| UniProt ID | CDC24_YEAST | |
|---|---|---|
| UniProt AC | P11433 | |
| Protein Name | Cell division control protein 24 | |
| Gene Name | CDC24 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 854 | |
| Subcellular Localization | ||
| Protein Description | Promotes the exchange of CDC42-bound GDP by GTP. Controls the polarity of calmodulin, and the calcium regulatory process of bud emergence. CDC24 may be involved in the initial selection and organization of the budding site.. | |
| Protein Sequence | MAIQTRFASGTSLSDLKPKPSATSISIPMQNVMNKPVTEQDSLFHICANIRKRLEVLPQLKPFLQLAYQSSEVLSERQSLLLSQKQHQELLKSNGANRDSSDLAPTLRSSSISTATSLMSMEGISYTNSNPSATPNMEDTLLTFSMGILPITMDCDPVTQLSQLFQQGAPLCILFNSVKPQFKLPVIASDDLKVCKKSIYDFILGCKKHFAFNDEELFTISDVFANSTSQLVKVLEVVETLMNSSPTIFPSKSKTQQIMNAENQHRHQPQQSSKKHNEYVKIIKEFVATERKYVHDLEILDKYRQQLLDSNLITSEELYMLFPNLGDAIDFQRRFLISLEINALVEPSKQRIGALFMHSKHFFKLYEPWSIGQNAAIEFLSSTLHKMRVDESQRFIINNKLELQSFLYKPVQRLCRYPLLVKELLAESSDDNNTKELEAALDISKNIARSINENQRRTENHQVVKKLYGRVVNWKGYRISKFGELLYFDKVFISTTNSSSEPEREFEVYLFEKIIILFSEVVTKKSASSLILKKKSSTSASISASNITDNNGSPHHSYHKRHSNSSSSNNIHLSSSSAAAIIHSSTNSSDNNSNNSSSSSLFKLSANEPKLDLRGRIMIMNLNQIIPQNNRSLNITWESIKEQGNFLLKFKNEETRDNWSSCLQQLIHDLKNEQFKARHHSSTSTTSSTAKSSSMMSPTTTMNTPNHHNSRQTHDSMASFSSSHMKRVSDVLPKRRTTSSSFESEIKSISENFKNSIPESSILFRISYNNNSNNTSSSEIFTLLVEKVWNFDDLIMAINSKISNTHNNNISPITKIKYQDEDGDFVVLGSDEDWNVAKEMLAENNEKFLNIRLY | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 5 | Phosphorylation | ---MAIQTRFASGTS ---CCCEEECCCCCC | 22.95 | 24961812 | |
| 9 | Phosphorylation | AIQTRFASGTSLSDL CCEEECCCCCCHHHC | 39.63 | 19823750 | |
| 11 | Phosphorylation | QTRFASGTSLSDLKP EEECCCCCCHHHCCC | 24.81 | 19823750 | |
| 12 | Phosphorylation | TRFASGTSLSDLKPK EECCCCCCHHHCCCC | 29.42 | 19823750 | |
| 14 | Phosphorylation | FASGTSLSDLKPKPS CCCCCCHHHCCCCCC | 40.44 | 19823750 | |
| 93 | Phosphorylation | QHQELLKSNGANRDS HHHHHHHHCCCCCCH | 40.23 | 30377154 | |
| 100 | Phosphorylation | SNGANRDSSDLAPTL HCCCCCCHHHCHHHH | 23.63 | 22369663 | |
| 101 | Phosphorylation | NGANRDSSDLAPTLR CCCCCCHHHCHHHHH | 40.72 | 22369663 | |
| 106 | Phosphorylation | DSSDLAPTLRSSSIS CHHHCHHHHHHCCCH | 29.24 | 28889911 | |
| 392 | Phosphorylation | HKMRVDESQRFIINN HHCCCCHHHHEEECC | 23.38 | 30377154 | |
| 409 | Acetylation | ELQSFLYKPVQRLCR HHHHHHHHHHHHHCC | 40.64 | 24489116 | |
| 481 | Acetylation | WKGYRISKFGELLYF CCCEEECCCCCEEEE | 55.83 | 24489116 | |
| 526 | Phosphorylation | SEVVTKKSASSLILK HHHHCCCCHHHHEEE | 34.63 | 22369663 | |
| 528 | Phosphorylation | VVTKKSASSLILKKK HHCCCCHHHHEEEEC | 32.54 | 22369663 | |
| 529 | Phosphorylation | VTKKSASSLILKKKS HCCCCHHHHEEEECC | 21.10 | 22369663 | |
| 539 | Phosphorylation | LKKKSSTSASISASN EEECCCCCCEEECCC | 23.20 | 19668330 | |
| 553 | Phosphorylation | NITDNNGSPHHSYHK CCCCCCCCCCCCCCC | 24.16 | 21440633 | |
| 557 | Phosphorylation | NNGSPHHSYHKRHSN CCCCCCCCCCCCCCC | 26.37 | 28889911 | |
| 558 | Phosphorylation | NGSPHHSYHKRHSNS CCCCCCCCCCCCCCC | 13.65 | 19668330 | |
| 563 | Phosphorylation | HSYHKRHSNSSSSNN CCCCCCCCCCCCCCC | 42.30 | 28889911 | |
| 565 | Phosphorylation | YHKRHSNSSSSNNIH CCCCCCCCCCCCCEE | 34.31 | 28889911 | |
| 566 | Phosphorylation | HKRHSNSSSSNNIHL CCCCCCCCCCCCEEE | 41.87 | 28889911 | |
| 567 | Phosphorylation | KRHSNSSSSNNIHLS CCCCCCCCCCCEEEC | 36.59 | 28889911 | |
| 568 | Phosphorylation | RHSNSSSSNNIHLSS CCCCCCCCCCEEECC | 35.52 | 28889911 | |
| 574 | Phosphorylation | SSNNIHLSSSSAAAI CCCCEEECCCCEEHH | 17.63 | 24961812 | |
| 575 | Phosphorylation | SNNIHLSSSSAAAII CCCEEECCCCEEHHH | 34.37 | 24961812 | |
| 576 | Phosphorylation | NNIHLSSSSAAAIIH CCEEECCCCEEHHHH | 22.18 | 24961812 | |
| 577 | Phosphorylation | NIHLSSSSAAAIIHS CEEECCCCEEHHHHC | 24.71 | 24961812 | |
| 584 | Phosphorylation | SAAAIIHSSTNSSDN CEEHHHHCCCCCCCC | 28.57 | 24961812 | |
| 585 | Phosphorylation | AAAIIHSSTNSSDNN EEHHHHCCCCCCCCC | 19.90 | 24961812 | |
| 586 | Phosphorylation | AAIIHSSTNSSDNNS EHHHHCCCCCCCCCC | 41.98 | 24961812 | |
| 588 | Phosphorylation | IIHSSTNSSDNNSNN HHHCCCCCCCCCCCC | 38.87 | 24961812 | |
| 589 | Phosphorylation | IHSSTNSSDNNSNNS HHCCCCCCCCCCCCC | 46.56 | 24961812 | |
| 593 | Phosphorylation | TNSSDNNSNNSSSSS CCCCCCCCCCCCCCH | 43.58 | 24961812 | |
| 596 | Phosphorylation | SDNNSNNSSSSSLFK CCCCCCCCCCCHHHH | 35.53 | 28889911 | |
| 597 | Phosphorylation | DNNSNNSSSSSLFKL CCCCCCCCCCHHHHH | 36.04 | 28889911 | |
| 598 | Phosphorylation | NNSNNSSSSSLFKLS CCCCCCCCCHHHHHC | 24.62 | 28889911 | |
| 599 | Phosphorylation | NSNNSSSSSLFKLSA CCCCCCCCHHHHHCC | 32.77 | 28889911 | |
| 600 | Phosphorylation | SNNSSSSSLFKLSAN CCCCCCCHHHHHCCC | 39.51 | 28889911 | |
| 641 | Ubiquitination | NITWESIKEQGNFLL CEEHHHHHHHCCEEE | 53.95 | 17644757 | |
| 649 | Ubiquitination | EQGNFLLKFKNEETR HHCCEEEEECCHHHC | 57.34 | 17644757 | |
| 649 | Acetylation | EQGNFLLKFKNEETR HHCCEEEEECCHHHC | 57.34 | 24489116 | |
| 681 | Phosphorylation | QFKARHHSSTSTTSS HHHHHCCCCCCCCCC | 29.23 | 27717283 | |
| 682 | Phosphorylation | FKARHHSSTSTTSST HHHHCCCCCCCCCCC | 23.24 | 27717283 | |
| 683 | Phosphorylation | KARHHSSTSTTSSTA HHHCCCCCCCCCCCC | 32.86 | 27717283 | |
| 684 | Phosphorylation | ARHHSSTSTTSSTAK HHCCCCCCCCCCCCC | 31.47 | 27717283 | |
| 685 | Phosphorylation | RHHSSTSTTSSTAKS HCCCCCCCCCCCCCC | 30.68 | 27717283 | |
| 686 | Phosphorylation | HHSSTSTTSSTAKSS CCCCCCCCCCCCCCC | 22.05 | 27717283 | |
| 687 | Phosphorylation | HSSTSTTSSTAKSSS CCCCCCCCCCCCCCC | 26.27 | 27717283 | |
| 688 | Phosphorylation | SSTSTTSSTAKSSSM CCCCCCCCCCCCCCC | 30.23 | 28889911 | |
| 689 | Phosphorylation | STSTTSSTAKSSSMM CCCCCCCCCCCCCCC | 37.56 | 28889911 | |
| 692 | Phosphorylation | TTSSTAKSSSMMSPT CCCCCCCCCCCCCCC | 25.77 | 28889911 | |
| 693 | Phosphorylation | TSSTAKSSSMMSPTT CCCCCCCCCCCCCCC | 22.88 | 28889911 | |
| 694 | Phosphorylation | SSTAKSSSMMSPTTT CCCCCCCCCCCCCCC | 26.12 | 28889911 | |
| 697 | Phosphorylation | AKSSSMMSPTTTMNT CCCCCCCCCCCCCCC | 15.51 | 19782078 | |
| 699 | Phosphorylation | SSSMMSPTTTMNTPN CCCCCCCCCCCCCCC | 27.82 | 28889911 | |
| 700 | Phosphorylation | SSMMSPTTTMNTPNH CCCCCCCCCCCCCCC | 27.68 | 28889911 | |
| 701 | Phosphorylation | SMMSPTTTMNTPNHH CCCCCCCCCCCCCCC | 15.76 | 28889911 | |
| 704 | Phosphorylation | SPTTTMNTPNHHNSR CCCCCCCCCCCCCCC | 18.04 | 19782078 | |
| 719 | Phosphorylation | QTHDSMASFSSSHMK CCCHHHHHHCHHHHH | 19.61 | 21551504 | |
| 721 | Phosphorylation | HDSMASFSSSHMKRV CHHHHHHCHHHHHHH | 28.56 | 27017623 | |
| 722 | Phosphorylation | DSMASFSSSHMKRVS HHHHHHCHHHHHHHH | 23.42 | 30377154 | |
| 723 | Phosphorylation | SMASFSSSHMKRVSD HHHHHCHHHHHHHHH | 26.80 | 27017623 | |
| 729 | Phosphorylation | SSHMKRVSDVLPKRR HHHHHHHHHHCCCCC | 26.49 | 19823750 | |
| 737 | Phosphorylation | DVLPKRRTTSSSFES HHCCCCCCCCHHHHH | 34.75 | 25521595 | |
| 738 | Phosphorylation | VLPKRRTTSSSFESE HCCCCCCCCHHHHHH | 25.46 | 19823750 | |
| 739 | Phosphorylation | LPKRRTTSSSFESEI CCCCCCCCHHHHHHH | 24.30 | 22369663 | |
| 740 | Phosphorylation | PKRRTTSSSFESEIK CCCCCCCHHHHHHHH | 36.63 | 25521595 | |
| 741 | Phosphorylation | KRRTTSSSFESEIKS CCCCCCHHHHHHHHH | 32.57 | 22369663 | |
| 744 | Phosphorylation | TTSSSFESEIKSISE CCCHHHHHHHHHHHH | 42.48 | 22890988 | |
| 748 | Phosphorylation | SFESEIKSISENFKN HHHHHHHHHHHHHHH | 36.69 | 23749301 | |
| 750 | Phosphorylation | ESEIKSISENFKNSI HHHHHHHHHHHHHCC | 33.31 | 24909858 | |
| 756 | Phosphorylation | ISENFKNSIPESSIL HHHHHHHCCCCCCEE | 39.86 | 19668330 | |
| 801 | Ubiquitination | LIMAINSKISNTHNN HHHHHHHHHCCCCCC | 45.74 | 17644757 | |
| 803 | Phosphorylation | MAINSKISNTHNNNI HHHHHHHCCCCCCCC | 39.14 | 23749301 | |
| 805 | Phosphorylation | INSKISNTHNNNISP HHHHHCCCCCCCCCC | 21.13 | 23749301 | |
| 811 | Phosphorylation | NTHNNNISPITKIKY CCCCCCCCCCEEEEE | 16.63 | 28889911 | |
| 815 | Ubiquitination | NNISPITKIKYQDED CCCCCCEEEEEECCC | 37.61 | 17644757 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CDC24_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CDC24_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CDC24_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9; SER-100; SER-729;THR-738; SER-740; SER-741 AND SER-803, AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-100; SER-101; SER-729;THR-738 AND SER-741, AND MASS SPECTROMETRY. | |
| "Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-738, AND MASSSPECTROMETRY. | |
