MCH1_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MCH1_YEAST
• UniProt AC: Q07376
• Protein Name: Probable transporter MCH1
• Gene Name: MCH1
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 486
• Subcellular Localization: Vacuole membrane ; Multi-pass membrane protein .
• Protein Description: Probable transporter. Does not act in the transport of monocarboxylic acids across the plasma membrane..
• Protein Sequence: MPLSKVEHYLSYHTRLLLPHVLSLQSSHRVAYIFSLLSAVSTGFITLISLYSQPWQKHLNYSSWQINTIASMTNLGMYLTPPILGMIADSHGPITLSLLAIIGFIPSYSYLAYVFNHPELSLGGNGDSSFNLSIICFVFIGISTSALYFSALLTCTKLYPHTKLLSISLPTTCYGISSVVGSQLLRIKWFWSSNASSSSSNSDLNLGRVFQTFALVYVVIGLLAWIATSVVSLLHFNEEQDNQKRLDDQTDVEQSPLLERSNHVQEKFTQTMLRIFSDPVTYILAVSILLSLGPLEMFIANMGSLTNLLVQLDAPTLSTKLLSTYALSSTFTRLLTGIVADFFAKKKISIKWILLTFLSLGVCAQLFLLKMTSSASPWGLVPTGSLVGIVYGGLFTVYPTLVLLVWGERSFGTVYGSLLIAPAIGSMIFCMLYAKFYDSRCMSGGGDLRNPSCISAVYKYSSIAFVVSAVLSAVVFWKLKSRKLRI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
60	N-linked_Glycosylation	QPWQKHLNYSSWQIN CHHHHHCCCCCHHHH	34.07	-
131	N-linked_Glycosylation	GNGDSSFNLSIICFV CCCCCCCCCCHHHHH	34.52	-
194	N-linked_Glycosylation	IKWFWSSNASSSSSN EEEEECCCCCCCCCC	38.02	-
250	Phosphorylation	QKRLDDQTDVEQSPL HHCCCCCCCHHHCHH	49.35	27214570
255	Phosphorylation	DQTDVEQSPLLERSN CCCCHHHCHHHHCCH	12.19	24961812
261	Phosphorylation	QSPLLERSNHVQEKF HCHHHHCCHHHHHHH	23.16	24961812
452	Phosphorylation	GGDLRNPSCISAVYK CCCCCCHHHHHHHHH	27.86	24930733
455	Phosphorylation	LRNPSCISAVYKYSS CCCHHHHHHHHHHHH	18.93	24930733
458	Phosphorylation	PSCISAVYKYSSIAF HHHHHHHHHHHHHHH	12.15	24930733

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MCH1_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MCH1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MCH1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SFG1_YEAST	SFG1	physical	16554755
ERP2_YEAST	ERP2	physical	16093310
PRM9_YEAST	PRM9	physical	16093310
PHO88_YEAST	PHO88	physical	16093310
MKAR_YEAST	IFA38	physical	16093310
ELO2_YEAST	ELO2	physical	16093310
SHR3_YEAST	SHR3	physical	16093310
PMT7_YEAST	PMT7	physical	16093310
VATL1_YEAST	VMA3	physical	16093310
MST27_YEAST	MST27	physical	16093310
CBP4_YEAST	CBP4	physical	16093310
VATO_YEAST	VMA16	physical	16093310
ELO3_YEAST	ELO3	physical	16093310
SEC59_YEAST	SEC59	physical	16093310
ERP4_YEAST	ERP4	physical	16093310
MAL32_YEAST	MAL32	genetic	27708008
UBX2_YEAST	UBX2	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-255, AND MASSSPECTROMETRY.
PubMed: 18407956