
210PhosphorylationGDLNFRVTSTYDPTT
CCCEEEEEEEECCCC		15.8721126336
211PhosphorylationDLNFRVTSTYDPTTN
CCEEEEEEEECCCCC		23.3227017623
212PhosphorylationLNFRVTSTYDPTTNY
CEEEEEEEECCCCCC		23.6827017623
220PhosphorylationYDPTTNYSSTTTLRR
ECCCCCCCCHHHHHH		24.2328889911
221PhosphorylationDPTTNYSSTTTLRRL
CCCCCCCCHHHHHHH		21.2923749301
240UbiquitinationEELNLLRKGEDEPLC
HHHHHHHCCCCCCCC		67.6217644757
262AcetylationITFPPTYKFKLFEKE
EECCCCEEEEEEEEC		38.2024489116
264UbiquitinationFPPTYKFKLFEKETY
CCCCEEEEEEEECCC		48.3817644757
268UbiquitinationYKFKLFEKETYNTKR
EEEEEEEECCCCCCC		48.2817644757
274UbiquitinationEKETYNTKRIPSWCD
EECCCCCCCCCHHHH		44.7017644757
286UbiquitinationWCDRILYKSYAVPTF
HHHHHHHHHCCCCCC		33.2817644757
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of INP54_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of INP54_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of INP54_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CAPZA_YEASTCAP1physical
16554755
TM115_YEASTYOL107Wgenetic
16269340
MSMO_YEASTERG25genetic
16269340
SIL1_YEASTSIL1genetic
16269340
IZH4_YEASTIZH4genetic
16269340
PGA3_YEASTPGA3genetic
16269340
GST1_YEASTGTT1genetic
16269340
PEX29_YEASTPEX29physical
18719252
TPS2_YEASTTPS2genetic
19269370
RAS2_YEASTRAS2genetic
19269370
6P22_YEASTPFK27genetic
19269370
XRN1_YEASTXRN1genetic
20526336
VAC8_YEASTVAC8genetic
20526336
FADH_YEASTSFA1genetic
21623372
FABD_YEASTMCT1genetic
21623372
OCA5_YEASTOCA5genetic
27708008
RL8A_YEASTRPL8Agenetic
27708008
MLP1_YEASTMLP1genetic
27708008
PNPH_YEASTPNP1genetic
27708008
RAD10_YEASTRAD10genetic
27708008
RS8A_YEASTRPS8Agenetic
27708008
RS8B_YEASTRPS8Agenetic
27708008
BRE4_YEASTBRE4genetic
27708008
ARO1_YEASTARO1genetic
27708008
IVY1_YEASTIVY1genetic
27708008
PSP1_YEASTPSP1genetic
27708008
IRC4_YEASTIRC4genetic
27708008
ROG3_YEASTROG3genetic
27708008
RL29_YEASTRPL29genetic
27708008
THP2_YEASTTHP2genetic
27708008
VPS53_YEASTVPS53genetic
27708008
CTK1_YEASTCTK1genetic
27708008
KAPC_YEASTTPK3genetic
27708008
UTH1_YEASTUTH1genetic
27708008
RSSA2_YEASTRPS0Bgenetic
27708008
PFD6_YEASTYKE2genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of INP54_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-220 AND SER-221, ANDMASS SPECTROMETRY.

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