CAPZA_YEAST - dbPTM
CAPZA_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CAPZA_YEAST
UniProt AC P28495
Protein Name F-actin-capping protein subunit alpha
Gene Name CAP1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 268
Subcellular Localization
Protein Description F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments..
Protein Sequence MSSSKFEEVINKIINDSPPGELREVYDDLIKITSENSKNTILDAIENYNVQNCIPIEVNGNSVIISKYNKEGAKFFDPVNSVIFSVNHLERKGLDIEPYEFTHAKIEKGQLKELHDKLHEYLLQSFPGDVSFAVYPVPEEISKISIIIVSTKYNPNNFWNGHWRSSYIYDLETRELSGQISTQVHYYEDGNVSFQSGKDINQSNVDDVVCTIRDIETNFENDLDLSFFDLNEKQFKALRRRLPVTRSKINWGSAIGSYRLGKNAAEGK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MSSSKFEEV
------CCCHHHHHH		43.2322814378
2Phosphorylation------MSSSKFEEV
------CCCHHHHHH		43.2328152593
17PhosphorylationINKIINDSPPGELRE
HHHHHCCCCCCHHHH		28.6225752575
31AcetylationEVYDDLIKITSENSK
HHHHHHHHHCCCCCC		47.4224489116
74UbiquitinationKYNKEGAKFFDPVNS
ECCCCCCCCCCCHHH		58.3717644757
81PhosphorylationKFFDPVNSVIFSVNH
CCCCCHHHEEEEEHH		19.4721440633
85PhosphorylationPVNSVIFSVNHLERK
CHHHEEEEEHHHHHC		15.7524961812
92UbiquitinationSVNHLERKGLDIEPY
EEHHHHHCCCCCCCC		55.2217644757
247PhosphorylationRRLPVTRSKINWGSA
HHCCCCHHHCCCCHH		28.6421440633
248UbiquitinationRLPVTRSKINWGSAI
HCCCCHHHCCCCHHH		36.4517644757
248AcetylationRLPVTRSKINWGSAI
HCCCCHHHCCCCHHH		36.4525381059
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CAPZA_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CAPZA_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CAPZA_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CAPZB_YEASTCAP2physical
11805826
TDA2_YEASTTDA2physical
11805826
AIM21_YEASTAIM21physical
11805826
CAPZB_YEASTCAP2physical
11489916
GIC2_YEASTGIC2physical
11489916
BSP1_YEASTBSP1physical
11489916
CAPZB_YEASTCAP2genetic
1447293
CAPZB_YEASTCAP2physical
16429126
TDA2_YEASTTDA2physical
16429126
AIM21_YEASTAIM21physical
16429126
RV161_YEASTRVS161genetic
18931302
PMP3_YEASTPMP3genetic
18931302
MNN10_YEASTMNN10genetic
18931302
ATC1_YEASTPMR1genetic
18931302
FLR1_YEASTFLR1genetic
9235926
SRB8_YEASTSRB8genetic
19325107
CAPZB_YEASTCAP2physical
20826334
AIM3_YEASTAIM3genetic
21035341
CHS1_YEASTCHS1genetic
20526336
YPT31_YEASTYPT31genetic
20526336
CLA4_YEASTCLA4genetic
20526336
HKR1_YEASTHKR1genetic
20526336
RV161_YEASTRVS161genetic
20526336
RV167_YEASTRVS167genetic
20526336
SRN2_YEASTSRN2genetic
20526336
SPO14_YEASTSPO14genetic
20526336
IST2_YEASTIST2genetic
20526336
AIM3_YEASTAIM3genetic
20526336
AIP1_YEASTAIP1genetic
23333351
COFI_YEASTCOF1genetic
23333351
SWI6_YEASTSWI6genetic
27708008
CDC24_YEASTCDC24genetic
27708008
CALM_YEASTCMD1genetic
27708008
SCC1_YEASTMCD1genetic
27708008
ACT_YEASTACT1genetic
27708008
PAN1_YEASTPAN1genetic
27708008
EXO70_YEASTEXO70genetic
27708008
COFI_YEASTCOF1genetic
27708008
CAP_YEASTSRV2genetic
27708008
PROF_YEASTPFY1genetic
27708008
VPS8_YEASTVPS8genetic
27708008
ATC3_YEASTDRS2genetic
27708008
YAJ9_YEASTYAR029Wgenetic
27708008
SLA1_YEASTSLA1genetic
27708008
IST2_YEASTIST2genetic
27708008
AIM3_YEASTAIM3genetic
27708008
BSD2_YEASTBSD2genetic
27708008
RV161_YEASTRVS161genetic
27708008
ABP1_YEASTABP1genetic
27708008
PP2C1_YEASTPTC1genetic
27708008
NUM1_YEASTNUM1genetic
27708008
NBP2_YEASTNBP2genetic
27708008
PMP3_YEASTPMP3genetic
27708008
RV167_YEASTRVS167genetic
27708008
SHE9_YEASTSHE9genetic
27708008
SNF1_YEASTSNF1genetic
27708008
PAC11_YEASTPAC11genetic
27708008
BEM2_YEASTBEM2genetic
27708008
ASK10_YEASTASK10genetic
27708008
SMI1_YEASTSMI1genetic
27708008
TNA1_YEASTTNA1genetic
27708008
BBC1_YEASTBBC1genetic
27708008
LDB18_YEASTLDB18genetic
27708008
MMR1_YEASTMMR1genetic
27708008
ARPC3_YEASTARC18genetic
27708008
AIP1_YEASTAIP1genetic
27708008
PABC_YEASTABZ2genetic
27708008
JNM1_YEASTJNM1genetic
27708008
LIS1_YEASTPAC1genetic
27708008
YP066_YEASTRGL1genetic
27708008
BEM4_YEASTBEM4genetic
27708008
NIP80_YEASTNIP100genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CAPZA_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-17, AND MASSSPECTROMETRY.

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