| UniProt ID | DPOZ_YEAST | |
|---|---|---|
| UniProt AC | P14284 | |
| Protein Name | DNA polymerase zeta catalytic subunit | |
| Gene Name | REV3 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1504 | |
| Subcellular Localization | Mitochondrion . Nucleus . | |
| Protein Description | Nonessential DNA polymerase. Required for DNA damage induced mutagenesis. Involved in DNA repair, mitochondrial DNA repair and translesion synthesis. Translesion synthesis in S.cerevisiae may use a specialized DNA polymerase that is not required for other DNA replicative processes. Has a role in the bypass of abasic (AP) sites. Highly inefficient in incorporating nucleotides opposite the AP site, but efficiently extends from nucleotides, particularly an A, inserted opposite the lesion.. | |
| Protein Sequence | MSRESNDTIQSDTVRSSSKSDYFRIQLNNQDYYMSKPTFLDPSHGESLPLNQFSQVPNIRVFGALPTGHQVLCHVHGILPYMFIKYDGQITDTSTLRHQRCAQVHKTLEVKIRASFKRKKDDKHDLAGDKLGNLNFVADVSVVKGIPFYGYHVGWNLFYKISLLNPSCLSRISELIRDGKIFGKKFEIYESHIPYLLQWTADFNLFGCSWINVDRCYFRSPVLNSILDIDKLTINDDLQLLLDRFCDFKCNVLSRRDFPRVGNGLIEIDILPQFIKNREKLQHRDIHHDFLEKLGDISDIPVKPYVSSARDMINELTMQREELSLKEYKEPPETKRHVSGHQWQSSGEFEAFYKKAQHKTSTFDGQIPNFENFIDKNQKFSAINTPYEALPQLWPRLPQIEINNNSMQDKKNDDQVNASFTEYEICGVDNENEGVKGSNIKSRSYSWLPESIASPKDSTILLDHQTKYHNTINFSMDCAMTQNMASKRKLRSSVSANKTSLLSRKRKKVMAAGLRYGKRAFVYGEPPFGYQDILNKLEDEGFPKIDYKDPFFSNPVDLENKPYAYAGKRFEISSTHVSTRIPVQFGGETVSVYNKPTFDMFSSWKYALKPPTYDAVQKWYNKVPSMGNKKTESQISMHTPHSKFLYKFASDVSGKQKRKKSSVHDSLTHLTLEIHANTRSDKIPDPAIDEVSMIIWCLEEETFPLDLDIAYEGIMIVHKASEDSTFPTKIQHCINEIPVMFYESEFEMFEALTDLVLLLDPDILSGFEIHNFSWGYIIERCQKIHQFDIVRELARVKCQIKTKLSDTWGYAHSSGIMITGRHMINIWRALRSDVNLTQYTIESAAFNILHKRLPHFSFESLTNMWNAKKSTTELKTVLNYWLSRAQINIQLLRKQDYIARNIEQARLIGIDFHSVYYRGSQFKVESFLIRICKSESFILLSPGKKDVRKQKALECVPLVMEPESAFYKSPLIVLDFQSLYPSIMIGYNYCYSTMIGRVREINLTENNLGVSKFSLPRNILALLKNDVTIAPNGVVYAKTSVRKSTLSKMLTDILDVRVMIKKTMNEIGDDNTTLKRLLNNKQLALKLLANVTYGYTSASFSGRMPCSDLADSIVQTGRETLEKAIDIIEKDETWNAKVVYGDTDSLFVYLPGKTAIEAFSIGHAMAERVTQNNPKPIFLKFEKVYHPSILISKKRYVGFSYESPSQTLPIFDAKGIETVRRDGIPAQQKIIEKCIRLLFQTKDLSKIKKYLQNEFFKIQIGKVSAQDFCFAKEVKLGAYKSEKTAPAGAVVVKRRINEDHRAEPQYKERIPYLVVKGKQGQLLRERCVSPEEFLEGENLELDSEYYINKILIPPLDRLFNLIGINVGNWAQEIVKSKRASTTTTKVENITRVGTSATCCNCGEELTKICSLQLCDDCLEKRSTTTLSFLIKKLKRQKEYQTLKTVCRTCSYRYTSDAGIENDHIASKCNSYDCPVFYSRVKAERYLRDNQSVQREEALISLNDW | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 111 | Ubiquitination | VHKTLEVKIRASFKR HHHHEEEEEHHHHHC | 19.66 | 21427232 | |
| 492 | Phosphorylation | ASKRKLRSSVSANKT HHHHHHHHHHHCCCH | 45.59 | 26447709 | |
| 493 | Phosphorylation | SKRKLRSSVSANKTS HHHHHHHHHHCCCHH | 17.41 | 26447709 | |
| 495 | Phosphorylation | RKLRSSVSANKTSLL HHHHHHHHCCCHHHH | 28.24 | 26447709 | |
| 499 | Phosphorylation | SSVSANKTSLLSRKR HHHHCCCHHHHHHHH | 25.14 | 26447709 | |
| 500 | Phosphorylation | SVSANKTSLLSRKRK HHHCCCHHHHHHHHH | 28.99 | 26447709 | |
| 503 | Phosphorylation | ANKTSLLSRKRKKVM CCCHHHHHHHHHHHH | 40.84 | 26447709 | |
| 1112 | Phosphorylation | PCSDLADSIVQTGRE CHHHHHHHHHHHCHH | 21.03 | 19779198 | |
| 1116 | Phosphorylation | LADSIVQTGRETLEK HHHHHHHHCHHHHHH | 27.58 | 19779198 | |
| 1120 | Phosphorylation | IVQTGRETLEKAIDI HHHHCHHHHHHHHHH | 38.57 | 19779198 | |
| 1154 | Phosphorylation | FVYLPGKTAIEAFSI EEECCCCCHHHHHHH | 38.49 | 27017623 | |
| 1160 | Phosphorylation | KTAIEAFSIGHAMAE CCHHHHHHHHHHHHH | 34.41 | 27017623 | |
| 1380 | Phosphorylation | IVKSKRASTTTTKVE HHHCCCCCCCCEEEE | 30.25 | 28889911 | |
| 1454 | Phosphorylation | RTCSYRYTSDAGIEN HHCCCEECCCCCCCC | 15.90 | 28889911 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of DPOZ_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of DPOZ_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of DPOZ_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
