EKI1_YEAST - dbPTM
EKI1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID EKI1_YEAST
UniProt AC Q03764
Protein Name Ethanolamine kinase
Gene Name EKI1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 534
Subcellular Localization
Protein Description Catalyzes the committed step of phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway. Also exhibits choline kinase activity but its preferred substrate is ethanolamine..
Protein Sequence MYTNYSLTSSDAMPRTYLVGTASPEMSKKKRQSANCDKPTRRVIHIIDTNEHSEVDLKNELPITCTNEDGEMTSSSWTSQTANDFLKLAYVNAKLDPSLPSQYFKQDIINVLQSLEIPGWSVPGSKESSLNKNLLTLTQIKGALTNVIYKIHYPNLPPLLMRIFGDSIDSVIDREYELKVIARLSFYDLGPKLEGFFENGRFEKYIEGSRTSTQADFIDRDTSIKIAKKLKELHCTVPLTHKEITDQPSCWTTFDQWIKLIDSHKEWVSNNVNISENLRCSSWNFFLKSFKNYKRWLYNDSAFTSKLLREDDKDSMINSGLKMVFCHNDLQHGNLLFKSKGKDDISVGDLTIIDFEYAGPNPVVFDLSNHLNEWMQDYNDVQSFKSHIDKYPKEEDILVFAQSYINHMNENHVKIASQEVRILYNLIIEWRPCTQLFWCLWALLQSGRLPQRPLIEGEKLMSEKAGLGDETHLMEHKNKENGKYDCSEDDSFNYLGFCKEKMSVFWGDLITLGVIDKDCPDIGKTDYLDTKLIF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MYTNYSLTS
------CCCCCCCCC		12.0523607784
3Phosphorylation-----MYTNYSLTSS
-----CCCCCCCCCC		26.7823607784
5Phosphorylation---MYTNYSLTSSDA
---CCCCCCCCCCCC		9.3923607784
6Phosphorylation--MYTNYSLTSSDAM
--CCCCCCCCCCCCC		27.5223607784
8PhosphorylationMYTNYSLTSSDAMPR
CCCCCCCCCCCCCCC		21.9023607784
9PhosphorylationYTNYSLTSSDAMPRT
CCCCCCCCCCCCCCE		31.3623607784
10PhosphorylationTNYSLTSSDAMPRTY
CCCCCCCCCCCCCEE		24.9323607784
16PhosphorylationSSDAMPRTYLVGTAS
CCCCCCCEEEEECCC		18.4823607784
17PhosphorylationSDAMPRTYLVGTASP
CCCCCCEEEEECCCH		10.7323607784
21PhosphorylationPRTYLVGTASPEMSK
CCEEEEECCCHHHHH		19.2421440633
23PhosphorylationTYLVGTASPEMSKKK
EEEEECCCHHHHHHH		22.6421082442
27PhosphorylationGTASPEMSKKKRQSA
ECCCHHHHHHHHHHC		39.3923607784
132AcetylationSKESSLNKNLLTLTQ
CCHHHCCCCHHHHHH		55.0224489116
301PhosphorylationKRWLYNDSAFTSKLL
HHHHHCCCHHHHHHC		22.9628889911
313AcetylationKLLREDDKDSMINSG
HHCCCCCHHHCHHHC		65.1124489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of EKI1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of EKI1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of EKI1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SDO1L_YEASTRTC3physical
16554755
SSB1_YEASTSSB1physical
19536198
PRP6_YEASTPRP6genetic
27708008
FNTA_YEASTRAM2genetic
27708008
TDA5_YEASTTDA5genetic
27708008
ATP18_YEASTATP18genetic
27708008
GBLP_YEASTASC1genetic
27708008
UBP8_YEASTUBP8genetic
27708008
ATG3_YEASTATG3genetic
27708008
PHO80_YEASTPHO80genetic
27708008
MDM38_YEASTMDM38genetic
27708008
RTG1_YEASTRTG1genetic
27708008
SDHF2_YEASTSDH5genetic
27708008
YAP4_YEASTCIN5genetic
27708008
ORC2_YEASTORC2genetic
27708008
SNU23_YEASTSNU23genetic
27708008
GLE1_YEASTGLE1genetic
27708008
TBP_YEASTSPT15genetic
27708008
COG3_YEASTCOG3genetic
27708008
GNA1_YEASTGNA1genetic
27708008
MOB2_YEASTMOB2genetic
27708008
DPOD2_YEASTPOL31genetic
27708008
SED5_YEASTSED5genetic
27708008
SEC22_YEASTSEC22genetic
27708008
NSE5_YEASTNSE5genetic
27708008
VTI1_YEASTVTI1genetic
27708008
BUR1_YEASTSGV1genetic
27708008
DEP1_YEASTDEP1genetic
27708008
NTH1_YEASTNTG1genetic
27708008
NHP10_YEASTNHP10genetic
27708008
SLX5_YEASTSLX5genetic
27708008
BRE1_YEASTBRE1genetic
27708008
RL13A_YEASTRPL13Agenetic
27708008
IES1_YEASTIES1genetic
27708008
VMA21_YEASTVMA21genetic
27708008
TNA1_YEASTTNA1genetic
27708008
GOSR1_YEASTGOS1genetic
27708008
ACA2_YEASTCST6genetic
27708008
ALLA_YEASTDAL3genetic
27708008
RS21B_YEASTRPS21Bgenetic
27708008
ILM1_YEASTILM1genetic
27708008
LST4_YEASTLST4genetic
27708008
SAC1_YEASTSAC1genetic
27708008
YL032_YEASTYLL032Cgenetic
27708008
FRE8_YEASTFRE8genetic
27708008
RSSA2_YEASTRPS0Bgenetic
27708008
RL22A_YEASTRPL22Agenetic
27708008
NAH1_YEASTNHA1genetic
27708008
POC1_YEASTPBA1genetic
27708008
ENT2_YEASTENT2genetic
27708008
YL278_YEASTYLR278Cgenetic
27708008
CDC73_YEASTCDC73genetic
27708008
PSP2_YEASTPSP2genetic
27708008
YMC0_YEASTYML020Wgenetic
27708008
RS3A2_YEASTRPS1Bgenetic
27708008
PLB1_YEASTPLB1genetic
27708008
HXT2_YEASTHXT2genetic
27708008
FAR8_YEASTFAR8genetic
27708008
YET2_YEASTYET2genetic
27708008
FAR3_YEASTFAR3genetic
27708008
YM04_YEASTYMR114Cgenetic
27708008
NUP53_YEASTNUP53genetic
27708008
SPG5_YEASTSPG5genetic
27708008
ZRC1_YEASTZRC1genetic
27708008
CAT8_YEASTCAT8genetic
27708008
FAR11_YEASTFAR11genetic
27708008
DUS2_YEASTSMM1genetic
27708008
SIN3_YEASTSIN3genetic
27708008
ALG6_YEASTALG6genetic
27708008
CRS5_YEASTCRS5genetic
27708008
CSK2C_YEASTCKB2genetic
27708008
IRC23_YEASTIRC23genetic
27708008
ALG8_YEASTALG8genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of EKI1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-23 AND SER-301, AND MASSSPECTROMETRY.

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