| UniProt ID | SEC3_YEAST | |
|---|---|---|
| UniProt AC | P33332 | |
| Protein Name | Exocyst complex component SEC3 | |
| Gene Name | SEC3 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1336 | |
| Subcellular Localization | ||
| Protein Description | Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.. | |
| Protein Sequence | MRSSKSPFKRKSHSRETSHDENTSFFHKRTISGSSAHHSRNVSQGAVPSSAPPVSGGNYSHKRNVSRASNSSQTSNFLAEQYERDRKAIINCCFSRPDHKTGEPPNNYITHVRIIEDSKFPSSRPPPDSKLENKKKRLLILSAKPNNAKLIQIHKARENSDGSFQIGRTWQLTELVRVEKDLEISEGFILTMSKKYYWETNSAKERTVFIKSLITLYIQTFEGHVPELVNWDLSLFYLDERSYQRAVITNRPGSVSPIKSPTSNFTTNTTQSVGSVPFSAPTERTRRSETESVNPVSTPASVEYHAGMKSLNKAPYSSNSTLNEVNKRYELEQQQQQEEAELRRLEEQKRLQLQKENEMKRLEEERRIKQEERKRQMELEHQRQLEEEERKRQMELEAKKQMELKRQRQFEEEQRLKKERELLEIQRKQREQETAERLKKEEQEALAKKEEEEKSKRNKVDNESYTQEINGKVDNLLEDLNAVLAEETETTPTMQNGTYVPERSTARAHDQLKKPLNIAKVESLGGSDLNDSISLSDEIAGLNTSNLSGEDQDEKNDLSFEKGDEVRYSNNFEGEAPHVYHEVSIIQEEAPAVSQKLILPEENNESEALIESKEEIKTMENIDDEVLLEILTDINWSIEDDADSMIERIDLRLAETEYLFNQNLLSLQKIGPNIRPYEDKVNDECHRIIPTLSLFLMEMSNFSNDIENVESQDNGLQVESANKKLLWNTLDELLKTVSLDEISLNQLLECPIREKNLPWMENQLNLLLKAFQAIGSDGNEVEYNLREISGLKQRLQFYEKVTKIFLNRIVEEMQKKFSNIRGQDISHDQMIRILTTLLIFSPLILFCKEISQKSYQAIVENWNVSIQPVYMELWTKKISQLQGIDTNDEKMNELSLSQLLNEWDTFRKERKTNDINPVFKNSFSLLTECLQTMRQECIVYQNFVEVFFHISSKHNFEEYIKHFNDPDAPPILLDTVKVMQSDREAAVIETQLVSRIFQPIVTRLSSYFVELVKAEPTVAPALTFYLENEIKSLESSNHEFLLSAVTRMYTQIKQVWSDNVEEQVLHFERISNATTNGEILPGILDLPVGLKNSEDLFQFAKRSMDIKDTDEGYESIELMNSSFRKLSIAATRSITHKEVNSSINPNLSDTAALNNDYMETISLLVNSNWLTEMLSMLNFNKDGIFDTSLQNVKKVFDVEKESYASFLLRDTMPKLTAFVYGVSNIIENTNNVNMTNPSRWAAYSRQNLENILLAYTSHEIETLVKRLHTHMVNDFGYHQENAINNVLCDKLWSCIQGQTVSLYLKLYTVIDKHYRGTNIRFTKNDIISAFEEYKNA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 3 | Phosphorylation | -----MRSSKSPFKR -----CCCCCCCCCC | 54.71 | 19823750 | |
| 4 | Phosphorylation | ----MRSSKSPFKRK ----CCCCCCCCCCC | 43.30 | 19823750 | |
| 6 | Phosphorylation | --MRSSKSPFKRKSH --CCCCCCCCCCCCC | 37.20 | 19795423 | |
| 12 | Phosphorylation | KSPFKRKSHSRETSH CCCCCCCCCCCCCCC | 30.63 | 19823750 | |
| 14 | Phosphorylation | PFKRKSHSRETSHDE CCCCCCCCCCCCCCC | 38.61 | 20377248 | |
| 17 | Phosphorylation | RKSHSRETSHDENTS CCCCCCCCCCCCCCC | 30.19 | 20377248 | |
| 18 | Phosphorylation | KSHSRETSHDENTSF CCCCCCCCCCCCCCC | 24.96 | 20377248 | |
| 23 | Phosphorylation | ETSHDENTSFFHKRT CCCCCCCCCCCEECC | 25.51 | 21551504 | |
| 24 | Phosphorylation | TSHDENTSFFHKRTI CCCCCCCCCCEECCC | 37.18 | 21551504 | |
| 30 | Phosphorylation | TSFFHKRTISGSSAH CCCCEECCCCCCCCC | 25.05 | 19823750 | |
| 32 | Phosphorylation | FFHKRTISGSSAHHS CCEECCCCCCCCCCC | 31.82 | 19823750 | |
| 34 | Phosphorylation | HKRTISGSSAHHSRN EECCCCCCCCCCCCC | 19.98 | 20377248 | |
| 35 | Phosphorylation | KRTISGSSAHHSRNV ECCCCCCCCCCCCCC | 34.84 | 19823750 | |
| 39 | Phosphorylation | SGSSAHHSRNVSQGA CCCCCCCCCCCCCCC | 18.71 | 21440633 | |
| 43 | Phosphorylation | AHHSRNVSQGAVPSS CCCCCCCCCCCCCCC | 26.84 | 22369663 | |
| 49 | Phosphorylation | VSQGAVPSSAPPVSG CCCCCCCCCCCCCCC | 32.31 | 24961812 | |
| 50 | Phosphorylation | SQGAVPSSAPPVSGG CCCCCCCCCCCCCCC | 38.43 | 24961812 | |
| 55 | Phosphorylation | PSSAPPVSGGNYSHK CCCCCCCCCCCCCCC | 46.91 | 19823750 | |
| 59 | Phosphorylation | PPVSGGNYSHKRNVS CCCCCCCCCCCCCCC | 18.54 | 19823750 | |
| 60 | Phosphorylation | PVSGGNYSHKRNVSR CCCCCCCCCCCCCCC | 26.91 | 19823750 | |
| 62 | Acetylation | SGGNYSHKRNVSRAS CCCCCCCCCCCCCCC | 39.46 | 25381059 | |
| 66 | Phosphorylation | YSHKRNVSRASNSSQ CCCCCCCCCCCCCHH | 26.19 | 20377248 | |
| 69 | Phosphorylation | KRNVSRASNSSQTSN CCCCCCCCCCHHHHH | 35.81 | 19823750 | |
| 71 | Phosphorylation | NVSRASNSSQTSNFL CCCCCCCCHHHHHHH | 22.71 | 17330950 | |
| 72 | Phosphorylation | VSRASNSSQTSNFLA CCCCCCCHHHHHHHH | 41.55 | 17330950 | |
| 74 | Phosphorylation | RASNSSQTSNFLAEQ CCCCCHHHHHHHHHH | 27.82 | 20377248 | |
| 75 | Phosphorylation | ASNSSQTSNFLAEQY CCCCHHHHHHHHHHH | 20.25 | 17330950 | |
| 82 | Phosphorylation | SNFLAEQYERDRKAI HHHHHHHHHHHHHHH | 12.39 | 19823750 | |
| 119 | Acetylation | VRIIEDSKFPSSRPP EEEEECCCCCCCCCC | 73.87 | 24489116 | |
| 160 | Phosphorylation | IHKARENSDGSFQIG EEECCCCCCCCEEEC | 38.30 | 30377154 | |
| 163 | Phosphorylation | ARENSDGSFQIGRTW CCCCCCCCEEECCEE | 20.97 | 30377154 | |
| 185 | Phosphorylation | VEKDLEISEGFILTM EECCCCCCCCEEEEE | 23.45 | 28889911 | |
| 193 | Phosphorylation | EGFILTMSKKYYWET CCEEEEEEEEEEEEC | 22.29 | 28889911 | |
| 249 | Phosphorylation | SYQRAVITNRPGSVS HEEEEEEECCCCCCC | 20.69 | 22369663 | |
| 254 | Phosphorylation | VITNRPGSVSPIKSP EEECCCCCCCCCCCC | 23.31 | 22369663 | |
| 256 | Phosphorylation | TNRPGSVSPIKSPTS ECCCCCCCCCCCCCC | 23.70 | 22369663 | |
| 260 | Phosphorylation | GSVSPIKSPTSNFTT CCCCCCCCCCCCCCC | 33.84 | 23749301 | |
| 262 | Phosphorylation | VSPIKSPTSNFTTNT CCCCCCCCCCCCCCC | 43.31 | 29688323 | |
| 263 | Phosphorylation | SPIKSPTSNFTTNTT CCCCCCCCCCCCCCC | 33.07 | 19779198 | |
| 266 | Phosphorylation | KSPTSNFTTNTTQSV CCCCCCCCCCCCCCC | 24.32 | 27738172 | |
| 269 | Phosphorylation | TSNFTTNTTQSVGSV CCCCCCCCCCCCCCC | 24.91 | 27738172 | |
| 285 | Phosphorylation | FSAPTERTRRSETES CCCCCCCCCCCCCCC | 24.97 | 17330950 | |
| 288 | Phosphorylation | PTERTRRSETESVNP CCCCCCCCCCCCCCC | 45.65 | 21440633 | |
| 290 | Phosphorylation | ERTRRSETESVNPVS CCCCCCCCCCCCCCC | 34.50 | 17330950 | |
| 297 | Phosphorylation | TESVNPVSTPASVEY CCCCCCCCCCCHHHH | 29.90 | 28889911 | |
| 298 | Phosphorylation | ESVNPVSTPASVEYH CCCCCCCCCCHHHHH | 24.10 | 19779198 | |
| 301 | Phosphorylation | NPVSTPASVEYHAGM CCCCCCCHHHHHCCC | 19.38 | 23749301 | |
| 304 | Phosphorylation | STPASVEYHAGMKSL CCCCHHHHHCCCCCC | 8.53 | 19779198 | |
| 316 | Phosphorylation | KSLNKAPYSSNSTLN CCCCCCCCCCCCHHH | 29.59 | 22369663 | |
| 317 | Phosphorylation | SLNKAPYSSNSTLNE CCCCCCCCCCCHHHH | 23.22 | 22369663 | |
| 318 | Phosphorylation | LNKAPYSSNSTLNEV CCCCCCCCCCHHHHH | 29.02 | 22369663 | |
| 320 | Phosphorylation | KAPYSSNSTLNEVNK CCCCCCCCHHHHHHH | 35.90 | 22369663 | |
| 321 | Phosphorylation | APYSSNSTLNEVNKR CCCCCCCHHHHHHHH | 37.54 | 22369663 | |
| 327 | Ubiquitination | STLNEVNKRYELEQQ CHHHHHHHHHHHHHH | 62.63 | 23749301 | |
| 459 | Ubiquitination | EEKSKRNKVDNESYT HHHHHHHCCCCHHHH | 55.81 | 23749301 | |
| 464 | Phosphorylation | RNKVDNESYTQEING HHCCCCHHHHHHHCH | 39.47 | 19823750 | |
| 465 | Phosphorylation | NKVDNESYTQEINGK HCCCCHHHHHHHCHH | 13.28 | 28889911 | |
| 466 | Phosphorylation | KVDNESYTQEINGKV CCCCHHHHHHHCHHH | 29.07 | 25752575 | |
| 527 | Phosphorylation | KVESLGGSDLNDSIS EHHHCCCCCCCCCCC | 36.81 | 21551504 | |
| 534 | Phosphorylation | SDLNDSISLSDEIAG CCCCCCCCHHHHHCC | 26.27 | 21551504 | |
| 548 | Phosphorylation | GLNTSNLSGEDQDEK CCCCCCCCCCCCCCC | 44.37 | 28889911 | |
| 559 | Phosphorylation | QDEKNDLSFEKGDEV CCCCCCCCCCCCCEE | 33.93 | 25521595 | |
| 568 | Phosphorylation | EKGDEVRYSNNFEGE CCCCEEEECCCCCCC | 22.41 | 20377248 | |
| 569 | Phosphorylation | KGDEVRYSNNFEGEA CCCEEEECCCCCCCC | 18.09 | 21551504 | |
| 580 | Phosphorylation | EGEAPHVYHEVSIIQ CCCCCCEEEEEEEEC | 6.82 | 21440633 | |
| 584 | Phosphorylation | PHVYHEVSIIQEEAP CCEEEEEEEECCCCC | 15.81 | 19779198 | |
| 606 | Phosphorylation | LPEENNESEALIESK CCCCCCCCHHHHCCH | 30.23 | 21551504 | |
| 612 | Phosphorylation | ESEALIESKEEIKTM CCHHHHCCHHHHHHH | 38.07 | 24961812 | |
| 613 | Ubiquitination | SEALIESKEEIKTME CHHHHCCHHHHHHHC | 46.72 | 23749301 | |
| 658 | Phosphorylation | LRLAETEYLFNQNLL HHHHHHHHHHCCCCC | 24.82 | 27017623 | |
| 666 | Phosphorylation | LFNQNLLSLQKIGPN HHCCCCCHHHHHCCC | 31.74 | 27017623 | |
| 800 | Acetylation | QRLQFYEKVTKIFLN HHHHHHHHHHHHHHH | 43.77 | 24489116 | |
| 912 | Phosphorylation | TFRKERKTNDINPVF HHHHHHCCCCCCHHH | 44.32 | 27017623 | |
| 1103 | Phosphorylation | LFQFAKRSMDIKDTD HHHHHHHHCCCCCCC | 21.79 | 27017623 | |
| 1109 | Phosphorylation | RSMDIKDTDEGYESI HHCCCCCCCCCHHHH | 30.83 | 27017623 | |
| 1113 | Phosphorylation | IKDTDEGYESIELMN CCCCCCCHHHHHHHH | 12.40 | 27017623 | |
| 1115 | Phosphorylation | DTDEGYESIELMNSS CCCCCHHHHHHHHHH | 16.93 | 27017623 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SEC3_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SEC3_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SEC3_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-43; SER-69; SER-72;THR-74; SER-75; SER-317; SER-318; SER-320; THR-321; SER-464; TYR-465;SER-548 AND SER-606, AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-318 AND SER-464, ANDMASS SPECTROMETRY. | |
| "Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14 AND SER-18, AND MASSSPECTROMETRY. | |
| "Phosphoproteome analysis by mass spectrometry and its application toSaccharomyces cerevisiae."; Ficarro S.B., McCleland M.L., Stukenberg P.T., Burke D.J., Ross M.M.,Shabanowitz J., Hunt D.F., White F.M.; Nat. Biotechnol. 20:301-305(2002). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-32 AND SER-35, AND MASSSPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-290, AND MASSSPECTROMETRY. | |
