| UniProt ID | PP4R3_YEAST | |
|---|---|---|
| UniProt AC | P40164 | |
| Protein Name | Serine/threonine-protein phosphatase 4 regulatory subunit 3 | |
| Gene Name | PSY2 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 858 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Core regulatory subunit of the histone H2A phosphatase complex, which dephosphorylates H2AS128ph (gamma-H2A) that has been displaced from sites of DNA lesions in the double-stranded DNA break repair process. Dephosphorylation is necessary for efficient recovery from the DNA damage checkpoint.. | |
| Protein Sequence | MSLPGTPTTSPTPMDEDTEQAVSVNTEPKRVKVYILENNEWKDTGTGFCIGEVDEGKFAYLVVSDEDSPTETLLKSKLEGNIEYQRQEETLIVWKDLGGKDIALSFEESMGCDTLCEFIVHVQRNIESNISLVTVKSSDNGLGSVHDIITGPVTLPSNDQQQNSQTLLEALKILNENTSFDFLKNETIEFILQSNYIDTLISHFHKAEEEKIPKDLFLLSNIIKTLILYNKRDILESMVEDDRIMGIVGILEYDTEYPTSKANHRKYLGSKGPNFKEVIPLENEDLKIIMKKCFRLQFLKDVVLVRFLDDHNFNLISEIVMDLETCIIDFLQVGTFLDRLIELYDTKTLPESSSEKEKFVQKRKDGIRLLQQCVQMSINLDAVDRSKFYKTLVRKGLFKVLDYAFHMETDSNVRILATDTIITIIEHDILLIHNVQNEDSFKRQHKSAPDDKSSHRKYPQDYSSSTDSKLLLILSTILLSDRSPGLREQVVQALNTLLHPEGCVGNGEGSYDLMGRSNYEAKNTSEDFPSFSYGLNSDSINLNNYHYSSDEMNNLEPESESEFQVMEYFANFYNKIAPILFGPLIKKDITTEMAEIDGQIEKVTKDDLLLIHLVKLVSFVCTEHDRVLSRRFILENGILDSVSKLIGGNHMMQLRLTAVRCIKNLMCLDDKYYHRYMISKNLYAPVFKLFQENIDKNNLANSCIQDFFRIIITECRAYQSDGHNRKEKTNGSYDGNGNDVKTNVNNNRTNFTILNKYLVQTYGDVLRKATDIPFIQDMLETGEENQPDHSSFENSIEGGNDISVNMSTDGFASNHLEDIDIKNVKRLHSEIEHFENDPHYSGDQLAFKKSVDQMNAST | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MSLPGTPTT ------CCCCCCCCC | 43.18 | 19823750 | |
| 6 | Phosphorylation | --MSLPGTPTTSPTP --CCCCCCCCCCCCC | 18.60 | 19823750 | |
| 8 | Phosphorylation | MSLPGTPTTSPTPMD CCCCCCCCCCCCCCC | 39.48 | 19823750 | |
| 9 | Phosphorylation | SLPGTPTTSPTPMDE CCCCCCCCCCCCCCC | 33.63 | 19823750 | |
| 10 | Phosphorylation | LPGTPTTSPTPMDED CCCCCCCCCCCCCCC | 29.29 | 19823750 | |
| 12 | Phosphorylation | GTPTTSPTPMDEDTE CCCCCCCCCCCCCCC | 30.89 | 19823750 | |
| 18 | Phosphorylation | PTPMDEDTEQAVSVN CCCCCCCCCCCCCCC | 28.13 | 19823750 | |
| 23 | Phosphorylation | EDTEQAVSVNTEPKR CCCCCCCCCCCCCCE | 16.80 | 19823750 | |
| 26 | Phosphorylation | EQAVSVNTEPKRVKV CCCCCCCCCCCEEEE | 52.05 | 19823750 | |
| 137 | Phosphorylation | ISLVTVKSSDNGLGS EEEEEEECCCCCCCC | 38.29 | 21440633 | |
| 144 | Phosphorylation | SSDNGLGSVHDIITG CCCCCCCCCEEEEEC | 22.71 | 20377248 | |
| 150 | Phosphorylation | GSVHDIITGPVTLPS CCCEEEEECCCCCCC | 35.45 | 23749301 | |
| 276 | Acetylation | GSKGPNFKEVIPLEN CCCCCCHHHEEECCC | 58.68 | 24489116 | |
| 463 | Phosphorylation | RKYPQDYSSSTDSKL CCCCCCCCCCHHHHH | 26.54 | 29734811 | |
| 464 | Phosphorylation | KYPQDYSSSTDSKLL CCCCCCCCCHHHHHH | 30.91 | 29734811 | |
| 466 | Phosphorylation | PQDYSSSTDSKLLLI CCCCCCCHHHHHHHH | 46.36 | 29734811 | |
| 590 | Phosphorylation | PLIKKDITTEMAEID HHCCCCCCHHHHHHC | 27.17 | 19823750 | |
| 591 | Phosphorylation | LIKKDITTEMAEIDG HCCCCCCHHHHHHCC | 24.89 | 19823750 | |
| 604 | Phosphorylation | DGQIEKVTKDDLLLI CCCEEECCHHHHHHH | 39.56 | 19823750 | |
| 605 | Acetylation | GQIEKVTKDDLLLIH CCEEECCHHHHHHHH | 52.84 | 24489116 | |
| 672 | Phosphorylation | LMCLDDKYYHRYMIS HHCCCCHHHHHHHHC | 16.11 | 19823750 | |
| 673 | Phosphorylation | MCLDDKYYHRYMISK HCCCCHHHHHHHHCC | 5.88 | 19823750 | |
| 676 | Phosphorylation | DDKYYHRYMISKNLY CCHHHHHHHHCCCCC | 5.86 | 19823750 | |
| 679 | Phosphorylation | YYHRYMISKNLYAPV HHHHHHHCCCCCHHH | 10.04 | 19823750 | |
| 683 | Phosphorylation | YMISKNLYAPVFKLF HHHCCCCCHHHHHHH | 20.46 | 19823750 | |
| 732 | Phosphorylation | RKEKTNGSYDGNGND CCCCCCCCCCCCCCC | 23.32 | 23749301 | |
| 829 | Phosphorylation | KNVKRLHSEIEHFEN HHHHHHHHHHHHHCC | 44.88 | 30377154 | |
| 848 | Acetylation | SGDQLAFKKSVDQMN CCCHHHHHHHHHHHH | 38.23 | 25381059 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PP4R3_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PP4R3_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PP4R3_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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