| UniProt ID | CWH41_YEAST | |
|---|---|---|
| UniProt AC | P53008 | |
| Protein Name | Mannosyl-oligosaccharide glucosidase {ECO:0000305} | |
| Gene Name | CWH41 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 833 | |
| Subcellular Localization |
Endoplasmic reticulum membrane Single-pass type II membrane protein . |
|
| Protein Description | Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor highly specifically. [PubMed: 9363442 Seems to play a role in beta-1,6-glucan synthesis] | |
| Protein Sequence | MLISKSKMFKTFWILTSIVLLASATVDISKLQEFEEYQKFTNESLLWAPYRSNCYFGMRPRYVHESPLIMGIMWFNSLSQDGLHSLRHFATPQDKLQKYGWEVYDPRIGGKEVFIDEKNNLNLTVYFVKSKNGENWSVRVQGEPLDPKRPSTASVVLYFSQNGGEIDGKSSLAMIGHDGPNDMKFFGYSKELGEYHLTVKDNFGHYFKNPEYETMEVAPGSDCSKTSHLSLQIPDKEVWKARDVFQSLVSDSIRDILEKEETKQRPADLIPSVLTIRNLYNFNPGNFHYIQKTFDLTKKDGFQFDITYNKLGTTQSISTREQVTELITWSLNEINARFDKQFSFGEGPDSIESVEVKRRFALETLSNLLGGIGYFYGNQLIDRETEFDESQFTEIKLLNAKEEGPFELFTSVPSRGFFPRGFYWDEGFHLLQIMEYDFDLAFEILASWFEMIEDDSGWIAREIILGNEARSKVPQEFQVQNPNIANPPTLLLAFSEMLSRAIENIGDFNSDSYHQVMFNSRTAKFMTNNLEANPGLLTEYAKKIYPKLLKHYNWFRKSQTGLIDEYEEILEDEGIWDKIHKNEVYRWVGRTFTHCLPSGMDDYPRAQPPDVAELNVDALAWVGVMTRSMKQIAHVLKLTQDEQRYAQIEQEVVENLDLLHWSENDNCYCDISIDPEDDEIREFVCHEGYVSVLPFALKLIPKNSPKLEKVVALMSDPEKIFSDYGLLSLSRQDDYFGKDENYWRGPIWMNINYLCLDAMRYYYPEVILDVAGEASNAKKLYQSLKINLSNNIYKVWEEQGYCYENYSPIDGHGTGAEHFTGWTALVVNILGRF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 42 | N-linked_Glycosylation | EEYQKFTNESLLWAP HHHHCCCCCCCCCCC | 39.74 | - | |
| 99 | Phosphorylation | PQDKLQKYGWEVYDP CHHHHHHHCCEEECC | 17.95 | 21126336 | |
| 122 | N-linked_Glycosylation | IDEKNNLNLTVYFVK EECCCCEEEEEEEEE | 35.47 | - | |
| 135 | N-linked_Glycosylation | VKSKNGENWSVRVQG EECCCCCCEEEEEEC | 37.41 | - | |
| 184 | Acetylation | HDGPNDMKFFGYSKE CCCCCCCEEEEECCC | 40.17 | 24489116 | |
| 221 | Phosphorylation | TMEVAPGSDCSKTSH EEEECCCCCCCCCCC | 34.09 | 19779198 | |
| 225 | Ubiquitination | APGSDCSKTSHLSLQ CCCCCCCCCCCEEEE | 61.45 | 17644757 | |
| 226 | Phosphorylation | PGSDCSKTSHLSLQI CCCCCCCCCCEEEEC | 12.70 | 19779198 | |
| 230 | Phosphorylation | CSKTSHLSLQIPDKE CCCCCCEEEECCCHH | 16.89 | 19779198 | |
| 236 | Ubiquitination | LSLQIPDKEVWKARD EEEECCCHHHHHHHH | 49.14 | 17644757 | |
| 240 | Acetylation | IPDKEVWKARDVFQS CCCHHHHHHHHHHHH | 38.43 | 24489116 | |
| 240 | Ubiquitination | IPDKEVWKARDVFQS CCCHHHHHHHHHHHH | 38.43 | 17644757 | |
| 313 | Phosphorylation | ITYNKLGTTQSISTR EEECCCCCCCCCCCH | 31.90 | 22369663 | |
| 314 | Phosphorylation | TYNKLGTTQSISTRE EECCCCCCCCCCCHH | 20.65 | 22369663 | |
| 316 | Phosphorylation | NKLGTTQSISTREQV CCCCCCCCCCCHHHH | 19.20 | 22369663 | |
| 318 | Phosphorylation | LGTTQSISTREQVTE CCCCCCCCCHHHHHH | 27.02 | 22369663 | |
| 319 | Phosphorylation | GTTQSISTREQVTEL CCCCCCCCHHHHHHH | 36.23 | 22369663 | |
| 510 | Phosphorylation | ENIGDFNSDSYHQVM HHHCCCCCCCCHHHH | 28.11 | 28889911 | |
| 513 | Phosphorylation | GDFNSDSYHQVMFNS CCCCCCCCHHHHCCC | 10.97 | 28889911 | |
| 520 | Phosphorylation | YHQVMFNSRTAKFMT CHHHHCCCCCHHHHC | 21.53 | 28889911 | |
| 527 | Phosphorylation | SRTAKFMTNNLEANP CCCHHHHCCCCCCCC | 24.88 | 27017623 | |
| 540 | Phosphorylation | NPGLLTEYAKKIYPK CCCHHHHHHHHHHHH | 20.63 | 23749301 | |
| 542 | Ubiquitination | GLLTEYAKKIYPKLL CHHHHHHHHHHHHHH | 38.51 | 23749301 | |
| 557 | Ubiquitination | KHYNWFRKSQTGLID HHHCCHHHCCCCCHH | 37.12 | 17644757 | |
| 578 | Ubiquitination | EDEGIWDKIHKNEVY HCCCCHHHHCCCHHH | 31.54 | 17644757 | |
| 787 | N-linked_Glycosylation | LYQSLKINLSNNIYK HHHHHCEECCCCHHH | 35.51 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CWH41_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CWH41_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CWH41_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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