UniProt ID | TIP41_YEAST | |
---|---|---|
UniProt AC | Q12199 | |
Protein Name | Type 2A phosphatase activator TIP41 | |
Gene Name | TIP41 | |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
Sequence Length | 356 | |
Subcellular Localization | Cytoplasm. Nucleus. | |
Protein Description | Involved in negative regulation of the TOR signaling pathway in response to type of available nitrogen source. Indirectly activates the PP2A phosphatase SIT4 via interaction with its suppressor TAP42. This interaction is enhanced under nitrogen limitation conditions. Also has a role in regulation of NPR1 in response to nitrogen limitation.. | |
Protein Sequence | MSKRNTPPLRSSGINTIQINAAREMHAQTVRARRMPMPTSGITTPSVQPTAAPATPPRHICNNPNNPQCLHCGSVIIPSPRATLPLEDNPSISINDWTISSRKKPILNSQELDIWENEKLKGLTLPEMIFGNNYIRIENSKQHWSIEFNALDALKEVQLQDSGIRVAYSNDWINSKKRQNSTNGAQRFTNDVNDDSLNIIHKYDWTYTTRYKGTESSPESKFRLDNDQKLPLDKLAVHDKILFYDDMILFEDELADNGISILNVKIRVMNERLLLLSRFFLRVDDVLVRVYDTRIYVEFDENVVIRESKEFEGKYQDVLAKHRLSQSHDPKAALRDSNWVAQNTPMIKRQCEIIQF | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
6 | Phosphorylation | --MSKRNTPPLRSSG --CCCCCCCCCCCCC | 30.25 | 17563356 | |
40 | Phosphorylation | RRMPMPTSGITTPSV HCCCCCCCCCCCCCC | 23.48 | 19779198 | |
50 | Phosphorylation | TTPSVQPTAAPATPP CCCCCCCCCCCCCCC | 20.54 | 27017623 | |
55 | Phosphorylation | QPTAAPATPPRHICN CCCCCCCCCCCCCCC | 32.54 | 27738172 | |
74 | Phosphorylation | PQCLHCGSVIIPSPR CCCCCCCCEEECCCC | 18.61 | 19779198 | |
79 | Phosphorylation | CGSVIIPSPRATLPL CCCEEECCCCCCCCC | 19.33 | 25704821 | |
169 | Phosphorylation | SGIRVAYSNDWINSK CCCEEEEECCCCCCC | 20.69 | 21126336 | |
214 | Phosphorylation | YTTRYKGTESSPESK EEEECCCCCCCCCHH | 28.66 | 27017623 | |
216 | Phosphorylation | TRYKGTESSPESKFR EECCCCCCCCCHHCC | 51.54 | 27017623 | |
217 | Phosphorylation | RYKGTESSPESKFRL ECCCCCCCCCHHCCC | 26.84 | 27017623 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TIP41_YEAST !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TIP41_YEAST !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TIP41_YEAST !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
PP4C_YEAST | PPH3 | physical | 16085932 | |
PP2A1_YEAST | PPH21 | physical | 16085932 | |
PP2A2_YEAST | PPH22 | physical | 16085932 | |
PP4R2_YEAST | PSY4 | physical | 16085932 | |
PP4R3_YEAST | PSY2 | physical | 16085932 | |
RPN5_YEAST | RPN5 | physical | 16554755 | |
RPN9_YEAST | RPN9 | physical | 16554755 | |
PP2A1_YEAST | PPH21 | physical | 11283351 | |
PP2A2_YEAST | PPH22 | physical | 11283351 | |
PP2A4_YEAST | PPG1 | physical | 11283351 | |
TAP42_YEAST | TAP42 | physical | 17846631 | |
PP2A1_YEAST | PPH21 | physical | 17846631 | |
PP2A2_YEAST | PPH22 | physical | 17846631 | |
SA155_YEAST | SAP155 | genetic | 11741537 | |
YPK9_YEAST | YPK9 | genetic | 22457822 | |
PDP2_YEAST | PTC6 | genetic | 23704987 | |
ELP3_YEAST | ELP3 | genetic | 28357221 | |
URM1_YEAST | URM1 | genetic | 28357221 |
Kegg Drug | ||||||
---|---|---|---|---|---|---|
DrugBank | ||||||
There are no disease associations of PTM sites. |
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Phosphorylation | |
Reference | PubMed |
"A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-55, AND MASSSPECTROMETRY. | |
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-6, AND MASSSPECTROMETRY. |