| UniProt ID | HSC82_YEAST | |
|---|---|---|
| UniProt AC | P15108 | |
| Protein Name | ATP-dependent molecular chaperone HSC82 | |
| Gene Name | HSC82 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 705 | |
| Subcellular Localization | Cytoplasm. Mitochondrion. | |
| Protein Description | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved in cell cycle control and signal transduction such as CNA2. Undergoes a functional cycle that is linked to its ATPase activity (By similarity). Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Required for growth at high temperatures.. | |
| Protein Sequence | MAGETFEFQAEITQLMSLIINTVYSNKEIFLRELISNASDALDKIRYQALSDPKQLETEPDLFIRITPKPEEKVLEIRDSGIGMTKAELINNLGTIAKSGTKAFMEALSAGADVSMIGQFGVGFYSLFLVADRVQVISKNNEDEQYIWESNAGGSFTVTLDEVNERIGRGTVLRLFLKDDQLEYLEEKRIKEVIKRHSEFVAYPIQLLVTKEVEKEVPIPEEEKKDEEKKDEDDKKPKLEEVDEEEEEKKPKTKKVKEEVQELEELNKTKPLWTRNPSDITQEEYNAFYKSISNDWEDPLYVKHFSVEGQLEFRAILFIPKRAPFDLFESKKKKNNIKLYVRRVFITDEAEDLIPEWLSFVKGVVDSEDLPLNLSREMLQQNKIMKVIRKNIVKKLIEAFNEIAEDSEQFDKFYSAFAKNIKLGVHEDTQNRAALAKLLRYNSTKSVDELTSLTDYVTRMPEHQKNIYYITGESLKAVEKSPFLDALKAKNFEVLFLTDPIDEYAFTQLKEFEGKTLVDITKDFELEETDEEKAEREKEIKEYEPLTKALKDILGDQVEKVVVSYKLLDAPAAIRTGQFGWSANMERIMKAQALRDSSMSSYMSSKKTFEISPKSPIIKELKKRVDEGGAQDKTVKDLTNLLFETALLTSGFSLEEPTSFASRINRLISLGLNIDEDEETETAPEASTEAPVEEVPADTEMEEVD | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 5 | Phosphorylation | ---MAGETFEFQAEI ---CCCCCCHHHHHH | 27.78 | 30377154 | |
| 13 | Phosphorylation | FEFQAEITQLMSLII CHHHHHHHHHHHHHH | 13.73 | 30377154 | |
| 22 | Phosphorylation | LMSLIINTVYSNKEI HHHHHHHHHHCCHHH | 15.48 | 30377154 | |
| 25 | Phosphorylation | LIINTVYSNKEIFLR HHHHHHHCCHHHHHH | 36.77 | 30377154 | |
| 36 | Phosphorylation | IFLRELISNASDALD HHHHHHHHCHHHHHH | 38.68 | 28152593 | |
| 39 | Phosphorylation | RELISNASDALDKIR HHHHHCHHHHHHHHH | 27.89 | 21440633 | |
| 44 | Ubiquitination | NASDALDKIRYQALS CHHHHHHHHHHHHHC | 29.90 | 23749301 | |
| 47 | Phosphorylation | DALDKIRYQALSDPK HHHHHHHHHHHCCHH | 11.12 | 21126336 | |
| 51 | Phosphorylation | KIRYQALSDPKQLET HHHHHHHCCHHHCCC | 55.68 | 21440633 | |
| 54 | Acetylation | YQALSDPKQLETEPD HHHHCCHHHCCCCCC | 72.93 | 24489116 | |
| 54 | Succinylation | YQALSDPKQLETEPD HHHHCCHHHCCCCCC | 72.93 | 23954790 | |
| 54 | Ubiquitination | YQALSDPKQLETEPD HHHHCCHHHCCCCCC | 72.93 | 23749301 | |
| 67 | Phosphorylation | PDLFIRITPKPEEKV CCEEEECCCCCHHHC | 18.53 | 21440633 | |
| 69 | Ubiquitination | LFIRITPKPEEKVLE EEEECCCCCHHHCEE | 57.31 | 23749301 | |
| 73 | Acetylation | ITPKPEEKVLEIRDS CCCCCHHHCEEEHHC | 50.92 | 24489116 | |
| 73 | Ubiquitination | ITPKPEEKVLEIRDS CCCCCHHHCEEEHHC | 50.92 | 23749301 | |
| 80 | Phosphorylation | KVLEIRDSGIGMTKA HCEEEHHCCCCCCHH | 23.59 | 21440633 | |
| 86 | Ubiquitination | DSGIGMTKAELINNL HCCCCCCHHHHHHHH | 30.85 | 23749301 | |
| 98 | Ubiquitination | NNLGTIAKSGTKAFM HHHHHHHHHCHHHHH | 45.64 | 23749301 | |
| 155 | Phosphorylation | WESNAGGSFTVTLDE EECCCCCCEEEEHHH | 19.47 | 21440633 | |
| 178 | Ubiquitination | TVLRLFLKDDQLEYL CEEEEEECHHHHHHH | 52.50 | 23749301 | |
| 188 | Ubiquitination | QLEYLEEKRIKEVIK HHHHHHHHHHHHHHH | 50.47 | 24961812 | |
| 198 | Phosphorylation | KEVIKRHSEFVAYPI HHHHHHHHHHHCCEE | 36.44 | 21440633 | |
| 211 | Ubiquitination | PIQLLVTKEVEKEVP EEEEEEECCCCCCCC | 52.89 | 17644757 | |
| 249 | Acetylation | VDEEEEEKKPKTKKV CCHHHHHHCCCHHHH | 77.11 | 24489116 | |
| 249 | Ubiquitination | VDEEEEEKKPKTKKV CCHHHHHHCCCHHHH | 77.11 | 23749301 | |
| 250 | Acetylation | DEEEEEKKPKTKKVK CHHHHHHCCCHHHHH | 55.84 | 24489116 | |
| 250 | Ubiquitination | DEEEEEKKPKTKKVK CHHHHHHCCCHHHHH | 55.84 | 23749301 | |
| 252 | Ubiquitination | EEEEKKPKTKKVKEE HHHHHCCCHHHHHHH | 80.16 | 22817900 | |
| 254 | Ubiquitination | EEKKPKTKKVKEEVQ HHHCCCHHHHHHHHH | 62.79 | 22817900 | |
| 255 | Ubiquitination | EKKPKTKKVKEEVQE HHCCCHHHHHHHHHH | 64.86 | 22817900 | |
| 257 | Acetylation | KPKTKKVKEEVQELE CCCHHHHHHHHHHHH | 57.97 | 24489116 | |
| 257 | Succinylation | KPKTKKVKEEVQELE CCCHHHHHHHHHHHH | 57.97 | 23954790 | |
| 257 | Ubiquitination | KPKTKKVKEEVQELE CCCHHHHHHHHHHHH | 57.97 | 24961812 | |
| 268 | Acetylation | QELEELNKTKPLWTR HHHHHHHCCCCCCCC | 71.23 | 24489116 | |
| 268 | Ubiquitination | QELEELNKTKPLWTR HHHHHHHCCCCCCCC | 71.23 | 17644757 | |
| 270 | Ubiquitination | LEELNKTKPLWTRNP HHHHHCCCCCCCCCH | 39.46 | 23749301 | |
| 274 | Phosphorylation | NKTKPLWTRNPSDIT HCCCCCCCCCHHHCC | 28.40 | 24961812 | |
| 278 | Phosphorylation | PLWTRNPSDITQEEY CCCCCCHHHCCHHHH | 45.23 | 21551504 | |
| 281 | Phosphorylation | TRNPSDITQEEYNAF CCCHHHCCHHHHHHH | 34.61 | 28889911 | |
| 290 | Ubiquitination | EEYNAFYKSISNDWE HHHHHHHHHHCCCCC | 34.55 | 23749301 | |
| 291 | Phosphorylation | EYNAFYKSISNDWED HHHHHHHHHCCCCCC | 21.62 | 22369663 | |
| 293 | Phosphorylation | NAFYKSISNDWEDPL HHHHHHHCCCCCCCE | 35.51 | 22369663 | |
| 303 | Ubiquitination | WEDPLYVKHFSVEGQ CCCCEEEEEEEEECE | 25.94 | 23749301 | |
| 321 | Ubiquitination | RAILFIPKRAPFDLF EEEEEEECCCCCCHH | 57.27 | 23749301 | |
| 330 | Phosphorylation | APFDLFESKKKKNNI CCCCHHHCCCCCCCE | 42.30 | 25521595 | |
| 331 | Ubiquitination | PFDLFESKKKKNNIK CCCHHHCCCCCCCEE | 62.51 | 17644757 | |
| 332 | Ubiquitination | FDLFESKKKKNNIKL CCHHHCCCCCCCEEE | 77.56 | 17644757 | |
| 338 | Ubiquitination | KKKKNNIKLYVRRVF CCCCCCEEEEEEEEE | 35.57 | 23749301 | |
| 362 | Ubiquitination | PEWLSFVKGVVDSED HHHHHHHCCCCCCCC | 43.93 | 17644757 | |
| 367 | Phosphorylation | FVKGVVDSEDLPLNL HHCCCCCCCCCCCCC | 22.77 | 22369663 | |
| 375 | Phosphorylation | EDLPLNLSREMLQQN CCCCCCCCHHHHHHC | 25.73 | 22369663 | |
| 383 | Ubiquitination | REMLQQNKIMKVIRK HHHHHHCHHHHHHHH | 39.58 | 23749301 | |
| 386 | Ubiquitination | LQQNKIMKVIRKNIV HHHCHHHHHHHHHHH | 37.67 | 22817900 | |
| 394 | Ubiquitination | VIRKNIVKKLIEAFN HHHHHHHHHHHHHHH | 37.76 | 17644757 | |
| 395 | Acetylation | IRKNIVKKLIEAFNE HHHHHHHHHHHHHHH | 43.75 | - | |
| 395 | Ubiquitination | IRKNIVKKLIEAFNE HHHHHHHHHHHHHHH | 43.75 | 17644757 | |
| 412 | Ubiquitination | EDSEQFDKFYSAFAK CCHHHHHHHHHHHHH | 47.71 | 23749301 | |
| 415 | Phosphorylation | EQFDKFYSAFAKNIK HHHHHHHHHHHHHCC | 21.75 | 21440633 | |
| 419 | Acetylation | KFYSAFAKNIKLGVH HHHHHHHHHCCCCCC | 53.40 | 24489116 | |
| 419 | Ubiquitination | KFYSAFAKNIKLGVH HHHHHHHHHCCCCCC | 53.40 | 22817900 | |
| 422 | Ubiquitination | SAFAKNIKLGVHEDT HHHHHHCCCCCCHHH | 48.89 | 23749301 | |
| 429 | Phosphorylation | KLGVHEDTQNRAALA CCCCCHHHHCHHHHH | 25.43 | 20377248 | |
| 437 | Ubiquitination | QNRAALAKLLRYNST HCHHHHHHHHHHCCC | 49.24 | 23749301 | |
| 441 | Phosphorylation | ALAKLLRYNSTKSVD HHHHHHHHCCCCCHH | 17.27 | 21440633 | |
| 443 | Phosphorylation | AKLLRYNSTKSVDEL HHHHHHCCCCCHHHH | 28.42 | 21440633 | |
| 444 | Phosphorylation | KLLRYNSTKSVDELT HHHHHCCCCCHHHHH | 24.57 | 21440633 | |
| 445 | Ubiquitination | LLRYNSTKSVDELTS HHHHCCCCCHHHHHH | 48.58 | 23749301 | |
| 446 | Phosphorylation | LRYNSTKSVDELTSL HHHCCCCCHHHHHHH | 34.58 | 22369663 | |
| 451 | Phosphorylation | TKSVDELTSLTDYVT CCCHHHHHHHHHHHH | 21.46 | 19779198 | |
| 452 | Phosphorylation | KSVDELTSLTDYVTR CCHHHHHHHHHHHHH | 41.73 | 25752575 | |
| 454 | Phosphorylation | VDELTSLTDYVTRMP HHHHHHHHHHHHHCC | 25.67 | 19779198 | |
| 458 | Phosphorylation | TSLTDYVTRMPEHQK HHHHHHHHHCCHHHC | 18.28 | 19779198 | |
| 465 | Ubiquitination | TRMPEHQKNIYYITG HHCCHHHCCEEEECC | 47.42 | 24961812 | |
| 468 | Phosphorylation | PEHQKNIYYITGESL CHHHCCEEEECCHHH | 9.75 | 22369663 | |
| 469 | Phosphorylation | EHQKNIYYITGESLK HHHCCEEEECCHHHH | 6.55 | 22369663 | |
| 471 | Phosphorylation | QKNIYYITGESLKAV HCCEEEECCHHHHHH | 20.83 | 22369663 | |
| 474 | Phosphorylation | IYYITGESLKAVEKS EEEECCHHHHHHHHC | 36.19 | 22369663 | |
| 476 | Ubiquitination | YITGESLKAVEKSPF EECCHHHHHHHHCCH | 60.71 | 24961812 | |
| 480 | Ubiquitination | ESLKAVEKSPFLDAL HHHHHHHHCCHHHHH | 57.75 | 23749301 | |
| 481 | Phosphorylation | SLKAVEKSPFLDALK HHHHHHHCCHHHHHH | 13.84 | 21440633 | |
| 488 | Ubiquitination | SPFLDALKAKNFEVL CCHHHHHHHCCCEEE | 60.06 | 23749301 | |
| 490 | Ubiquitination | FLDALKAKNFEVLFL HHHHHHHCCCEEEEE | 61.66 | 22817900 | |
| 510 | Ubiquitination | EYAFTQLKEFEGKTL HHHHHHHHHCCCCEE | 51.01 | 17644757 | |
| 515 | Ubiquitination | QLKEFEGKTLVDITK HHHHCCCCEEEEHHH | 31.33 | 23749301 | |
| 529 | Phosphorylation | KDFELEETDEEKAER HCCCCCCCHHHHHHH | 39.06 | 27214570 | |
| 533 | Ubiquitination | LEETDEEKAEREKEI CCCCHHHHHHHHHHH | 54.20 | 24961812 | |
| 538 | Ubiquitination | EEKAEREKEIKEYEP HHHHHHHHHHHHHHH | 71.59 | 24961812 | |
| 541 | Ubiquitination | AEREKEIKEYEPLTK HHHHHHHHHHHHHHH | 56.16 | 23749301 | |
| 543 | Phosphorylation | REKEIKEYEPLTKAL HHHHHHHHHHHHHHH | 20.18 | 28889911 | |
| 547 | Phosphorylation | IKEYEPLTKALKDIL HHHHHHHHHHHHHHH | 25.61 | 28889911 | |
| 548 | Ubiquitination | KEYEPLTKALKDILG HHHHHHHHHHHHHHC | 60.45 | 23749301 | |
| 551 | Acetylation | EPLTKALKDILGDQV HHHHHHHHHHHCCCC | 47.81 | 24489116 | |
| 551 | Succinylation | EPLTKALKDILGDQV HHHHHHHHHHHCCCC | 47.81 | 23954790 | |
| 551 | Ubiquitination | EPLTKALKDILGDQV HHHHHHHHHHHCCCC | 47.81 | 15699485 | |
| 560 | Acetylation | ILGDQVEKVVVSYKL HHCCCCEEEEEEEEE | 41.28 | - | |
| 560 | Ubiquitination | ILGDQVEKVVVSYKL HHCCCCEEEEEEEEE | 41.28 | 15699485 | |
| 565 | Phosphorylation | VEKVVVSYKLLDAPA CEEEEEEEEECCCCC | 8.27 | 21440633 | |
| 566 | Ubiquitination | EKVVVSYKLLDAPAA EEEEEEEEECCCCCH | 34.76 | 23749301 | |
| 576 | Phosphorylation | DAPAAIRTGQFGWSA CCCCHHHCCCCCCCC | 29.26 | 28889911 | |
| 582 | Phosphorylation | RTGQFGWSANMERIM HCCCCCCCCCHHHHH | 15.33 | 22369663 | |
| 590 | Ubiquitination | ANMERIMKAQALRDS CCHHHHHHHHHHHHC | 34.67 | 23749301 | |
| 597 | Phosphorylation | KAQALRDSSMSSYMS HHHHHHHCHHHHHHH | 22.85 | 20377248 | |
| 598 | Phosphorylation | AQALRDSSMSSYMSS HHHHHHCHHHHHHHC | 27.29 | 22369663 | |
| 600 | Phosphorylation | ALRDSSMSSYMSSKK HHHHCHHHHHHHCCC | 21.92 | 20377248 | |
| 601 | Phosphorylation | LRDSSMSSYMSSKKT HHHCHHHHHHHCCCE | 19.06 | 22369663 | |
| 602 | Phosphorylation | RDSSMSSYMSSKKTF HHCHHHHHHHCCCEE | 8.16 | 22369663 | |
| 604 | Phosphorylation | SSMSSYMSSKKTFEI CHHHHHHHCCCEEEC | 30.67 | 22369663 | |
| 605 | Phosphorylation | SMSSYMSSKKTFEIS HHHHHHHCCCEEECC | 22.95 | 21551504 | |
| 606 | Ubiquitination | MSSYMSSKKTFEISP HHHHHHCCCEEECCC | 48.83 | 23749301 | |
| 607 | Ubiquitination | SSYMSSKKTFEISPK HHHHHCCCEEECCCC | 61.47 | 23749301 | |
| 608 | Phosphorylation | SYMSSKKTFEISPKS HHHHCCCEEECCCCC | 30.18 | 19823750 | |
| 612 | Phosphorylation | SKKTFEISPKSPIIK CCCEEECCCCCHHHH | 21.05 | 22369663 | |
| 614 | Ubiquitination | KTFEISPKSPIIKEL CEEECCCCCHHHHHH | 63.17 | 23749301 | |
| 615 | Phosphorylation | TFEISPKSPIIKELK EEECCCCCHHHHHHH | 25.39 | 22369663 | |
| 619 | Ubiquitination | SPKSPIIKELKKRVD CCCCHHHHHHHHHHH | 58.68 | 23749301 | |
| 622 | Ubiquitination | SPIIKELKKRVDEGG CHHHHHHHHHHHCCC | 39.36 | 22817900 | |
| 623 | Ubiquitination | PIIKELKKRVDEGGA HHHHHHHHHHHCCCC | 70.99 | 22817900 | |
| 633 | Ubiquitination | DEGGAQDKTVKDLTN HCCCCCCCHHHHHHH | 43.04 | 23749301 | |
| 636 | Ubiquitination | GAQDKTVKDLTNLLF CCCCCHHHHHHHHHH | 52.86 | 22817900 | |
| 653 | Phosphorylation | ALLTSGFSLEEPTSF HHHHCCCCCCCCCCH | 38.09 | 28889911 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of HSC82_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of HSC82_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of HSC82_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-36; SER-51; SER-278;THR-281; SER-293; SER-330; SER-375; SER-446; SER-452; THR-471;SER-474; THR-529; SER-597; SER-598; TYR-602; SER-615 AND SER-653, ANDMASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-330 AND SER-615, ANDMASS SPECTROMETRY. | |
| "Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-597; SER-598 ANDSER-600, AND MASS SPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-615, AND MASSSPECTROMETRY. | |
