LST4_YEAST - dbPTM
LST4_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LST4_YEAST
UniProt AC P34239
Protein Name Protein LST4
Gene Name LST4
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 828
Subcellular Localization
Protein Description Involved in extracellular amino acid uptake. Required for the trafficking of the GAP1 nitrogen-regulated general amino acid permease from the Golgi to the plasma membrane..
Protein Sequence MLGNLLRNKTSSSGFEKSSEHSDFSSVVPNVPVYCKAASTGTTKTAAGALLDTAVNVEKPSEMLSTTSPPILDHISDDLKLKLFGSRDIPYSRPIDTLQNNGGLGTDKITSINEKTYAFRILIIEEAGQMACRNNYRDIFDYTTSKISNSMEQIRPSELKEYIFGSPVRSSDLTQCDKIRTIPNSDLVLITRIFYYTHQYNRIAISLCIPRILLPVVAESWSSISSWLTQTQKMLIGFLTKNRIMQENTGNYSNNSVIKLSNIDIRTHYPKEIEIMVQTLQKRVIPGLRSMSEIPRLFLYPETFKEFVHVWFKSIFNWIEIKDGPKLGFLPLLMAMIISDYRHTIRELKTSKIVILSGNMVVANKLLFILSALLEPKYKGQITIRRENIRSDSSAVSRNKSNNNFVDKPETELSTLTSTDNLLSRTENNSNHNYNNSNVSSNSIGSPNFHSLRKGWQIPNRRNSNTSVSVSSSESLAEVIQPSSFKSGSSSLHYLSSSISSQPGSYGSWFNKRPTISQFFQPSPSLKHNESWERLQTTAGNMQRTSSSSSLQQATSRLSLTTPQQSPSISEYDEYPWMGTPGSPNVGDVSHAPPLVKNISYKFPLKNVELKRDCQRISQDDLLDEAFERICQPSLADLNSTYEIFPGNSSYADILTTDSDIDDGLMNKPLELLPKYTMYLTHFNNFFQLQACPAGQESESRITNSMKIDLLKADYTRSLLVSLRSRDIRDVALKREFTGNNNNNSNQNIYDENFVGKRKYVLKQKTRKIFSCGKIGKLSTSLENCVNFVENSIKSAMMLYDDNGIDSELRDSEALRIFSSLVHYCNAG
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
11PhosphorylationNLLRNKTSSSGFEKS
HHHCCCCCCCCCCCC		24.9023749301
91PhosphorylationFGSRDIPYSRPIDTL
CCCCCCCCCCCCCCC		20.0421440633
92PhosphorylationGSRDIPYSRPIDTLQ
CCCCCCCCCCCCCCC		26.6529688323
97PhosphorylationPYSRPIDTLQNNGGL
CCCCCCCCCCCCCCC		30.8529688323
106PhosphorylationQNNGGLGTDKITSIN
CCCCCCCCCCCCCCC		38.8821440633
111PhosphorylationLGTDKITSINEKTYA
CCCCCCCCCCCCCCE		27.2227214570
393PhosphorylationRENIRSDSSAVSRNK
ECHHCCCCCCCCCCC		22.8027214570
397PhosphorylationRSDSSAVSRNKSNNN
CCCCCCCCCCCCCCC		29.8327214570
401PhosphorylationSAVSRNKSNNNFVDK
CCCCCCCCCCCCCCC		48.6222369663
411PhosphorylationNFVDKPETELSTLTS
CCCCCCHHHHHHHHC		51.2422369663
414PhosphorylationDKPETELSTLTSTDN
CCCHHHHHHHHCHHH		18.3522369663
415PhosphorylationKPETELSTLTSTDNL
CCHHHHHHHHCHHHH		46.8322369663
417PhosphorylationETELSTLTSTDNLLS
HHHHHHHHCHHHHHH		29.6623749301
418PhosphorylationTELSTLTSTDNLLSR
HHHHHHHCHHHHHHC		36.5522369663
419PhosphorylationELSTLTSTDNLLSRT
HHHHHHCHHHHHHCC		24.5422369663
424PhosphorylationTSTDNLLSRTENNSN
HCHHHHHHCCCCCCC		40.0822369663
446PhosphorylationVSSNSIGSPNFHSLR
CCCCCCCCCCHHHHC		18.2623749301
498PhosphorylationSLHYLSSSISSQPGS
HHHHHHHCCCCCCCC		24.1021440633
501PhosphorylationYLSSSISSQPGSYGS
HHHHCCCCCCCCCCC		38.4321440633
505PhosphorylationSISSQPGSYGSWFNK
CCCCCCCCCCCCCCC		32.7624961812
506PhosphorylationISSQPGSYGSWFNKR
CCCCCCCCCCCCCCC		22.5424961812
508PhosphorylationSQPGSYGSWFNKRPT
CCCCCCCCCCCCCCC		21.9124961812
517PhosphorylationFNKRPTISQFFQPSP
CCCCCCHHHHCCCCC		24.3421440633
523PhosphorylationISQFFQPSPSLKHNE
HHHHCCCCCCCCCCH		19.1522369663
525PhosphorylationQFFQPSPSLKHNESW
HHCCCCCCCCCCHHH		55.1522369663
531PhosphorylationPSLKHNESWERLQTT
CCCCCCHHHHHHHHH		39.2830377154
537PhosphorylationESWERLQTTAGNMQR
HHHHHHHHHHHHHHC		24.1727017623
545PhosphorylationTAGNMQRTSSSSSLQ
HHHHHHCCCCCHHHH		18.9722369663
546PhosphorylationAGNMQRTSSSSSLQQ
HHHHHCCCCCHHHHH		30.3422369663
547PhosphorylationGNMQRTSSSSSLQQA
HHHHCCCCCHHHHHH		33.3622369663
548PhosphorylationNMQRTSSSSSLQQAT
HHHCCCCCHHHHHHH		24.5822369663
549PhosphorylationMQRTSSSSSLQQATS
HHCCCCCHHHHHHHH		36.7021440633
550PhosphorylationQRTSSSSSLQQATSR
HCCCCCHHHHHHHHH		31.9522369663
555PhosphorylationSSSLQQATSRLSLTT
CHHHHHHHHHHCCCC		15.2722369663
556PhosphorylationSSLQQATSRLSLTTP
HHHHHHHHHHCCCCC		33.9522369663
580PhosphorylationDEYPWMGTPGSPNVG
CCCCCCCCCCCCCCC		14.3619779198
583PhosphorylationPWMGTPGSPNVGDVS
CCCCCCCCCCCCCCC		17.9519779198
606SuccinylationISYKFPLKNVELKRD
EEEECCCCCCCCHHH		60.2223954790
698PhosphorylationACPAGQESESRITNS
ECCCCCCCHHHHCCC		32.7428889911
738PhosphorylationVALKREFTGNNNNNS
HHHHHEECCCCCCCC		33.9628889911
745PhosphorylationTGNNNNNSNQNIYDE
CCCCCCCCCCCCCCC		41.7522369663
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of LST4_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of LST4_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LST4_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SWD1_YEASTSWD1genetic
20093466
SEA4_YEASTSEA4genetic
20093466
BAP2_YEASTBAP2genetic
20093466
ARL1_YEASTARL1genetic
20093466
SWD3_YEASTSWD3genetic
20093466
CLPX_YEASTMCX1genetic
20093466
SNT1_YEASTSNT1genetic
20093466
THRC_YEASTTHR4genetic
20093466
PP2C1_YEASTPTC1genetic
20093466
NHP10_YEASTNHP10genetic
20093466
ARO1_YEASTARO1genetic
20093466
WDR59_YEASTMTC5genetic
20093466
DHAS_YEASTHOM2genetic
20093466
NBP2_YEASTNBP2genetic
20093466
IPK1_YEASTIPK1genetic
20093466
LSM6_YEASTLSM6genetic
20093466
STP1_YEASTSTP1genetic
20093466
AK_YEASTHOM3genetic
20093466
PUS3_YEASTDEG1genetic
20093466
ZRT1_YEASTZRT1genetic
20093466
RTF1_YEASTRTF1genetic
20093466
HOS2_YEASTHOS2genetic
20093466
MED5_YEASTNUT1genetic
20093466
AROC_YEASTARO2genetic
20093466
CWH41_YEASTCWH41genetic
20093466
PIB2_YEASTPIB2genetic
20093466
PUR4_YEASTADE6genetic
20093466
SERB_YEASTSER2genetic
20093466
NPR3_YEASTNPR3genetic
20093466
SLT2_YEASTSLT2genetic
20093466
STB5_YEASTSTB5genetic
20093466
LPLA_YEASTAIM22genetic
20093466
TOR1_YEASTTOR1genetic
20093466
DHOM_YEASTHOM6genetic
20093466
NFU1_YEASTNFU1genetic
20093466
BRE2_YEASTBRE2genetic
20093466
CHS5_YEASTCHS5genetic
20093466
ERG6_YEASTERG6genetic
20093466
GAS1_YEASTGAS1genetic
20093466
ADE_YEASTAAH1genetic
20093466
IDH1_YEASTIDH1genetic
20093466
MED9_YEASTCSE2genetic
20093466
NDJ1_YEASTNDJ1genetic
20093466
REXO4_YEASTREX4genetic
20093466
SERC_YEASTSER1genetic
20093466
NEW1_YEASTNEW1genetic
20093466
YP150_YEASTYPL150Wgenetic
20093466
ATG21_YEASTATG21genetic
20093466
LGE1_YEASTLGE1genetic
20093466
CHMU_YEASTARO7genetic
20093466
TKT1_YEASTTKL1genetic
20093466
MMS1_YEASTMMS1genetic
20093466
RSP5_YEASTRSP5genetic
11352928
PDC2_YEASTPDC2genetic
27708008
VAM6_YEASTVAM6genetic
27708008
SUR2_YEASTSUR2genetic
27708008
LSM6_YEASTLSM6genetic
27708008
XRN1_YEASTXRN1genetic
27708008
GTR2_YEASTGTR2genetic
27708008
NPR3_YEASTNPR3genetic
27708008
RPN5_YEASTRPN5genetic
27708008
RMRP_YEASTSNM1genetic
27708008
PSB3_YEASTPUP3genetic
27708008
CDC11_YEASTCDC11genetic
27708008
IMB1_YEASTKAP95genetic
27708008
TAF11_YEASTTAF11genetic
27708008
NAB3_YEASTNAB3genetic
27708008
SWD1_YEASTSWD1genetic
27708008
SEA4_YEASTSEA4genetic
27708008
NHP10_YEASTNHP10genetic
27708008
PP2C1_YEASTPTC1genetic
27708008
BRE1_YEASTBRE1genetic
27708008
ARO1_YEASTARO1genetic
27708008
WDR59_YEASTMTC5genetic
27708008
DHAS_YEASTHOM2genetic
27708008
UME6_YEASTUME6genetic
27708008
IPK1_YEASTIPK1genetic
27708008
STP1_YEASTSTP1genetic
27708008
SDC1_YEASTSDC1genetic
27708008
AK_YEASTHOM3genetic
27708008
IES1_YEASTIES1genetic
27708008
PIB2_YEASTPIB2genetic
27708008
AROC_YEASTARO2genetic
27708008
MED5_YEASTNUT1genetic
27708008
RTF1_YEASTRTF1genetic
27708008
SERB_YEASTSER2genetic
27708008
GOSR1_YEASTGOS1genetic
27708008
STB5_YEASTSTB5genetic
27708008
DAL81_YEASTDAL81genetic
27708008
VPS53_YEASTVPS53genetic
27708008
BCK1_YEASTBCK1genetic
27708008
BRE2_YEASTBRE2genetic
27708008
ERG3_YEASTERG3genetic
27708008
PKR1_YEASTPKR1genetic
27708008
ADE_YEASTAAH1genetic
27708008
SERC_YEASTSER1genetic
27708008
RUD3_YEASTRUD3genetic
27708008
LGE1_YEASTLGE1genetic
27708008
CHMU_YEASTARO7genetic
27708008
MED1_YEASTMED1genetic
27708008
GTR1_YEASTGTR1genetic
26387955
GTR2_YEASTGTR2genetic
26387955
LST7_YEASTLST7physical
26387955
GTR1_YEASTGTR1physical
26387955
GTR2_YEASTGTR2physical
26387955
LST7_YEASTLST7physical
28700931
IML1_YEASTIML1genetic
28700931
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LST4_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-547, AND MASSSPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-418, AND MASSSPECTROMETRY.

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