BRE4_YEAST - dbPTM
BRE4_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID BRE4_YEAST
UniProt AC Q07660
Protein Name Protein BRE4
Gene Name BRE4
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1125
Subcellular Localization Membrane
Multi-pass membrane protein .
Protein Description May be involved in intracellular vesicle transport..
Protein Sequence MKRYERDRSPTPDPDIVKGSYSQTSLRSLHELNYKNPAGISGLSFAGSPQQSVASLSQMRLENLVKDKHWEEVEDFGLEELRDGFFDAAFTKPDSKARSPNSDIDDDNGAARKKLQSGFTKLSEYVWTAIYRPIIHFPRDIRKNGVSIFKFFIAYFIAIVICVIRPSGRWIGHEFRYFLPIAVLIHHPVRNIGVQLEMTISSIIGASFGLGWSALAWYISTATKPTANYQGGILFQSLTMALLFAIWLRSVYRRFFYFTTSFSISIIFTHTVRLASSKFDLKWQIFWDFGISYLFGLLLSLLVCVCVSPHSGNAELMEHYNKCLQTTKTFLMALVDTELIKSKEQIYLAQVKMVKTLNIDLSQGFRDFVNQLTISRFDLQSLKSLRNSLTAMETSLRVLPIAPKIFNDDELKKMYEELEKYRSDSATLSKEASASPQSSGIPTRENTPSAFKPIGPGLLKNEIYINALKASFSKSIFNLILEMIFVLENLSRVLKKYESPNQKNNLDECVKILSHSHSKLKRKIYKLDVCYRDFVNSSFFSQELLNDEESVDIFLFLRYLRNSARQLVTVIHDCQVLGENIHWRIALPSYPLSRALTRLPKQCVLDEGAGNVLHYFEAKRDVDEIFERVYNTYTSRHKYNKGEEEALRLDSQGGDEKSQNRKNHTISIRAIDHNDFNFHTTQNPWRFKLWKLSRILSGDECKWTLKITFCMIFLCLPTWLPESYHWYQEFHCWWAPLTFYLLAHRRYSGNWALVMRRLICGIVGIFWGWAANQSRHFGSPYVVCTFAGLIVVPFSINFLVYRNTKSSFTALMCFTIIALEPYSKPNRHYNLTTAGIWKSTWVTGLALIIGILVSIPINWIVWPFRARTELRDSMSSLLAHLGQSYQTVADRYLYRDADDAPTDLTFAFSHIREVRLTQSLEAIRELLKKARHEPIIISNFNPEKYASLINSCQFLLSKIIEARISGAFFEIWDQDFDIETTRALLSLRRDSVSSVIFVFYILSNCFRSKNKIPRYLPNPIMSRKKLYHFIKKFSEMKDQSHSNLNSGGNSMEKNLFKKIYQQKASSSGQQQLPLPSVANSSEIDSEKMHWTEVHGIAFARAFTDISEALFQVESCAKDILGEENF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
9PhosphorylationKRYERDRSPTPDPDI
CCCCCCCCCCCCCCC		37.1027214570
11PhosphorylationYERDRSPTPDPDIVK
CCCCCCCCCCCCCCC		41.3827214570
22PhosphorylationDIVKGSYSQTSLRSL
CCCCCCCCHHHHHHH		28.7821440633
24PhosphorylationVKGSYSQTSLRSLHE
CCCCCCHHHHHHHHH		24.6421440633
25PhosphorylationKGSYSQTSLRSLHEL
CCCCCHHHHHHHHHC		17.7221440633
28PhosphorylationYSQTSLRSLHELNYK
CCHHHHHHHHHCCCC		39.0921440633
95PhosphorylationAAFTKPDSKARSPNS
HHHCCCCCCCCCCCC		36.4227214570
102PhosphorylationSKARSPNSDIDDDNG
CCCCCCCCCCCCCCH		39.0527214570
430UbiquitinationSDSATLSKEASASPQ
CCCCCCCHHHCCCCC		61.4823749301
435PhosphorylationLSKEASASPQSSGIP
CCHHHCCCCCCCCCC		22.4527214570
447PhosphorylationGIPTRENTPSAFKPI
CCCCCCCCCCCCCCC		17.5427214570
464PhosphorylationGLLKNEIYINALKAS
CCCCCHHHHHHHHHH		5.0721440633
471PhosphorylationYINALKASFSKSIFN
HHHHHHHHHCHHHHH		28.5921440633
473PhosphorylationNALKASFSKSIFNLI
HHHHHHHCHHHHHHH		24.0121440633
651PhosphorylationEEALRLDSQGGDEKS
HHHHHCCCCCCCCCC		35.0027214570
697PhosphorylationWKLSRILSGDECKWT
HHHHHHHCCCCCCHH		41.6519684113
830N-linked_GlycosylationSKPNRHYNLTTAGIW
CCCCCCCCCCCCCCH		25.45-
884PhosphorylationLLAHLGQSYQTVADR
HHHHHHHHHHHHHHH		19.8727017623
887PhosphorylationHLGQSYQTVADRYLY
HHHHHHHHHHHHHHH		14.9327017623
894PhosphorylationTVADRYLYRDADDAP
HHHHHHHHCCCCCCC		9.4927017623
1040PhosphorylationFSEMKDQSHSNLNSG
HHHHCCCCCCCCCCC		38.7317287358
1042PhosphorylationEMKDQSHSNLNSGGN
HHCCCCCCCCCCCCC		48.5421551504
1046PhosphorylationQSHSNLNSGGNSMEK
CCCCCCCCCCCHHHH		51.7721551504
1050PhosphorylationNLNSGGNSMEKNLFK
CCCCCCCHHHHHHHH		31.4323749301
1060PhosphorylationKNLFKKIYQQKASSS
HHHHHHHHHHHCCCC		17.4827017623
1065PhosphorylationKIYQQKASSSGQQQL
HHHHHHCCCCCCCCC		31.8827214570
1066PhosphorylationIYQQKASSSGQQQLP
HHHHHCCCCCCCCCC		43.2627214570
1067PhosphorylationYQQKASSSGQQQLPL
HHHHCCCCCCCCCCC		37.8227214570
1080PhosphorylationPLPSVANSSEIDSEK
CCCCCCCCCCCCHHH		21.4327017623
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of BRE4_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of BRE4_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of BRE4_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CWH41_YEASTCWH41genetic
16269340
HMDH1_YEASTHMG1genetic
16269340
STE24_YEASTSTE24genetic
16269340
MTL1_YEASTMTL1genetic
20526336
BRO1_YEASTBRO1genetic
20526336
COG1_YEASTCOG1genetic
20526336
ARP4_YEASTARP4genetic
27708008
CWC16_YEASTYJU2genetic
27708008
SEC65_YEASTSEC65genetic
27708008
MCM1_YEASTMCM1genetic
27708008
CAP_YEASTSRV2genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of BRE4_YEAST

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Related Literatures of Post-Translational Modification

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