| UniProt ID | USO1_YEAST | |
|---|---|---|
| UniProt AC | P25386 | |
| Protein Name | Intracellular protein transport protein USO1 | |
| Gene Name | USO1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1790 | |
| Subcellular Localization |
Cytoplasm, cytoskeleton. Cytoplasmic vesicle membrane Peripheral membrane protein . Endoplasmic reticulum membrane Peripheral membrane protein . Golgi apparatus membrane Peripheral membrane protein . Probably present on vesicles operational bet |
|
| Protein Description | Required for protein transport from the ER to the Golgi complex.. | |
| Protein Sequence | MDIIQGLIQQPKIQSVDETIPTLCDRVENSTLISDRRSAVLGLKAFSRQYRESVIASGLKPLLNTLKRDYMDEDSVKAILETILILFIRGDGHDDLTRGWISQQSRLQNGKYPSPLVMKQEKEQVDQFSLWIADALTQSEDLIHLLVEFWEIDNFHIRLYTIQLLEAVMATRPLKARSALISLPTSISTMVSLLDDMHEPIRDEAILLLMAVVNDSPHVQKLVAFENIFERLFSIIEEEGGLRGSLVVNDCLSLINNILKYNTSNQTLFLETGNLPKLAHLLSEPISQDEVFFWNDQRIVNINTALDIVSLTVEPGNTVTTKHQNALLDSSVLMVVLRLAFFHNIPKKVRPVALLTAANMVRSNEHAQLEFSKIDVPYFDPSLPVNSTANGGPIKLIPVVSILINWMLYANSVHTFDTRVACSRLLKAYFMDNFDLQRDFLLKQVQLCNNSTNNVGDNAKENGGSNKSDKESDSDKDTDGKDGTEYEGSFKANLFEVLLNYDAELNLNPFKLFFTTDIFMFFFQQDHKYSEELREITRNVTTGNDLEDEEPLKAIQTISELLTTSLTAADIRIPISYLTFLIYWLFGDFKATNDFLSDKSVIKSLLSFSYQIQDEDVTIKCLVTMLLGVAYEFSSKESPFPRKEYFEFITKTLGKDNYASRIKQFKKDSYFSKVDMNEDSILTPELDETGLPKVYFSTYFIQLFNENIYRIRTALSHDPDEEPINKISFEEVEKLQRQCTKLKGEITSLQTETESTHENLTEKLIALTNEHKELDEKYQILNSSHSSLKENFSILETELKNVRDSLDEMTQLRDVLETKDKENQTALLEYKSTIHKQEDSIKTLEKGLETILSQKKKAEDGINKMGKDLFALSREMQAVEENCKNLQKEKDKSNVNHQKETKSLKEDIAAKITEIKAINENLEEMKIQCNNLSKEKEHISKELVEYKSRFQSHDNLVAKLTEKLKSLANNYKDMQAENESLIKAVEESKNESSIQLSNLQNKIDSMSQEKENFQIERGSIEKNIEQLKKTISDLEQTKEEIISKSDSSKDEYESQISLLKEKLETATTANDENVNKISELTKTREELEAELAAYKNLKNELETKLETSEKALKEVKENEEHLKEEKIQLEKEATETKQQLNSLRANLESLEKEHEDLAAQLKKYEEQIANKERQYNEEISQLNDEITSTQQENESIKKKNDELEGEVKAMKSTSEEQSNLKKSEIDALNLQIKELKKKNETNEASLLESIKSVESETVKIKELQDECNFKEKEVSELEDKLKASEDKNSKYLELQKESEKIKEELDAKTTELKIQLEKITNLSKAKEKSESELSRLKKTSSEERKNAEEQLEKLKNEIQIKNQAFEKERKLLNEGSSTITQEYSEKINTLEDELIRLQNENELKAKEIDNTRSELEKVSLSNDELLEEKQNTIKSLQDEILSYKDKITRNDEKLLSIERDNKRDLESLKEQLRAAQESKAKVEEGLKKLEEESSKEKAELEKSKEMMKKLESTIESNETELKSSMETIRKSDEKLEQSKKSAEEDIKNLQHEKSDLISRINESEKDIEELKSKLRIEAKSGSELETVKQELNNAQEKIRINAEENTVLKSKLEDIERELKDKQAEIKSNQEEKELLTSRLKELEQELDSTQQKAQKSEEERRAEVRKFQVEKSQLDEKAMLLETKYNDLVNKEQAWKRDEDTVKKTTDSQRQEIEKLAKELDNLKAENSKLKEANEDRSEIDDLMLLVTDLDEKNAKYRSKLKDLGVEISSDEEDDEEDDEEDEEEGQVA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 119 | Methylation | YPSPLVMKQEKEQVD CCCCCCHHHHHHHHH | 48.07 | 20137074 | |
| 178 | Phosphorylation | TRPLKARSALISLPT CCCCCHHHHHHHCCC | 32.08 | 19779198 | |
| 188 | Phosphorylation | ISLPTSISTMVSLLD HHCCCCHHHHHHHHH | 15.37 | 19779198 | |
| 192 | Phosphorylation | TSISTMVSLLDDMHE CCHHHHHHHHHCCCC | 16.64 | 19779198 | |
| 472 | Phosphorylation | SNKSDKESDSDKDTD CCCCCCCCCCCCCCC | 48.43 | 27717283 | |
| 474 | Phosphorylation | KSDKESDSDKDTDGK CCCCCCCCCCCCCCC | 56.70 | 28889911 | |
| 478 | Phosphorylation | ESDSDKDTDGKDGTE CCCCCCCCCCCCCCE | 53.01 | 27717283 | |
| 734 | Acetylation | ISFEEVEKLQRQCTK CCHHHHHHHHHHHHH | 55.91 | 24489116 | |
| 778 | Phosphorylation | HKELDEKYQILNSSH HHHHHHHHHHHHCCC | 9.95 | 29688323 | |
| 786 | Phosphorylation | QILNSSHSSLKENFS HHHHCCCHHHHHHHH | 39.04 | 27017623 | |
| 787 | Phosphorylation | ILNSSHSSLKENFSI HHHCCCHHHHHHHHH | 37.73 | 27017623 | |
| 840 | Phosphorylation | TIHKQEDSIKTLEKG HHHHCHHHHHHHHHH | 25.82 | 28889911 | |
| 843 | Phosphorylation | KQEDSIKTLEKGLET HCHHHHHHHHHHHHH | 38.18 | 28889911 | |
| 846 | Acetylation | DSIKTLEKGLETILS HHHHHHHHHHHHHHH | 72.42 | 24489116 | |
| 850 | Phosphorylation | TLEKGLETILSQKKK HHHHHHHHHHHHHHH | 32.06 | 19779198 | |
| 867 | Acetylation | DGINKMGKDLFALSR HHHHHHHHHHHHHHH | 48.00 | 24489116 | |
| 952 | Phosphorylation | EYKSRFQSHDNLVAK HHHHHHHCCCHHHHH | 30.05 | 23749301 | |
| 959 | Acetylation | SHDNLVAKLTEKLKS CCCHHHHHHHHHHHH | 48.76 | 24489116 | |
| 966 | Phosphorylation | KLTEKLKSLANNYKD HHHHHHHHHHHCHHH | 43.05 | 28889911 | |
| 971 | Phosphorylation | LKSLANNYKDMQAEN HHHHHHCHHHHHHHH | 14.26 | 28889911 | |
| 972 | Ubiquitination | KSLANNYKDMQAENE HHHHHCHHHHHHHHH | 49.17 | 23749301 | |
| 972 | Acetylation | KSLANNYKDMQAENE HHHHHCHHHHHHHHH | 49.17 | 24489116 | |
| 980 | Phosphorylation | DMQAENESLIKAVEE HHHHHHHHHHHHHHH | 47.15 | 28889911 | |
| 993 | Phosphorylation | EESKNESSIQLSNLQ HHHCCCCCCCHHHHH | 14.26 | 28889911 | |
| 1030 | Phosphorylation | NIEQLKKTISDLEQT HHHHHHHHHHHHHHH | 24.91 | 27017623 | |
| 1032 | Phosphorylation | EQLKKTISDLEQTKE HHHHHHHHHHHHHHH | 41.18 | 17563356 | |
| 1049 | Acetylation | ISKSDSSKDEYESQI HHCCCCCHHHHHHHH | 59.54 | 24489116 | |
| 1062 | Ubiquitination | QISLLKEKLETATTA HHHHHHHHHHHCCCC | 50.46 | 23749301 | |
| 1104 | Acetylation | LKNELETKLETSEKA HHHHHHHHHHHHHHH | 34.64 | 24489116 | |
| 1152 | Acetylation | ANLESLEKEHEDLAA HHHHHHHHHHHHHHH | 70.44 | 24489116 | |
| 1318 | Acetylation | ELKIQLEKITNLSKA HHHHHHHHHHCHHHH | 64.52 | 24489116 | |
| 1367 | Ubiquitination | IKNQAFEKERKLLNE HHHHHHHHHHHHHHC | 57.26 | 23749301 | |
| 1419 | Phosphorylation | RSELEKVSLSNDELL HHHHHHHCCCCHHHH | 36.83 | 27017623 | |
| 1421 | Phosphorylation | ELEKVSLSNDELLEE HHHHHCCCCHHHHHH | 34.43 | 27017623 | |
| 1429 | Acetylation | NDELLEEKQNTIKSL CHHHHHHHHHHHHHH | 39.20 | 24489116 | |
| 1444 | Acetylation | QDEILSYKDKITRND HHHHHHCHHHCCCCC | 49.52 | 24489116 | |
| 1446 | Acetylation | EILSYKDKITRNDEK HHHHCHHHCCCCCHH | 41.65 | 24489116 | |
| 1453 | Acetylation | KITRNDEKLLSIERD HCCCCCHHHHHHCCC | 58.55 | 24489116 | |
| 1554 | Phosphorylation | KNLQHEKSDLISRIN HHHHHHHHHHHHHHC | 34.36 | 30377154 | |
| 1565 | Succinylation | SRINESEKDIEELKS HHHCCCHHHHHHHHH | 73.60 | 23954790 | |
| 1565 | Acetylation | SRINESEKDIEELKS HHHCCCHHHHHHHHH | 73.60 | 24489116 | |
| 1571 | Acetylation | EKDIEELKSKLRIEA HHHHHHHHHHHHHEE | 49.15 | 24489116 | |
| 1610 | Phosphorylation | EENTVLKSKLEDIER HHHHHHHHHHHHHHH | 38.01 | 24909858 | |
| 1656 | Acetylation | STQQKAQKSEEERRA HHHHHHHHCHHHHHH | 65.77 | 22865919 | |
| 1678 | Acetylation | EKSQLDEKAMLLETK HHHHHHHHHHHHHHH | 38.47 | 24489116 | |
| 1685 | Acetylation | KAMLLETKYNDLVNK HHHHHHHHHHHHCCH | 32.45 | 24489116 | |
| 1692 | Acetylation | KYNDLVNKEQAWKRD HHHHHCCHHHHHHCC | 43.66 | 24489116 | |
| 1770 | Phosphorylation | KDLGVEISSDEEDDE HHHCCCCCCCCCCCC | 20.45 | 19684113 | |
| 1771 | Phosphorylation | DLGVEISSDEEDDEE HHCCCCCCCCCCCCC | 55.49 | 19684113 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of USO1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of USO1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of USO1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1032, AND MASSSPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1032, AND MASSSPECTROMETRY. | |
