SEF1_YEAST - dbPTM
SEF1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SEF1_YEAST
UniProt AC P34228
Protein Name Putative transcription factor SEF1
Gene Name SEF1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1148
Subcellular Localization Nucleus .
Protein Description Putative transcription factor that seems to be involved in the sporulation process. Suppresses the lethal phenotype of RPM2 deletion..
Protein Sequence MVKDNRDSDQDQDFSSAHMKRQPEQQQLQQHQFPSKKQRISHHDDSHQINHRPVTSCTHCRQHKIKCDASQNFPHPCSRCEKIGLHCEINPQFRPKKGSQLQLLRQDVDEIKSKLDTLLANDSVFVHLLQQIPMGNSLLNKLNLHPTPTPGTIIPNPDSSPSSGSPTSSAAQRDSKVSVQTYLSREPQLLQANQGSNTNKFKANNEASSHMTLRASSLAQDSKGLVATEPNKLPPLLNDSALPNNSKESLPPALQMAFYKNNSAGNTPNGPFSPIQKTYSPHTTSTTVTTTTNQPPFAATSHVATNNNADRTKTPVVATTTTMPLLPSPHANVDEFVLGDISISIEKANRLHHIFVTRYLPYFPIMYSNNATELYSQSQLLFWTVMLTACLSDPEPTMYCKLSSLIKQLAIETCWIRTPRSTHISQALLILCIWPLPNQKVLDDCSYRFVGLAKSLSYQLGLHRGEFISEFTRTQTSMPNAEKWRTRTWLGIFFAELCWASILGLPPTSQTDYLLEKALSCGDEESEEDNNDSIDNNNNDKRNKKDEPHVESKYKLPGSFRRLLSLANFQAKLSHIIGSSTSSPDGLLEPKYRAETLSILGKELDLLAKTLNFQSDDTVNIYFLYVKLTVCCFAFLPETPPTDQIPYVTEAYLTATKIVTLLNNLLETHQLIELPIYIRQAATFSALILFKLQLTPLLPDKYFDSARQSVVTIHRLYRNQLTAWATSVENDISRTASMLEKLNFVLIMHPEVFVEEDGIISRMRSHLTGSLFYDLVWCVHEARRREMDPEYNKQALEKAAKKRKFSSNGIYNGTSSTGGITDRKLYPLPLYNHISRDDFETVTKTTPSGTTVTTLVPTKNALKQAEKLAKTNNGDSDGSIMEINGIPLSMLGETGSVKFQSLFANTSNSNDYNNNRTLLDASNDISIPSNSIYPVASVPASNNNPQSTKVDYYSNGPSVIPDLSMKRSVSTPVNHFPASVPGLRNHPVGNLSNNVTLGIDHPIPREHSNLQNVTMNYNNQFSNANAIGRSQSSMSHSRTPIASKSNNMTDLHSVVSDPGSSKSTAYPPLSLFSKSNDINSNKTNQRFSTGTNTVTSSNFQTIDNENNVKTPGNKLTDFFQQQSAGWIEGNSSNDDFFGWFDMNMEQGF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
8PhosphorylationMVKDNRDSDQDQDFS
CCCCCCCCCCCCCCH		33.6522369663
15PhosphorylationSDQDQDFSSAHMKRQ
CCCCCCCHHHHHHHC		34.6022369663
16PhosphorylationDQDQDFSSAHMKRQP
CCCCCCHHHHHHHCH		23.3722369663
147PhosphorylationNKLNLHPTPTPGTII
HHCCCCCCCCCCCCC		29.1019823750
149PhosphorylationLNLHPTPTPGTIIPN
CCCCCCCCCCCCCCC		36.5119823750
152PhosphorylationHPTPTPGTIIPNPDS
CCCCCCCCCCCCCCC		19.5519823750
159PhosphorylationTIIPNPDSSPSSGSP
CCCCCCCCCCCCCCC		45.4621440633
160PhosphorylationIIPNPDSSPSSGSPT
CCCCCCCCCCCCCCC		35.8628152593
162PhosphorylationPNPDSSPSSGSPTSS
CCCCCCCCCCCCCCC		49.6419823750
163PhosphorylationNPDSSPSSGSPTSSA
CCCCCCCCCCCCCCH		46.8325752575
165PhosphorylationDSSPSSGSPTSSAAQ
CCCCCCCCCCCCHHH		27.2719823750
167PhosphorylationSPSSGSPTSSAAQRD
CCCCCCCCCCHHHHC		36.6921440633
168PhosphorylationPSSGSPTSSAAQRDS
CCCCCCCCCHHHHCC		22.7423749301
169PhosphorylationSSGSPTSSAAQRDSK
CCCCCCCCHHHHCCC		30.0619823750
175PhosphorylationSSAAQRDSKVSVQTY
CCHHHHCCCCCHHHH		36.8321440633
184PhosphorylationVSVQTYLSREPQLLQ
CCHHHHHCCCHHHHH		24.9627017623
196PhosphorylationLLQANQGSNTNKFKA
HHHCCCCCCCCCCCC		30.6227017623
209PhosphorylationKANNEASSHMTLRAS
CCCCCHHHCCHHHHH		25.0721440633
212PhosphorylationNEASSHMTLRASSLA
CCHHHCCHHHHHHHH		13.9928889911
216PhosphorylationSHMTLRASSLAQDSK
HCCHHHHHHHHHCCC		21.3221440633
217PhosphorylationHMTLRASSLAQDSKG
CCHHHHHHHHHCCCC		27.0925752575
263PhosphorylationMAFYKNNSAGNTPNG
HHHHCCCCCCCCCCC		47.1221551504
267PhosphorylationKNNSAGNTPNGPFSP
CCCCCCCCCCCCCCC		19.7421440633
273PhosphorylationNTPNGPFSPIQKTYS
CCCCCCCCCCCCCCC		24.9928152593
278PhosphorylationPFSPIQKTYSPHTTS
CCCCCCCCCCCCCCE		16.9221440633
280PhosphorylationSPIQKTYSPHTTSTT
CCCCCCCCCCCCEEE		18.5521440633
328PhosphorylationTTMPLLPSPHANVDE
CCCCCCCCCCCCCCE		29.3228889911
526PhosphorylationLSCGDEESEEDNNDS
HHCCCCCCCCCCCCC		44.2123749301
533PhosphorylationSEEDNNDSIDNNNND
CCCCCCCCCCCCCCC		33.6823749301
806PhosphorylationAAKKRKFSSNGIYNG
HHHHCCCCCCCCCCC		26.4023749301
807PhosphorylationAKKRKFSSNGIYNGT
HHHCCCCCCCCCCCC		42.0619779198
811PhosphorylationKFSSNGIYNGTSSTG
CCCCCCCCCCCCCCC		14.6721440633
814PhosphorylationSNGIYNGTSSTGGIT
CCCCCCCCCCCCCCC		18.8319779198
817PhosphorylationIYNGTSSTGGITDRK
CCCCCCCCCCCCCCC		38.9128889911
821PhosphorylationTSSTGGITDRKLYPL
CCCCCCCCCCCEEEC		32.7827017623
835PhosphorylationLPLYNHISRDDFETV
CCCCCCCCHHHCCCC		23.3126447709
841PhosphorylationISRDDFETVTKTTPS
CCHHHCCCCEEECCC		33.2122369663
843PhosphorylationRDDFETVTKTTPSGT
HHHCCCCEEECCCCC		30.0522369663
845PhosphorylationDFETVTKTTPSGTTV
HCCCCEEECCCCCEE		34.2822369663
846PhosphorylationFETVTKTTPSGTTVT
CCCCEEECCCCCEEE		19.6022369663
848PhosphorylationTVTKTTPSGTTVTTL
CCEEECCCCCEEEEE		46.8322369663
850PhosphorylationTKTTPSGTTVTTLVP
EEECCCCCEEEEEEE		23.5622369663
851PhosphorylationKTTPSGTTVTTLVPT
EECCCCCEEEEEEEC		21.2722369663
853PhosphorylationTPSGTTVTTLVPTKN
CCCCCEEEEEEECHH		16.6022369663
854PhosphorylationPSGTTVTTLVPTKNA
CCCCEEEEEEECHHH		22.7922369663
858PhosphorylationTVTTLVPTKNALKQA
EEEEEEECHHHHHHH		29.4722369663
968PhosphorylationPDLSMKRSVSTPVNH
CCCCCCCCCCCCCCC		18.2022369663
970PhosphorylationLSMKRSVSTPVNHFP
CCCCCCCCCCCCCCC		28.3922369663
971PhosphorylationSMKRSVSTPVNHFPA
CCCCCCCCCCCCCCC		29.1522369663
979PhosphorylationPVNHFPASVPGLRNH
CCCCCCCCCCCCCCC		29.1426447709
1008PhosphorylationHPIPREHSNLQNVTM
CCCCCCCCCCCCCCC		34.1922369663
1014PhosphorylationHSNLQNVTMNYNNQF
CCCCCCCCCCCCCCC		13.7722369663
1017PhosphorylationLQNVTMNYNNQFSNA
CCCCCCCCCCCCCCC		12.5022369663
1022PhosphorylationMNYNNQFSNANAIGR
CCCCCCCCCCCCCCC		25.8522369663
1032PhosphorylationNAIGRSQSSMSHSRT
CCCCCCCCCCCCCCC		29.2929136822
1033PhosphorylationAIGRSQSSMSHSRTP
CCCCCCCCCCCCCCC		19.3730377154
1035PhosphorylationGRSQSSMSHSRTPIA
CCCCCCCCCCCCCCC		21.9129136822
1037PhosphorylationSQSSMSHSRTPIASK
CCCCCCCCCCCCCCC		30.4629136822
1039PhosphorylationSSMSHSRTPIASKSN
CCCCCCCCCCCCCCC		23.2829136822
1043PhosphorylationHSRTPIASKSNNMTD
CCCCCCCCCCCCCCC		37.0229136822
1045PhosphorylationRTPIASKSNNMTDLH
CCCCCCCCCCCCCHH		30.8229136822
1049PhosphorylationASKSNNMTDLHSVVS
CCCCCCCCCHHHCCC		37.2224961812
1053PhosphorylationNNMTDLHSVVSDPGS
CCCCCHHHCCCCCCC		31.3523749301
1056PhosphorylationTDLHSVVSDPGSSKS
CCHHHCCCCCCCCCC		35.6122369663
1060PhosphorylationSVVSDPGSSKSTAYP
HCCCCCCCCCCCCCC		39.7322369663
1061PhosphorylationVVSDPGSSKSTAYPP
CCCCCCCCCCCCCCC		36.2222369663
1110PhosphorylationDNENNVKTPGNKLTD
CCCCCCCCCCCHHHH		31.9525752575
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SEF1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SEF1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SEF1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SIN3_YEASTSIN3genetic
20959818
AATC_YEASTAAT2genetic
20959818
YAP8_YEASTARR1genetic
20959818
STP2_YEASTSTP2genetic
20959818
HAP4_YEASTHAP4genetic
20959818
HAP3_YEASTHAP3genetic
20959818
ACA2_YEASTCST6genetic
20959818
GAL3_YEASTGAL3genetic
20959818
SNT1_YEASTSNT1genetic
20959818
AP1_YEASTYAP1genetic
20959818
RPA14_YEASTRPA14genetic
20959818
YFF2_YEASTYFL052Wgenetic
20959818
HAP5_YEASTHAP5genetic
20959818
PFD3_YEASTPAC10genetic
20959818
TXTP_YEASTCTP1genetic
27708008
NHP10_YEASTNHP10genetic
27708008
GPR1_YEASTGPR1genetic
27708008
IDHP_YEASTIDP1genetic
27708008
ARO1_YEASTARO1genetic
27708008
RPA14_YEASTRPA14genetic
27708008
DOT1_YEASTDOT1genetic
27708008
SLX8_YEASTSLX8genetic
27708008
ERV14_YEASTERV14genetic
27708008
DPH1_YEASTDPH1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SEF1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-163; SER-165; SER-263;SER-328; THR-845; THR-846; SER-848; SER-968 AND SER-970, AND MASSSPECTROMETRY.

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