dbPTM

COG1_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	COG1_YEAST
UniProt AC	P53079
Protein Name	Conserved oligomeric Golgi complex subunit 1
Gene Name	COG1
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	417
Subcellular Localization	Golgi apparatus membrane Peripheral membrane protein Cytoplasmic side.
Protein Description	Acts as essential component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events..
Protein Sequence	MDEVLPLFRDSHIPQIKDYQLELQNDLTKTNEAFQKNLLKNYNKILSLTDSVNDLSLNLKNVDQDFKSLCFNDEKFQLNKLTPLPYQTTTHISPPRDEEKVSIPSQNILVISNWTISINNFCNRIVTSTTPSRIFDELLLNFHELSLIPVPSKFEALVKDKCCRLQKFLVDSMKTLNLTLLQWVKLYNLLNTEFSSKWDDDLLSIFNESLFETLFNDNVQALLISSANSKDHQYHSNQQYKDAIVVDFVNSSTFRDHLIRRTVKEINTHLDTLSTLRAKLKEPETLHKLDIFHDNDTNLNDGTVSPLDDDALKQYIDTAVFYSKGLTNDTTLQIYQTVQPTIEILQNLELYKCPQETLTDLRNKLITQLQEFKTQISSRLPSPLENSTSVVDDFITSYNNHNLLQLVIDQITQLRQQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
1	Acetylation	-------MDEVLPLF -------CCCCHHHH	10.01	22814378
305	Phosphorylation	NLNDGTVSPLDDDAL CCCCCCCCCCCHHHH	21.42	20377248

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of COG1_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of COG1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of COG1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
COG8_YEAST	COG8	physical	11703943
COG2_YEAST	COG2	physical	11703943
COG2_YEAST	COG2	physical	12011112
COG3_YEAST	COG3	physical	12011112
SED5_YEAST	SED5	physical	12011112
COG1_YEAST	COG1	physical	15932880
SLY1_YEAST	SLY1	genetic	12006647
PGTB2_YEAST	BET2	genetic	12006647
SEC17_YEAST	SEC17	genetic	12006647
COPG_YEAST	SEC21	genetic	12006647
COPB_YEAST	SEC26	genetic	12006647
COPB2_YEAST	SEC27	genetic	12006647
COG3_YEAST	COG3	genetic	12006647
COG2_YEAST	COG2	genetic	12006647
YPT6_YEAST	YPT6	genetic	12006647
COG6_YEAST	COG6	genetic	15932880
SEC12_YEAST	SEC12	genetic	12006647
SEC13_YEAST	SEC13	genetic	12006647
SEC16_YEAST	SEC16	genetic	12006647
COG6_YEAST	COG6	genetic	12006647
BET1_YEAST	BET1	genetic	12006647
SEC18_YEAST	SEC18	genetic	12006647
SEC22_YEAST	SEC22	genetic	12006647
SEC23_YEAST	SEC23	genetic	12006647
COPD_YEAST	RET2	genetic	12006647
SEC3_YEAST	SEC3	genetic	12006647
SEC4_YEAST	SEC4	genetic	12006647
SEC5_YEAST	SEC5	genetic	12006647
ATG17_YEAST	ATG17	physical	20065092
ATG20_YEAST	ATG20	physical	20065092
SNX4_YEAST	SNX4	physical	20065092
ERG4_YEAST	ERG4	genetic	20526336
MON2_YEAST	MON2	genetic	20526336
THRC_YEAST	THR4	genetic	20526336
MTL1_YEAST	MTL1	genetic	20526336
SRS2_YEAST	SRS2	genetic	21459050
COG3_YEAST	COG3	physical	23603116
COG4_YEAST	COG4	physical	23603116

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of COG1_YEAST

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-305, AND MASSSPECTROMETRY.	17563356 [Abstract]