| UniProt ID | CHS1_YEAST | |
|---|---|---|
| UniProt AC | P08004 | |
| Protein Name | Chitin synthase 1 | |
| Gene Name | CHS1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1131 | |
| Subcellular Localization |
Cell membrane Multi-pass membrane protein. |
|
| Protein Description | Septum formation and repair, especially under certain adverse conditions.. | |
| Protein Sequence | MSDQNNRSRNEYHSNRKNEPSYELQNAHSGLFHSSNEELTNRNQRYTNQNASMGSFTPVQSLQFPEQSQQTNMLYNGDDGNNNTINDNERDIYGGFVNHHRQRPPPATAEYNDVFNTNSQQLPSEHQYNNVPSYPLPSINVIQTTPELIHNGSQTMATPIERPFFNENDYYYNNRNSRTSPSIASSSDGYADQEARPILEQPNNNMNSGNIPQYHDQPFGYNNGYHGLQAKDYYDDPEGGYIDQRGDDYQINSYLGRNGEMVDPYDYENSLRHMTPMERREYLHDDSRPVNDGKEELDSVKSGYSHRDLGEYDKDDFSRDDEYDDLNTIDKLQFQANGVPASSSVSSIGSKESDIIVSNDNLTANRALKRSGTEIRKFKLWNGNFVFDSPISKTLLDQYATTTENANTLPNEFKFMRYQAVTCEPNQLAEKNFTVRQLKYLTPRETELMLVVTMYNEDHILLGRTLKGIMDNVKYMVKKKNSSTWGPDAWKKIVVCIISDGRSKINERSLALLSSLGCYQDGFAKDEINEKKVAMHVYEHTTMINITNISESEVSLECNQGTVPIQLLFCLKEQNQKKINSHRWAFEGFAELLRPNIVTLLDAGTMPGKDSIYQLWREFRNPNVGGACGEIRTDLGKRFVKLLNPLVASQNFEYKMSNILDKTTESNFGFITVLPGAFSAYRFEAVRGQPLQKYFYGEIMENEGFHFFSSNMYLAEDRILCFEVVTKKNCNWILKYCRSSYASTDVPERVPEFILQRRRWLNGSFFASVYSFCHFYRVWSSGHNIGRKLLLTVEFFYLFFNTLISWFSLSSFFLVFRILTVSIALAYHSAFNVLSVIFLWLYGICTLSTFILSLGNKPKSTEKFYVLTCVIFAVMMIYMIFCSIFMSVKSFQNILKNDTISFEGLITTEAFRDIVISLGSTYCLYLISSIIYLQPWHMLTSFIQYILLSPSYINVLNIYAFCNVHDLSWGTKGAMANPLGKINTTEDGTFKMEVLVSSSEIQANYDKYLKVLNDFDPKSESRPTEPSYDEKKTGYYANVRSLVIIFWVITNFIIVAVVLETGGIADYIAMKSISTDDTLETAKKAEIPLMTSKASIYFNVILWLVALSALIRFIGCSIYMIVRFFKKVTFR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 17 | Ubiquitination | NEYHSNRKNEPSYEL HHHCCCCCCCCCHHH | 70.66 | 17644757 | |
| 21 | Phosphorylation | SNRKNEPSYELQNAH CCCCCCCCHHHHHCC | 25.68 | 19779198 | |
| 22 | Phosphorylation | NRKNEPSYELQNAHS CCCCCCCHHHHHCCC | 31.23 | 19779198 | |
| 29 | Phosphorylation | YELQNAHSGLFHSSN HHHHHCCCCCCCCCH | 34.48 | 19795423 | |
| 34 | Phosphorylation | AHSGLFHSSNEELTN CCCCCCCCCHHHHHC | 27.76 | 17330950 | |
| 35 | Phosphorylation | HSGLFHSSNEELTNR CCCCCCCCHHHHHCC | 39.42 | 17330950 | |
| 40 | Phosphorylation | HSSNEELTNRNQRYT CCCHHHHHCCCHHCC | 35.10 | 17330950 | |
| 179 | Phosphorylation | YNNRNSRTSPSIASS CCCCCCCCCCCCCCC | 44.82 | 27017623 | |
| 180 | Phosphorylation | NNRNSRTSPSIASSS CCCCCCCCCCCCCCC | 18.62 | 27017623 | |
| 182 | Phosphorylation | RNSRTSPSIASSSDG CCCCCCCCCCCCCCC | 30.47 | 28889911 | |
| 187 | Phosphorylation | SPSIASSSDGYADQE CCCCCCCCCCCCCCC | 32.34 | 28889911 | |
| 231 | Ubiquitination | GYHGLQAKDYYDDPE CCCCCCCCCCCCCCC | 33.05 | 17644757 | |
| 267 | Phosphorylation | EMVDPYDYENSLRHM CCCCCCCCCCCHHCC | 15.92 | 21440633 | |
| 270 | Phosphorylation | DPYDYENSLRHMTPM CCCCCCCCHHCCCHH | 18.16 | 17330950 | |
| 275 | Phosphorylation | ENSLRHMTPMERREY CCCHHCCCHHHHHHH | 17.23 | 23749301 | |
| 299 | Phosphorylation | DGKEELDSVKSGYSH CCHHHHHHCCCCCCC | 44.03 | 17330950 | |
| 302 | Phosphorylation | EELDSVKSGYSHRDL HHHHHCCCCCCCCCC | 40.59 | 19823750 | |
| 304 | Phosphorylation | LDSVKSGYSHRDLGE HHHCCCCCCCCCCCC | 14.37 | 19779198 | |
| 305 | Phosphorylation | DSVKSGYSHRDLGEY HHCCCCCCCCCCCCC | 18.64 | 17287358 | |
| 312 | Phosphorylation | SHRDLGEYDKDDFSR CCCCCCCCCCCCCCC | 26.88 | 19823750 | |
| 318 | Phosphorylation | EYDKDDFSRDDEYDD CCCCCCCCCCCCCCC | 41.62 | 17330950 | |
| 323 | Phosphorylation | DFSRDDEYDDLNTID CCCCCCCCCCCCHHH | 23.04 | 19823750 | |
| 328 | Phosphorylation | DEYDDLNTIDKLQFQ CCCCCCCHHHHHHHH | 37.54 | 22369663 | |
| 342 | Phosphorylation | QANGVPASSSVSSIG HHCCCCCCCCCCCCC | 19.64 | 21440633 | |
| 343 | Phosphorylation | ANGVPASSSVSSIGS HCCCCCCCCCCCCCC | 36.54 | 21440633 | |
| 344 | Phosphorylation | NGVPASSSVSSIGSK CCCCCCCCCCCCCCC | 24.43 | 20377248 | |
| 346 | Phosphorylation | VPASSSVSSIGSKES CCCCCCCCCCCCCCC | 20.41 | 21551504 | |
| 347 | Phosphorylation | PASSSVSSIGSKESD CCCCCCCCCCCCCCC | 28.90 | 20377248 | |
| 350 | Phosphorylation | SSVSSIGSKESDIIV CCCCCCCCCCCCEEE | 31.42 | 20377248 | |
| 351 | Ubiquitination | SVSSIGSKESDIIVS CCCCCCCCCCCEEEE | 56.90 | 17644757 | |
| 353 | Phosphorylation | SSIGSKESDIIVSND CCCCCCCCCEEEECC | 37.53 | 21440633 | |
| 358 | Phosphorylation | KESDIIVSNDNLTAN CCCCEEEECCCHHHC | 28.23 | 27214570 | |
| 363 | Phosphorylation | IVSNDNLTANRALKR EEECCCHHHCHHHHH | 28.30 | 29688323 | |
| 371 | Phosphorylation | ANRALKRSGTEIRKF HCHHHHHCCCEEEEE | 48.78 | 27717283 | |
| 373 | Phosphorylation | RALKRSGTEIRKFKL HHHHHCCCEEEEEEE | 29.50 | 27717283 | |
| 379 | Ubiquitination | GTEIRKFKLWNGNFV CCEEEEEEEECCCEE | 56.48 | 17644757 | |
| 393 | Ubiquitination | VFDSPISKTLLDQYA EECCCCCHHHHHHHC | 43.86 | 17644757 | |
| 414 | Ubiquitination | NTLPNEFKFMRYQAV CCCCCCCCEEEEEEE | 31.88 | 17644757 | |
| 431 | Ubiquitination | EPNQLAEKNFTVRQL CHHHHHHCCCEEEEE | 52.32 | 23749301 | |
| 431 | Acetylation | EPNQLAEKNFTVRQL CHHHHHHCCCEEEEE | 52.32 | 24489116 | |
| 439 | Ubiquitination | NFTVRQLKYLTPRET CCEEEEECCCCCCCC | 29.85 | 23749301 | |
| 492 | Ubiquitination | WGPDAWKKIVVCIIS CCCCHHHCEEEEEEC | 29.99 | 17644757 | |
| 525 | Ubiquitination | CYQDGFAKDEINEKK CCCCCCCCCCCCHHH | 54.34 | 17644757 | |
| 531 | Ubiquitination | AKDEINEKKVAMHVY CCCCCCHHHHHHEEE | 48.32 | 17644757 | |
| 532 | Ubiquitination | KDEINEKKVAMHVYE CCCCCHHHHHHEEEE | 29.10 | 17644757 | |
| 641 | Ubiquitination | DLGKRFVKLLNPLVA HHHHHHHHHHHHHHH | 44.54 | 17644757 | |
| 655 | Ubiquitination | ASQNFEYKMSNILDK HCCCCCEEHHHHHHH | 28.75 | 17644757 | |
| 662 | Ubiquitination | KMSNILDKTTESNFG EHHHHHHHCCCCCCC | 54.63 | 17644757 | |
| 981 | Ubiquitination | AMANPLGKINTTEDG CCCCCCCCEEECCCC | 40.23 | 23749301 | |
| 1018 | Ubiquitination | VLNDFDPKSESRPTE HHHCCCCCCCCCCCC | 69.56 | 23749301 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CHS1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CHS1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CHS1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-270 AND SER-358, ANDMASS SPECTROMETRY. | |
| "Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-305, AND MASSSPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-34; SER-270; SER-299;SER-318 AND THR-328, AND MASS SPECTROMETRY. | |
| "A proteomics approach to understanding protein ubiquitination."; Peng J., Schwartz D., Elias J.E., Thoreen C.C., Cheng D.,Marsischky G., Roelofs J., Finley D., Gygi S.P.; Nat. Biotechnol. 21:921-926(2003). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-328, AND MASSSPECTROMETRY. | |
