MPH1_YEAST - dbPTM
MPH1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MPH1_YEAST
UniProt AC P40562
Protein Name ATP-dependent DNA helicase MPH1 {ECO:0000305}
Gene Name MPH1 {ECO:0000303|PubMed:10628851}
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 993
Subcellular Localization Nucleus .
Protein Description ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. [PubMed: 10880470]
Protein Sequence MASADDYFSDFEDDELDKLYEKAINKSVKETITRRAVPVQKDLHDNVLPGQKTVYEEIQRDVSFGPTHHELDYDALSFYVYPTNYEVRDYQYTIVHKSLFQNTLCAIPTGMGKTFIASTVMLNYFRWTKKAKIIFTAPTRPLVAQQIKACLGITGIPSDQTAILLDKSRKNREEIWANKRVFFATPQVVENDLKRGVLDPKDIVCLVIDEAHRATGSSAYTNVVKFIDRFNSSYRLLALTATPASDLEGVQEVVNNLDISKIEIRTEESMDIVKYMKKRKKEKIEVPLLLEIEDIIEQLGMAVKPVLQQAIELGIYEECDPSQINAFKAMQQSQKIIANPTIPEGIKWRNFFILQLLNNVGQMLKRLKIYGIRTFFNYFQNKCTEFTTKYNLKKSTNKIAAEFYYHPILKNIKNQCENYLSDPKFVGHGKLQCVRDELMDFFQKRGSDSRVIIFTELRESALEIVKFIDSVADDQIRPHIFIGQARAKEGFDEVKYTRKHAPKGRKKVERLHRQEQEKFLEAERTKRAANDKLERSARRTGSSEEAQISGMNQKMQKEVIHNFKKGEYNVLVCTSIGEEGLDIGEVDLIICYDTTSSPIKNIQRMGRTGRKRDGKIVLLFSSNESYKFERAMEDYSTLQALISKQCIDYKKSDRIIPEDIIPECHETLITINDENEIINEMEDVDEVIRYATQCMMGKKVKPKKAITKKKRVQENKKPKKFFMPDNVETSIVSASTLINKFLVNESGGKQLVTSNENPSKKRKIFKALDNLENDSTEEASSSLETEDEEVSDDNNVFIAEGQNGCQKDLETAIIRTGESLTTLKPLHNFERPNMALFVNDCGLPTKIEKNVKDIRGNQHNLEKEKSCTVDKNNMVLSLDDWNFFRNRYIPEGVSFDVEPNFVQYTKGVKVPHCHKVSKIITLFNDESNDNKKRTIDMNYTKCLARGMLRDEKKFVKVNDKSQVDNNSVNHDSSQSFTLSNAELDDILGSDSDF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MASADDYFSD
-----CCCHHHHCCC		30.8229688323
7Phosphorylation-MASADDYFSDFEDD
-CCCHHHHCCCCCCH		12.9123607784
9PhosphorylationASADDYFSDFEDDEL
CCHHHHCCCCCCHHH		34.8528152593
41AcetylationRRAVPVQKDLHDNVL
HCCCCCCCCCCCCCC		63.5922865919
52AcetylationDNVLPGQKTVYEEIQ
CCCCCCCHHHHHHHH		45.9624489116
540PhosphorylationLERSARRTGSSEEAQ
HHHHHHHHCCCHHHH		35.5428889911
542PhosphorylationRSARRTGSSEEAQIS
HHHHHHCCCHHHHHC		33.6828889911
543PhosphorylationSARRTGSSEEAQISG
HHHHHCCCHHHHHCC		40.5830377154
776PhosphorylationDNLENDSTEEASSSL
HCCCCCCHHHHHHHC		40.4827257873
785PhosphorylationEASSSLETEDEEVSD
HHHHHCCCCCCCCCC		54.7727257873
819PhosphorylationAIIRTGESLTTLKPL
HHHHCCCCCCCCCCC		32.1521551504
866PhosphorylationHNLEKEKSCTVDKNN
CCHHCCCCEEECCCC		18.9928889911
868PhosphorylationLEKEKSCTVDKNNMV
HHCCCCEEECCCCCE		38.5428889911
989PhosphorylationELDDILGSDSDF---
HHHHHHCCCCCC---		30.4221551504
991PhosphorylationDDILGSDSDF-----
HHHHCCCCCC-----		100.0021551504
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MPH1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference
776TPhosphorylation

27257873
785TPhosphorylation

27257873
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MPH1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
UBC2_YEASTRAD6genetic
10880470
DPOZ_YEASTREV3genetic
10880470
RAD14_YEASTRAD14genetic
15126389
MAG_YEASTMAG1genetic
15126389
APN1_YEASTAPN1genetic
15126389
SGS1_YEASTSGS1genetic
15126389
RAD5_YEASTRAD5genetic
15126389
TRS85_YEASTTRS85genetic
17314980
COPE_YEASTSEC28genetic
17314980
HSP71_YEASTSSA1physical
19536198
PFD5_YEASTGIM5genetic
19547744
RAD51_YEASTRAD51genetic
19136626
SGS1_YEASTSGS1genetic
19136626
SRS2_YEASTSRS2genetic
19136626
RFA1_YEASTRFA1physical
18591428
SRS2_YEASTSRS2genetic
19918932
RAD51_YEASTRAD51genetic
19918932
RAD52_YEASTRAD52genetic
19918932
RAD55_YEASTRAD55genetic
19918932
RAD57_YEASTRAD57genetic
19918932
RAD24_YEASTRAD24genetic
19918932
SIZ1_YEASTSIZ1genetic
19918932
RAD54_YEASTRAD54genetic
19918932
MMS4_YEASTMMS4genetic
19918932
MUS81_YEASTMUS81genetic
19918932
SGS1_YEASTSGS1genetic
19918932
SMC5_YEASTSMC5physical
19995966
SGS1_YEASTSGS1genetic
20047969
SRS2_YEASTSRS2genetic
20347428
SHU1_YEASTSHU1genetic
20444977
MMS2_YEASTMMS2genetic
20444977
CSM2_YEASTCSM2genetic
20444977
RAD5_YEASTRAD5genetic
20444977
RAD51_YEASTRAD51genetic
20951099
SRS2_YEASTSRS2genetic
20008080
MEC3_YEASTMEC3genetic
20008080
RRM3_YEASTRRM3genetic
20008080
CHL1_YEASTCHL1genetic
20008080
SGS1_YEASTSGS1genetic
21138837
RAD51_YEASTRAD51genetic
21138837
RAD52_YEASTRAD52genetic
21138837
RAD5_YEASTRAD5genetic
21138837
RAD18_YEASTRAD18genetic
21138837
SLX4_YEASTSLX4genetic
17206143
CLA4_YEASTCLA4genetic
17206143
SRS2_YEASTSRS2genetic
22696213
MHF1_YEASTMHF1genetic
22696213
MHF2_YEASTMHF2genetic
22696213
RAD18_YEASTRAD18genetic
22696213
PSO2_YEASTPSO2genetic
22696213
RAD51_YEASTRAD51genetic
22696213
PCNA_YEASTPOL30genetic
22696213
CDC13_YEASTCDC13genetic
22848695
STN1_YEASTSTN1genetic
22848695
KU70_YEASTYKU70genetic
22848695
SPO14_YEASTSPO14physical
22875988
MG101_YEASTMGM101physical
22912599
ELG1_YEASTELG1genetic
23624835
YEN1_YEASTYEN1genetic
24119400
RAD1_YEASTRAD1genetic
24119400
MUS81_YEASTMUS81genetic
24119400
RNH2C_YEASTRNH203genetic
24550002
RAD51_YEASTRAD51genetic
24550002
ATR_YEASTMEC1genetic
23783034
DPOZ_YEASTREV3genetic
25060101
SGS1_YEASTSGS1genetic
27075725
SMC5_YEASTSMC5physical
25439736
SRS2_YEASTSRS2genetic
25439736
MMS4_YEASTMMS4genetic
25439736
DPOZ_YEASTREV3genetic
27585847
REV1_YEASTREV1genetic
27585847
POLH_YEASTRAD30genetic
27585847
FEN1_YEASTRAD27genetic
27585847
DNA2_YEASTDNA2genetic
27585847
SGS1_YEASTSGS1genetic
27585847
MUS81_YEASTMUS81genetic
27585847
SRS2_YEASTSRS2genetic
27585847
FKH1_YEASTFKH1physical
27257873
RFA1_YEASTRFA1physical
27257873
SMC5_YEASTSMC5physical
27257873
MHF2_YEASTMHF2physical
27257873
YM22_YEASTYMR144Wgenetic
27257873
STP1_YEASTSTP1genetic
27708008
YP014_YEASTYPL014Wgenetic
27708008
PRM4_YEASTPRM4genetic
27708008
SCC1_YEASTMCD1genetic
27708008
DPOD_YEASTPOL3genetic
27708008
CDC53_YEASTCDC53genetic
27708008
RSP5_YEASTRSP5genetic
27708008
CDC4_YEASTCDC4genetic
27708008
RPN11_YEASTRPN11genetic
27708008
ERG26_YEASTERG26genetic
27708008
HSP77_YEASTSSC1genetic
27708008
SEC22_YEASTSEC22genetic
27708008
TAD3_YEASTTAD3genetic
27708008
TYSY_YEASTCDC21genetic
27708008
SEC62_YEASTSEC62genetic
27708008
TBF1_YEASTTBF1genetic
27708008
DIB1_YEASTDIB1genetic
27708008
H3_YEASTHHT1genetic
27708008
TAH1_YEASTTAH1genetic
27708008
SOL2_YEASTSOL2genetic
27708008
PBP4_YEASTPBP4genetic
27708008
MCH1_YEASTMCH1genetic
27708008
BAP3_YEASTBAP3genetic
27708008
IPT1_YEASTIPT1genetic
27708008
CSN9_YEASTCSN9genetic
27708008
ERD1_YEASTERD1genetic
27708008
GMC1_YEASTGMC1genetic
27708008
RAD4_YEASTRAD4genetic
27708008
WWM1_YEASTWWM1genetic
27708008
IES1_YEASTIES1genetic
27708008
PIB2_YEASTPIB2genetic
27708008
MON1_YEASTMON1genetic
27708008
MRM2_YEASTMRM2genetic
27708008
CUL3_YEASTCUL3genetic
27708008
TNA1_YEASTTNA1genetic
27708008
YHB7_YEASTYHL017Wgenetic
27708008
PUT2_YEASTPUT2genetic
27708008
HTD2_YEASTHTD2genetic
27708008
KC11_YEASTYCK1genetic
27708008
NIT1_YEASTNIT1genetic
27708008
LPLA_YEASTAIM22genetic
27708008
ILM1_YEASTILM1genetic
27708008
ELM1_YEASTELM1genetic
27708008
PFD6_YEASTYKE2genetic
27708008
YL297_YEASTYLR297Wgenetic
27708008
FKS1_YEASTFKS1genetic
27708008
YPT7_YEASTYPT7genetic
27708008
FKBP3_YEASTFPR3genetic
27708008
YMP8_YEASTYMR018Wgenetic
27708008
YM14_YEASTYMR130Wgenetic
27708008
DSK2_YEASTDSK2genetic
27708008
MSB4_YEASTMSB4genetic
27708008
HST3_YEASTHST3genetic
27708008
SFL1_YEASTSFL1genetic
27708008
FSH3_YEASTFSH3genetic
27708008
RS10A_YEASTRPS10Agenetic
27708008
SPS4_YEASTSPS4genetic
27708008
ATF1_YEASTATF1genetic
27708008
TRM44_YEASTTRM44genetic
27708008
THP3_YEASTTHP3genetic
27708008
MEC3_YEASTMEC3genetic
23783034
MHF2_YEASTMHF2physical
26966246
YG1T_YEASTYGR042Wphysical
26966246
MHF1_YEASTMHF1physical
26966246
YG1T_YEASTYGR042Wphysical
26966248
MG101_YEASTMGM101physical
26966248
RFA3_YEASTRFA3physical
26966248
RFA1_YEASTRFA1physical
26966248
RIM1_YEASTRIM1physical
26966248
RFA2_YEASTRFA2physical
26966248
RAD52_YEASTRAD52physical
26966248
FKH1_YEASTFKH1physical
26966248
YG1T_YEASTYGR042Wgenetic
26966248
DPOZ_YEASTREV3genetic
28334887
SMC5_YEASTSMC5physical
25956905
MHF1_YEASTMHF1genetic
25956905
MHF2_YEASTMHF2genetic
25956905
RNH2A_YEASTRNH201genetic
29281624
RNH1_YEASTRNH1genetic
29281624
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MPH1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-540 AND SER-542, ANDMASS SPECTROMETRY.

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