IDHH_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IDHH_YEAST
• UniProt AC: P53982
• Protein Name: Isocitrate dehydrogenase [NADP]
• Gene Name: IDP3
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 420
• Protein Description: May function in the production of NADPH for fatty acid and sterol synthesis..
• Protein Sequence: MSKIKVVHPIVEMDGDEQTRVIWKLIKEKLILPYLDVDLKYYDLSIQERDRTNDQVTKDSSYATLKYGVAVKCATITPDEARMKEFNLKEMWKSPNGTIRNILGGTVFREPIIIPKIPRLVPHWEKPIIIGRHAFGDQYRATDIKIKKAGKLRLQFSSDDGKENIDLKVYEFPKSGGIAMAMFNTNDSIKGFAKASFELALKRKLPLFFTTKNTILKNYDNQFKQIFDNLFDKEYKEKFQALKITYEHRLIDDMVAQMLKSKGGFIIAMKNYDGDVQSDIVAQGFGSLGLMTSILITPDGKTFESEAAHGTVTRHFRKHQRGEETSTNSIASIFAWTRAIIQRGKLDNTDDVIKFGNLLEKATLDTVQVGGKMTKDLALMLGKTNRSSYVTTEEFIDEVAKRLQNMMLSSNEDKKGMCKL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
77	Phosphorylation	AVKCATITPDEARMK EEEEEEECCCHHHHH	21.97	27214570
93	Acetylation	FNLKEMWKSPNGTIR CCHHHHHCCCCCCCC	55.51	25381059
126	Acetylation	RLVPHWEKPIIIGRH CCCCCCCCCEEEECC	36.00	25381059
126	Ubiquitination	RLVPHWEKPIIIGRH CCCCCCCCCEEEECC	36.00	24961812

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IDHH_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IDHH_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IDHH_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IDHC_YEAST	IDP2	genetic	18408719
PFKA1_YEAST	PFK1	genetic	21623372
DCOR_YEAST	SPE1	genetic	21623372
ATPA_YEAST	ATP1	genetic	21623372
GPP2_YEAST	GPP2	genetic	21623372
FOLE_YEAST	MET7	genetic	21623372
MED10_YEAST	NUT2	genetic	27708008
BFA1_YEAST	BFA1	genetic	27708008
POM33_YEAST	POM33	genetic	27708008
RS3A2_YEAST	RPS1B	genetic	27708008
IPA3_YEAST	PAI3	genetic	27708008
NEW1_YEAST	NEW1	genetic	27708008
CDC24_YEAST	CDC24	genetic	27708008
ORC2_YEAST	ORC2	genetic	27708008
RIB7_YEAST	RIB7	genetic	27708008
RPAB1_YEAST	RPB5	genetic	27708008
TCPD_YEAST	CCT4	genetic	27708008
GLE1_YEAST	GLE1	genetic	27708008
LCB2_YEAST	LCB2	genetic	27708008
GPI11_YEAST	GPI11	genetic	27708008
CCA1_YEAST	CCA1	genetic	27708008
CDC20_YEAST	CDC20	genetic	27708008
MCE1_YEAST	CEG1	genetic	27708008
SNU71_YEAST	SNU71	genetic	27708008
RPN1_YEAST	RPN1	genetic	27708008
MET30_YEAST	MET30	genetic	27708008
MED14_YEAST	RGR1	genetic	27708008
PRP39_YEAST	PRP39	genetic	27708008
TEM1_YEAST	TEM1	genetic	27708008
RNT1_YEAST	RNT1	genetic	27708008
IPL1_YEAST	IPL1	genetic	27708008
ARP7_YEAST	ARP7	genetic	27708008
PSB5_YEAST	PRE2	genetic	27708008
NTH1_YEAST	NTG1	genetic	27708008
KCC4_YEAST	KCC4	genetic	27708008
MED5_YEAST	NUT1	genetic	27708008
OPI1_YEAST	OPI1	genetic	27708008
GGA2_YEAST	GGA2	genetic	27708008
VPS53_YEAST	VPS53	genetic	27708008
HMX1_YEAST	HMX1	genetic	27708008
U5071_YEAST	YML003W	genetic	27708008
SFL1_YEAST	SFL1	genetic	27708008
HAT1_YEAST	HAT1	genetic	27708008
CRC1_YEAST	CRC1	genetic	27453043
IMDH4_YEAST	IMD4	genetic	27453043
AAKG_YEAST	SNF4	genetic	27453043
PALA_YEAST	RIM20	genetic	27453043
AAP1_YEAST	AAP1	genetic	27453043
SYFM_YEAST	MSF1	genetic	27453043
BRE1_YEAST	BRE1	genetic	27453043
DIC1_YEAST	DIC1	genetic	27453043
CYPD_YEAST	CPR5	genetic	27453043
DCAM_YEAST	SPE2	genetic	27453043
SWI4_YEAST	SWI4	genetic	27453043
DCOR_YEAST	SPE1	genetic	27453043

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.