STP2_YEAST - dbPTM
STP2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID STP2_YEAST
UniProt AC P38704
Protein Name Transcription factor STP2
Gene Name STP2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 541
Subcellular Localization Cell membrane
Peripheral membrane protein
Cytoplasmic side. Nucleus . Localizes to the cytoplasm in its unprocessed form and is targeted to the nucleus after proteolytic processing upon induction by amino acids.
Protein Description Transcription factor involved in the regulation of gene expression in response to extracellular amino acid levels. Synthesized as latent cytoplasmic precursor, which, upon a signal initiated by the plasma membrane SPS (SSY1-PTR3-SSY5) amino acid sensor system, becomes proteolytically activated and relocates to the nucleus, where it induces the expression of SPS-sensor-regulated genes, including the amino-acid permeases BAP2 and BAP3. Binding to promoters is facilitated by DAL81 (By similarity). Involved in the repression of genes subject to nitrogen catabolite repression and genes involved in stress response. Negatively regulated by inner nuclear membrane proteins ASI1, ASI2 and ASI3, which prevent unprocessed precursor forms that escape cytoplasmic anchoring from inducing SPS-sensor-regulated genes..
Protein Sequence MPILSLSSTRNSVLTRIYDYLKALVQQVIVPNVEDDKSSKSTPFEKLEPAKQNHPQKDCCATEKDDLVDVSELFPKQNNKQLSLTSKSSVVPCALNLDNLETPFSIKIDNNGAVTTQLNLDEPILRGPSRGEPAKLQNDLISSPPLEESYINNDQYKALFPSNFLPITPVSSVITPASKKSIDESPLSDEVQGIADESSETLPYICHYCDARFRIRGYLTRHIKKHAKRKAYHCPFFDNSISQELRCHTSGGFSRRDTYKTHLKSRHFTYPEGVKPQDRNKSPGVCTQCGEHFSTSESWVENHIEAGSCKGLPEGYSEGIREKKKTSKMKMIKTSDGQTRFISSDESVSEPALQNKNCIEATVMQSKERPNDKIIPTKTEKNDFGIGTQWFERKQISRPTQTTQSRGPTEVQNLKEWSIISPPILSPQNASSVPQEYQSSRYTLHMDSPALSSASSALSPLSGDPITTTETNKSYPLDSEQSLLEPDKTEEDAINQSKESNMISINEMLQKQMDFELLGENHLKETQDYLALYKKAYGIEF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
22UbiquitinationTRIYDYLKALVQQVI
HHHHHHHHHHHHHHC		33.1817644757
37UbiquitinationVPNVEDDKSSKSTPF
CCCCCCCCCCCCCCH		69.7917644757
40UbiquitinationVEDDKSSKSTPFEKL
CCCCCCCCCCCHHHC		66.4917644757
87UbiquitinationKQLSLTSKSSVVPCA
CCCEECCCCCCCEEE		41.3317644757
107UbiquitinationLETPFSIKIDNNGAV
CCCCEEEEECCCCCE		42.6917644757
115PhosphorylationIDNNGAVTTQLNLDE
ECCCCCEEEEEECCC		14.3222369663
116PhosphorylationDNNGAVTTQLNLDEP
CCCCCEEEEEECCCC		25.1822369663
129PhosphorylationEPILRGPSRGEPAKL
CCHHHCCCCCCCCCC		56.6022369663
135UbiquitinationPSRGEPAKLQNDLIS
CCCCCCCCCCCCCCC		62.4117644757
142PhosphorylationKLQNDLISSPPLEES
CCCCCCCCCCCCCHH		44.0521440633
143PhosphorylationLQNDLISSPPLEESY
CCCCCCCCCCCCHHH		24.4425752575
149PhosphorylationSSPPLEESYINNDQY
CCCCCCHHHCCCHHH		23.1827017623
157UbiquitinationYINNDQYKALFPSNF
HCCCHHHHHHCCCCC		32.7417644757
168PhosphorylationPSNFLPITPVSSVIT
CCCCCCCCCCCCCCC		18.7221440633
179UbiquitinationSVITPASKKSIDESP
CCCCCCCCCCCCCCC		53.2817644757
180UbiquitinationVITPASKKSIDESPL
CCCCCCCCCCCCCCC		50.5817644757
230UbiquitinationIKKHAKRKAYHCPFF
HHHHHHHHHHCCCCC		53.2217644757
269PhosphorylationHLKSRHFTYPEGVKP
HHHHCCCCCCCCCCC		31.8528889911
275UbiquitinationFTYPEGVKPQDRNKS
CCCCCCCCCCCCCCC		48.0617644757
281UbiquitinationVKPQDRNKSPGVCTQ
CCCCCCCCCCCCCCC		59.9417644757
310UbiquitinationHIEAGSCKGLPEGYS
HHHCCCCCCCCCCCC		66.2417644757
335PhosphorylationKMKMIKTSDGQTRFI
CCEEEECCCCCEEEE		34.4428889911
356UbiquitinationSEPALQNKNCIEATV
CCHHHHCCCCEEHHH		39.9917644757
381UbiquitinationIIPTKTEKNDFGIGT
CCCCCCCCCCCCCCC		68.0317644757
394UbiquitinationGTQWFERKQISRPTQ
CCHHHHHCCCCCCCC		44.8017644757
400PhosphorylationRKQISRPTQTTQSRG
HCCCCCCCCCCCCCC		37.1228889911
415UbiquitinationPTEVQNLKEWSIISP
CCCCCCCCEEEEECC		65.7617644757
448PhosphorylationRYTLHMDSPALSSAS
CCEEECCCHHHHHCH		12.4223749301
459PhosphorylationSSASSALSPLSGDPI
HHCHHHCCCCCCCCC		24.4225752575
474PhosphorylationTTTETNKSYPLDSEQ
CCCCCCCCCCCCCCC		33.7722369663
475PhosphorylationTTETNKSYPLDSEQS
CCCCCCCCCCCCCCC		14.9322369663
479PhosphorylationNKSYPLDSEQSLLEP
CCCCCCCCCCCCCCC		45.2622369663
482PhosphorylationYPLDSEQSLLEPDKT
CCCCCCCCCCCCCCC		30.7621440633
489PhosphorylationSLLEPDKTEEDAINQ
CCCCCCCCHHHHHHH		52.5721440633
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of STP2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of STP2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of STP2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
LCP5_YEASTLCP5genetic
19061648
CAK1_YEASTCAK1genetic
19061648
ELP5_YEASTIKI1genetic
19061648
YAJ9_YEASTYAR029Wgenetic
20093466
SEC66_YEASTSEC66genetic
20093466
MGR1_YEASTMGR1genetic
20093466
SNT1_YEASTSNT1genetic
20093466
THRC_YEASTTHR4genetic
20093466
PCL9_YEASTPCL9genetic
20093466
VMS1_YEASTVMS1genetic
20093466
VPS41_YEASTVPS41genetic
20093466
ARO1_YEASTARO1genetic
20093466
UME6_YEASTUME6genetic
20093466
MTH1_YEASTMTH1genetic
20093466
STP1_YEASTSTP1genetic
20093466
AK_YEASTHOM3genetic
20093466
HAP2_YEASTHAP2genetic
20093466
AIR1_YEASTAIR1genetic
20093466
PIR5_YEASTYJL160Cgenetic
20093466
SRX1_YEASTSRX1genetic
20093466
RL40A_YEASTRPL40Bgenetic
20093466
RL40B_YEASTRPL40Bgenetic
20093466
RIM11_YEASTRIM11genetic
20093466
GCSP_YEASTGCV2genetic
20093466
COX7_YEASTCOX7genetic
20093466
ODP2_YEASTLAT1genetic
20093466
INO4_YEASTINO4genetic
20093466
DFG16_YEASTDFG16genetic
20093466
SPT8_YEASTSPT8genetic
20959818
SGF73_YEASTSGF73genetic
20959818
SAC3_YEASTSAC3genetic
20959818
IES4_YEASTIES4genetic
20959818
SUB1_YEASTSUB1genetic
20959818
UBP3_YEASTUBP3genetic
20959818
PACC_YEASTRIM101genetic
21127252
RIM11_YEASTRIM11genetic
22282571
MBA1_YEASTMBA1genetic
27708008
PALA_YEASTRIM20genetic
27708008
YAJ9_YEASTYAR029Wgenetic
27708008
HAP3_YEASTHAP3genetic
27708008
SEC66_YEASTSEC66genetic
27708008
MGR1_YEASTMGR1genetic
27708008
SNT1_YEASTSNT1genetic
27708008
PBP4_YEASTPBP4genetic
27708008
HOSM_YEASTLYS21genetic
27708008
SRF1_YEASTSRF1genetic
27708008
PCL9_YEASTPCL9genetic
27708008
VMS1_YEASTVMS1genetic
27708008
UME6_YEASTUME6genetic
27708008
MTH1_YEASTMTH1genetic
27708008
STP1_YEASTSTP1genetic
27708008
MPC1_YEASTMPC1genetic
27708008
PTH_YEASTPTH1genetic
27708008
URM1_YEASTURM1genetic
27708008
AIR1_YEASTAIR1genetic
27708008
FMC1_YEASTFMC1genetic
27708008
SDHX_YEASTYJL045Wgenetic
27708008
MRX5_YEASTYJL147Cgenetic
27708008
PIR5_YEASTYJL160Cgenetic
27708008
YJ09_YEASTYJR039Wgenetic
27708008
MET5_YEASTMET5genetic
27708008
SRX1_YEASTSRX1genetic
27708008
RL40A_YEASTRPL40Bgenetic
27708008
RL40B_YEASTRPL40Bgenetic
27708008
CMS1_YEASTCMS1genetic
27708008
COX12_YEASTCOX12genetic
27708008
IMH1_YEASTIMH1genetic
27708008
RIM11_YEASTRIM11genetic
27708008
GCSP_YEASTGCV2genetic
27708008
COX7_YEASTCOX7genetic
27708008
BRE5_YEASTBRE5genetic
27708008
INO4_YEASTINO4genetic
27708008
COX10_YEASTCOX10genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of STP2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-143 AND SER-459, ANDMASS SPECTROMETRY.

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