GYP3_YEAST - dbPTM
GYP3_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GYP3_YEAST
UniProt AC P48566
Protein Name GTPase-activating protein GYP3
Gene Name MSB3
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 633
Subcellular Localization Cytoplasm . Bud . Bud neck . Localizes to the presumptive bud site, the bud tip and the mother-bud neck.
Protein Description Regulates exocytosis by functioning as a GAP for SEC4. Stimulates specifically the GTPase activity of YPT6. Also required for efficient polarization of the actin patches..
Protein Sequence MQNDQQRFSLQNRTVLAHPYKRLGGAFTVKSPSVPNFHDKMHSDHSSSDSALVNGSFRANDHRSVEPSCLGQASPSEHDGNLSVIDLYGDEVESQRAEGEDDDDNNGDNGNEDLEEVHSDDLDLVPDDDNRQRVELEGAASATSANSNGINNTHFDRYGFKKQNNYISEAEYDKWWVEYSQYCVRRKHKWQLLLEKSGLPVTDDSPSRFPSKSERLKRYVRKGIPAEWRGNAWWHFARGQEKLNKNKGVYSQLLRKMKQIKKQNPNEKQVQDLDIIERDLNRTFPDNIHFQSSLHNKEGPPIIKSLRRVLVAFSLYNPKIGYCQSMNFLAGLLLLFLDEERAFWMLVIITSRYLPGVHNINLEGVNIDQGVLMLCVKEYIPEVWSYIKPSIDHHQKNNKTFSPSNKKVLFNMQKNEFLYRLPPITLCTASWFMSCFVGVVPIETTLRIWDCLFYEESHFLFKVSLAVLKLSEHDLSKIKPRNNSLNYSWGSNLNQRGGSMGQEDSDMEIFQVIQTFPKTLLNPNEIFEKIIFKRRFNLNRLDQDEIDRCRKFVAAQRLKFKTYGELLGNSTSEADLPINDNTDNKGIHITSDAVNEALSSEVYGFKKSLAGVHWNNSIKEKVKQMRKKKDKGD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
9PhosphorylationQNDQQRFSLQNRTVL
CCHHHHHHHCCCCEE		31.1024909858
31PhosphorylationGGAFTVKSPSVPNFH
CCEEEECCCCCCCCC		20.3322369663
33PhosphorylationAFTVKSPSVPNFHDK
EEEECCCCCCCCCHH		58.2422369663
43PhosphorylationNFHDKMHSDHSSSDS
CCCHHCCCCCCCCCC		33.2622369663
46PhosphorylationDKMHSDHSSSDSALV
HHCCCCCCCCCCCHH		36.2122369663
47PhosphorylationKMHSDHSSSDSALVN
HCCCCCCCCCCCHHC		34.4422369663
48PhosphorylationMHSDHSSSDSALVNG
CCCCCCCCCCCHHCC		38.3022369663
50PhosphorylationSDHSSSDSALVNGSF
CCCCCCCCCHHCCCC		26.0022369663
68PhosphorylationDHRSVEPSCLGQASP
CCCCCCHHHCCCCCC		14.4128889911
74PhosphorylationPSCLGQASPSEHDGN
HHHCCCCCCCCCCCC		22.5228889911
76PhosphorylationCLGQASPSEHDGNLS
HCCCCCCCCCCCCEE		45.1028889911
83PhosphorylationSEHDGNLSVIDLYGD
CCCCCCEEEEECCCH		22.4927017623
94PhosphorylationLYGDEVESQRAEGED
CCCHHHHHHCCCCCC		30.0928889911
119PhosphorylationEDLEEVHSDDLDLVP
CCHHHHHHCCCCCCC		37.6928889911
141PhosphorylationVELEGAASATSANSN
EEEECCCCCCCCCCC		31.3923749301
143PhosphorylationLEGAASATSANSNGI
EECCCCCCCCCCCCC		26.3623749301
144PhosphorylationEGAASATSANSNGIN
ECCCCCCCCCCCCCC		25.7723749301
147PhosphorylationASATSANSNGINNTH
CCCCCCCCCCCCCCC		35.8323749301
189AcetylationYCVRRKHKWQLLLEK
HHHHHHHHHHHHHHH		39.4024489116
484PhosphorylationKIKPRNNSLNYSWGS
HCCCCCCCCCCCCCC		22.8828889911
499PhosphorylationNLNQRGGSMGQEDSD
CCCCCCCCCCCCCCH		23.6730377154
505PhosphorylationGSMGQEDSDMEIFQV
CCCCCCCCHHHHHHH		37.8030377154
562PhosphorylationAQRLKFKTYGELLGN
HHHHCCCCHHHHCCC		39.6321126336
570PhosphorylationYGELLGNSTSEADLP
HHHHCCCCCCCCCCC		31.3521440633
571PhosphorylationGELLGNSTSEADLPI
HHHCCCCCCCCCCCC		34.2928889911
572PhosphorylationELLGNSTSEADLPIN
HHCCCCCCCCCCCCC		30.5227214570
617PhosphorylationAGVHWNNSIKEKVKQ
CCCCCCHHHHHHHHH		31.6521440633
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GYP3_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GYP3_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GYP3_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
BNI1_YEASTBNI1physical
11489916
SPA2_YEASTSPA2physical
11489916
SEC4_YEASTSEC4physical
10559187
YPT6_YEASTYPT6physical
10559187
VPS21_YEASTVPS21physical
10559187
YPT31_YEASTYPT31physical
10559187
SPA2_YEASTSPA2physical
16166638
BNI1_YEASTBNI1physical
16166638
BUD6_YEASTBUD6physical
16166638
PEA2_YEASTPEA2physical
16166638
RHO1_YEASTRHO1physical
16166638
MSB4_YEASTMSB4genetic
12913108
MSB4_YEASTMSB4genetic
10923023
MSB4_YEASTMSB4genetic
10679030
SA155_YEASTSAP155genetic
16231214
SSZ1_YEASTSSZ1genetic
16231214
HSP73_YEASTSSA3physical
16554755
YRA1_YEASTYRA1physical
16554755
GTT3_YEASTGTT3physical
16554755
IF5A1_YEASTHYP2physical
16554755
YG36_YEASTYGR126Wphysical
16554755
LSM12_YEASTLSM12physical
16554755
OSH2_YEASTOSH2genetic
17004323
KES1_YEASTKES1genetic
17004323
SEC4_YEASTSEC4physical
10937877
YPT6_YEASTYPT6physical
10937877
VPS21_YEASTVPS21physical
10937877
MSB4_YEASTMSB4genetic
16099424
CIC1_YEASTCIC1genetic
16231214
USO1_YEASTUSO1genetic
16231214
VPS35_YEASTVPS35genetic
16231214
SEC7_YEASTSEC7genetic
16231214
ADH1_YEASTADH1genetic
20872164
RNT1_YEASTRNT1genetic
20872164
SUI1_YEASTSUI1genetic
20872164
YAP6_YEASTYAP6genetic
20872164
ZEO1_YEASTZEO1genetic
20872164
SLM1_YEASTSLM1genetic
20872164
RV161_YEASTRVS161genetic
20526336
RV167_YEASTRVS167genetic
20526336
PER1_YEASTPER1genetic
20526336
PRM9_YEASTPRM9genetic
20526336
MSB4_YEASTMSB4genetic
21363887
SRS2_YEASTSRS2genetic
21459050
BEM1_YEASTBEM1genetic
21987634
NUM1_YEASTNUM1genetic
21987634
GET1_YEASTGET1genetic
21987634
ARP1_YEASTARP1genetic
21987634
CDC42_YEASTCDC42genetic
21987634
US6NL_HUMANUSP6NLgenetic
14521938
PP2C1_YEASTPTC1genetic
23924898
CDC1_YEASTCDC1genetic
27708008
RS8A_YEASTRPS8Agenetic
27708008
RS8B_YEASTRPS8Agenetic
27708008
SWI6_YEASTSWI6genetic
27708008
APC11_YEASTAPC11genetic
27708008
ACT_YEASTACT1genetic
27708008
NU192_YEASTNUP192genetic
27708008
SEC22_YEASTSEC22genetic
27708008
MCM1_YEASTMCM1genetic
27708008
ROT1_YEASTROT1genetic
27708008
GPI12_YEASTGPI12genetic
27708008
CSG2_YEASTCSG2genetic
27708008
MBA1_YEASTMBA1genetic
27708008
RS14A_YEASTRPS14Agenetic
27708008
NUM1_YEASTNUM1genetic
27708008
RV167_YEASTRVS167genetic
27708008
MRM2_YEASTMRM2genetic
27708008
ATC1_YEASTPMR1genetic
27708008
IRE1_YEASTIRE1genetic
27708008
PTH_YEASTPTH1genetic
27708008
FLX1_YEASTFLX1genetic
27708008
ICS3_YEASTICS3genetic
27708008
PTK2_YEASTPTK2genetic
27708008
RL43A_YEASTRPL43Bgenetic
27708008
RL43B_YEASTRPL43Bgenetic
27708008
MIC60_YEASTMIC60genetic
27708008
LDB18_YEASTLDB18genetic
27708008
EIF3J_YEASTHCR1genetic
27708008
CG24_YEASTCLB4genetic
27708008
ATP10_YEASTATP10genetic
27708008
PKR1_YEASTPKR1genetic
27708008
JNM1_YEASTJNM1genetic
27708008
COQ2_YEASTCOQ2genetic
27708008
CSI2_YEASTCSI2genetic
27708008
GSHB_YEASTGSH2genetic
27708008
DCAM_YEASTSPE2genetic
27708008
HMI1_YEASTHMI1genetic
27708008
MSB4_YEASTMSB4genetic
27708008
MSN1_YEASTMSN1genetic
27708008
COQ7_YEASTCAT5genetic
27708008
LIS1_YEASTPAC1genetic
27708008
MSC6_YEASTMSC6genetic
27708008
NIP80_YEASTNIP100genetic
27708008
UBA3_YEASTUBA3genetic
27708008
SPEE_YEASTSPE3genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GYP3_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-570 AND SER-572, ANDMASS SPECTROMETRY.

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