IDI1_YEAST - dbPTM
IDI1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID IDI1_YEAST
UniProt AC P15496
Protein Name Isopentenyl-diphosphate Delta-isomerase
Gene Name IDI1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 288
Subcellular Localization Cytoplasm.
Protein Description Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)..
Protein Sequence MTADNNSMPHGAVSSYAKLVQNQTPEDILEEFPEIIPLQQRPNTRSSETSNDESGETCFSGHDEEQIKLMNENCIVLDWDDNAIGAGTKKVCHLMENIEKGLLHRAFSVFIFNEQGELLLQQRATEKITFPDLWTNTCCSHPLCIDDELGLKGKLDDKIKGAITAAVRKLDHELGIPEDETKTRGKFHFLNRIHYMAPSNEPWGEHEIDYILFYKINAKENLTVNPNVNEVRDFKWVSPNDLKTMFADPSYKFTPWFKIICENYLFNWWEQLDDLSEVENDRQIHRML
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MTADNNSMP
------CCCCCCCCC		42.5922369663
7Phosphorylation-MTADNNSMPHGAVS
-CCCCCCCCCCCHHH		39.6922369663
14PhosphorylationSMPHGAVSSYAKLVQ
CCCCCHHHHHHHHHC		19.6622369663
15PhosphorylationMPHGAVSSYAKLVQN
CCCCHHHHHHHHHCC		23.6322369663
16PhosphorylationPHGAVSSYAKLVQNQ
CCCHHHHHHHHHCCC		10.5522369663
24PhosphorylationAKLVQNQTPEDILEE
HHHHCCCCHHHHHHH		35.8717563356
46PhosphorylationQQRPNTRSSETSNDE
CCCCCCCCCCCCCCC		30.4119779198
49PhosphorylationPNTRSSETSNDESGE
CCCCCCCCCCCCCCC		34.4728889911
50PhosphorylationNTRSSETSNDESGET
CCCCCCCCCCCCCCC		37.9317330950
57PhosphorylationSNDESGETCFSGHDE
CCCCCCCCCCCCCCH		23.5228889911
60PhosphorylationESGETCFSGHDEEQI
CCCCCCCCCCCHHHH		37.0525315811
100AcetylationHLMENIEKGLLHRAF
HHHHHHHHCHHHHHH		51.5724489116
169UbiquitinationAITAAVRKLDHELGI
HHHHHHHHHHHHHCC		52.2323749301
169AcetylationAITAAVRKLDHELGI
HHHHHHHHHHHHHCC		52.2324489116
182AcetylationGIPEDETKTRGKFHF
CCCCCCCCCCCCEEE		33.8924489116
186AcetylationDETKTRGKFHFLNRI
CCCCCCCCEEECCCE		32.1624489116
219UbiquitinationLFYKINAKENLTVNP
EEEEECCCCCEEECC		42.5223749301
235AcetylationVNEVRDFKWVSPNDL
CCCCEECEEECHHHH		51.4824489116
243UbiquitinationWVSPNDLKTMFADPS
EECHHHHHHHCCCCC		40.5823749301
243AcetylationWVSPNDLKTMFADPS
EECHHHHHHHCCCCC		40.5824489116
252UbiquitinationMFADPSYKFTPWFKI
HCCCCCCCCCHHHHH		47.2823749301
252AcetylationMFADPSYKFTPWFKI
HCCCCCCCCCHHHHH		47.2824489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of IDI1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of IDI1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of IDI1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MED10_YEASTNUT2physical
18467557
KCS1_YEASTKCS1genetic
21623372
GPDM_YEASTGUT2genetic
21623372
GLRX1_YEASTGRX1genetic
21623372
LCB5_YEASTLCB5genetic
21623372
SYSM_YEASTDIA4genetic
21623372
TPS2_YEASTTPS2genetic
21623372
THRC_YEASTTHR4genetic
21623372
FOLE_YEASTMET7genetic
21623372
COX6_YEASTCOX6genetic
21623372
ATP14_YEASTATP14genetic
21623372
GPP2_YEASTGPP2genetic
21623372
ACON_YEASTACO1genetic
21623372
MET10_YEASTMET10genetic
21623372
ATPO_YEASTATP5genetic
21623372
ELO3_YEASTELO3genetic
21623372
QCR2_YEASTQCR2genetic
21623372
METX_YEASTYML082Wgenetic
21623372
GSH1_YEASTGSH1genetic
21623372
IPK1_YEASTIPK1genetic
21623372
DDP1_YEASTDDP1genetic
21623372
CBS_YEASTCYS4genetic
21623372
CYS3_YEASTCYS3genetic
21623372
PHSG_YEASTGPH1genetic
21623372
MCM1_YEASTMCM1genetic
27708008
ATG15_YEASTATG15genetic
27708008
MRM2_YEASTMRM2genetic
27708008
PET8_YEASTPET8genetic
27708008
CY1_YEASTCYT1genetic
27708008
SEF1_YEASTSEF1genetic
27708008
SCM4_YEASTSCM4genetic
27708008
PMS1_YEASTPMS1genetic
27708008
STU1_YEASTSTU1genetic
27708008
GNA1_YEASTGNA1genetic
27708008
SEC22_YEASTSEC22genetic
27708008
PRP9_YEASTPRP9genetic
27708008
LCB2_YEASTLCB2genetic
27708008
SMT3_YEASTSMT3genetic
27708008
MOB2_YEASTMOB2genetic
27708008
SMD1_YEASTSMD1genetic
27708008
HSP77_YEASTSSC1genetic
27708008
NSE1_YEASTNSE1genetic
27708008
TAD3_YEASTTAD3genetic
27708008
ERB1_YEASTERB1genetic
27708008
CBF3B_YEASTCEP3genetic
27708008
NTH1_YEASTNTG1genetic
27708008
HIR1_YEASTHIR1genetic
27708008
ETR1_YEASTETR1genetic
27708008
STE50_YEASTSTE50genetic
27708008
YCQ6_YEASTYCR016Wgenetic
27708008
RS29B_YEASTRPS29Bgenetic
27708008
BAP3_YEASTBAP3genetic
27708008
ATC5_YEASTDNF1genetic
27708008
YGY5_YEASTYGL235Wgenetic
27708008
ADH4_YEASTADH4genetic
27708008
YG1X_YEASTYGR050Cgenetic
27708008
RL8A_YEASTRPL8Agenetic
27708008
PIH1_YEASTPIH1genetic
27708008
SOL3_YEASTSOL3genetic
27708008
AIM18_YEASTAIM18genetic
27708008
HOS4_YEASTHOS4genetic
27708008
DHOM_YEASTHOM6genetic
27708008
KDX1_YEASTKDX1genetic
27708008
SAC1_YEASTSAC1genetic
27708008
RL37A_YEASTRPL37Agenetic
27708008
MMS22_YEASTMMS22genetic
27708008
COX8_YEASTCOX8genetic
27708008
SEI1_YEASTFLD1genetic
27708008
DUS4_YEASTDUS4genetic
27708008
RS3A1_YEASTRPS1Agenetic
27708008
MAC1_YEASTMAC1genetic
27708008
AEP2_YEASTAEP2genetic
27708008
HRB1_YEASTHRB1genetic
27708008
MKS1_YEASTMKS1genetic
27708008
MKT1_YEASTMKT1genetic
27708008
NST1_YEASTNST1genetic
27708008
MIC27_YEASTMIC27genetic
27708008
DIA2_YEASTDIA2genetic
27708008
WHI5_YEASTWHI5genetic
27708008
DGK1_YEASTDGK1genetic
27708008
IML3_YEASTIML3genetic
27708008
CS111_YEASTCOS111genetic
27708008
BUD31_YEASTBUD31genetic
27708008
ERS1_YEASTERS1genetic
27708008
PP2C1_YEASTPTC1genetic
27708008
SLX5_YEASTSLX5genetic
27708008
RL13A_YEASTRPL13Agenetic
27708008
VPS41_YEASTVPS41genetic
27708008
UME6_YEASTUME6genetic
27708008
MNN10_YEASTMNN10genetic
27708008
APT2_YEASTAPT2genetic
27708008
SLX8_YEASTSLX8genetic
27708008
RAD4_YEASTRAD4genetic
27708008
MSH4_YEASTMSH4genetic
27708008
TFS2_YEASTDST1genetic
27708008
XRN1_YEASTXRN1genetic
27708008
YGZ2_YEASTYGL242Cgenetic
27708008
RME1_YEASTRME1genetic
27708008
MAL12_YEASTMAL12genetic
27708008
OPI1_YEASTOPI1genetic
27708008
HTD2_YEASTHTD2genetic
27708008
SNL1_YEASTSNL1genetic
27708008
SDS3_YEASTSDS3genetic
27708008
NCA3_YEASTNCA3genetic
27708008
RPA34_YEASTRPA34genetic
27708008
BFA1_YEASTBFA1genetic
27708008
CSN12_YEASTYJR084Wgenetic
27708008
UBL1_YEASTYUH1genetic
27708008
YJ90_YEASTYJR120Wgenetic
27708008
MCR1_YEASTMCR1genetic
27708008
ELF1_YEASTELF1genetic
27708008
RL8B_YEASTRPL8Bgenetic
27708008
PUR91_YEASTADE16genetic
27708008
ENT2_YEASTENT2genetic
27708008
ARV1_YEASTARV1genetic
27708008
EFM7_YEASTNNT1genetic
27708008
VID22_YEASTVID22genetic
27708008
AIM32_YEASTAIM32genetic
27708008
LSM7_YEASTLSM7genetic
27708008
ATG3_YEASTATG3genetic
27708008
BRE5_YEASTBRE5genetic
27708008
PMT3_YEASTPMT3genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of IDI1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7, AND MASSSPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-24, AND MASSSPECTROMETRY.

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