RIM11_YEAST - dbPTM
RIM11_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RIM11_YEAST
UniProt AC P38615
Protein Name Serine/threonine-protein kinase RIM11/MSD1
Gene Name RIM11
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 370
Subcellular Localization
Protein Description Serine/threonine protein kinase that is thought to function in regulating kinetochore activity and entry into meiosis. Could phosphorylates IME1..
Protein Sequence MNIQSNNSPNLSNNIVSKQVYYAHPPPTIDPNDPVQISFPTTEVVGHGSFGVVFATVIQETNEKVAIKKVLQDKRFKNRELEIMKMLSHINIIDLKYFFYERDSQDEIYLNLILEYMPQSLYQRLRHFVHQRTPMSRLEIKYYMFQLFKSLNYLHHFANVCHRDIKPQNLLVDPETWSLKLCDFGSAKQLKPTEPNVSYICSRYYRAPELIFGATNYTNQIDIWSSGCVMAELLLGQPMFPGESGIDQLVEIIKILGTPSKQEICSMNPNYMEHKFPQIKPIPLSRVFKKEDDQTVEFLADVLKYDPLERFNALQCLCSPYFDELKLDDGKINQITTDLKLLEFDENVELGHLSPDELSSVKKKLYPKSK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
5Phosphorylation---MNIQSNNSPNLS
---CCCCCCCCCCCC		33.8924909858
8PhosphorylationMNIQSNNSPNLSNNI
CCCCCCCCCCCCCCC		21.2922369663
12PhosphorylationSNNSPNLSNNIVSKQ
CCCCCCCCCCCCEEE		34.1822369663
17PhosphorylationNLSNNIVSKQVYYAH
CCCCCCCEEEEEECC		17.3622369663
193PhosphorylationSAKQLKPTEPNVSYI
CCCCCCCCCCCHHHH		63.5922890988
198PhosphorylationKPTEPNVSYICSRYY
CCCCCCHHHHHHHHH		18.5422369663
199PhosphorylationPTEPNVSYICSRYYR
CCCCCHHHHHHHHHC		11.1522369663
202PhosphorylationPNVSYICSRYYRAPE
CCHHHHHHHHHCCCH		17.4822890988
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RIM11_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RIM11_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RIM11_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
NAP1_YEASTNAP1physical
11805826
KPR5_YEASTPRS5physical
11805837
MYO4_YEASTMYO4physical
11805837
MYO2_YEASTMYO2physical
11805837
NAP1_YEASTNAP1physical
11805837
GIN4_YEASTGIN4physical
11805837
IRA1_YEASTIRA1physical
11805837
GCR2_YEASTGCR2physical
11805837
YE11B_YEASTYER138Cphysical
11805837
CDC25_YEASTCDC25physical
11805837
KICH_YEASTCKI1physical
11805837
KPR3_YEASTPRS3physical
11805837
YE12B_YEASTYER160Cphysical
11805837
YJ11B_YEASTYJR027Wphysical
11805837
YJ12A_YEASTYJR028Wphysical
11805837
TPS1_YEASTTPS1physical
11805837
PMD1_YEASTPMD1physical
11805837
KPR2_YEASTPRS2physical
11805837
IRA2_YEASTIRA2physical
11805837
YD17A_YEASTYDR170W-Aphysical
11805837
AK_YEASTHOM3physical
11805837
TSL1_YEASTTSL1physical
11805837
IME1_YEASTIME1physical
10688190
IME1_YEASTIME1physical
10545448
UME6_YEASTUME6physical
9372955
IME1_YEASTIME1physical
9111339
IME1_YEASTIME1physical
7969131
STE50_YEASTSTE50physical
14555477
MSN2_YEASTMSN2genetic
12529445
MRK1_YEASTMRK1genetic
12529445
YGK3_YEASTYGK3genetic
12529445
ROG1_YEASTROG1genetic
10958669
GIN4_YEASTGIN4physical
16554755
NAP1_YEASTNAP1physical
16554755
PFKA2_YEASTPFK2physical
16319894
MGA1_YEASTMGA1physical
16319894
UME6_YEASTUME6physical
16319894
HPH2_YEASTFRT2physical
16319894
SEC2_YEASTSEC2physical
16319894
MBR1_YEASTMBR1physical
16319894
ALY2_YEASTALY2physical
16319894
MIG1_YEASTMIG1physical
16319894
GYS2_YEASTGSY2physical
16319894
YP077_YEASTYPL077Cphysical
16319894
AIM39_YEASTAIM39physical
16319894
TDA1_YEASTTDA1physical
16319894
RCN1_YEASTRCN1physical
16319894
6P21_YEASTPFK26physical
16319894
PAH1_YEASTPAH1physical
16319894
VHS2_YEASTVHS2physical
16319894
UBX7_YEASTUBX7physical
16319894
IME1_YEASTIME1physical
11283351
PGM1_YEASTPGM1genetic
12529445
RIM11_YEASTRIM11physical
18467557
KPR2_YEASTPRS2physical
19754463
KPR3_YEASTPRS3physical
19754463
KPR5_YEASTPRS5physical
19754463
ALG3_YEASTALG3genetic
20093466
CSN9_YEASTCSN9genetic
20093466
HXKB_YEASTHXK2genetic
20093466
VMA21_YEASTVMA21genetic
20093466
STP2_YEASTSTP2genetic
20093466
LPLA_YEASTAIM22genetic
20093466
SUT2_YEASTSUT2genetic
20093466
GCR2_YEASTGCR2physical
20489023
GIN4_YEASTGIN4physical
20489023
GLN3_YEASTGLN3physical
20489023
KCC4_YEASTKCC4physical
20489023
NAP1_YEASTNAP1physical
20489023
PMD1_YEASTPMD1physical
20489023
IF4F2_YEASTTIF4632physical
20489023
UME6_YEASTUME6physical
20489023
YJ12B_YEASTYJR029Wphysical
20489023
MCK1_YEASTMCK1genetic
10958669
NAT5_YEASTNAT5genetic
10958669
SDS22_YEASTSDS22physical
21460040
TDA1_YEASTTDA1physical
21460040
YI31B_YEASTYIL082W-Aphysical
21460040
YHP1_YEASTYHP1genetic
21127252
BCK1_YEASTBCK1genetic
21127252
REI1_YEASTREI1genetic
21127252
PP4R2_YEASTPSY4genetic
21127252
MET18_YEASTMET18genetic
21127252
GAL80_YEASTGAL80genetic
21127252
FUS3_YEASTFUS3genetic
21127252
RIM11_YEASTRIM11physical
22615397
MED3_YEASTPGD1genetic
22282571
ALG3_YEASTALG3genetic
22282571
CSN9_YEASTCSN9genetic
22282571
VMA21_YEASTVMA21genetic
22282571
ROG3_YEASTROG3genetic
12163175
VMA21_YEASTVMA21genetic
27708008
ALG3_YEASTALG3genetic
27708008
SNT1_YEASTSNT1genetic
27708008
SNF6_YEASTSNF6genetic
27708008
SIN3_YEASTSIN3genetic
28468907
RPD3_YEASTRPD3genetic
28468907
RAD52_YEASTRAD52genetic
28468907
RAD59_YEASTRAD59genetic
28468907
DCOR_YEASTSPE1genetic
27453043
RPB3_YEASTRPB3genetic
27453043
VPS75_YEASTVPS75genetic
27453043
GCR2_YEASTGCR2genetic
27453043
FLX1_YEASTFLX1genetic
27453043
BUB1_YEASTBUB1genetic
27453043
AAKG_YEASTSNF4genetic
27453043
DCAM_YEASTSPE2genetic
27453043
SSN3_YEASTSSN3genetic
27453043
VPS53_YEASTVPS53genetic
27453043
IRA2_YEASTIRA2genetic
27453043
CBF1_YEASTCBF1genetic
27453043
SCH9_YEASTSCH9genetic
27453043
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RIM11_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-8 AND TYR-199, AND MASSSPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-198, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-199, AND MASSSPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-199, AND MASSSPECTROMETRY.
"Essential functions of protein tyrosine phosphatases PTP2 and PTP3and RIM11 tyrosine phosphorylation in Saccharomyces cerevisiae meiosisand sporulation.";
Zhan X.L., Hong Y., Zhu T., Mitchell A.P., Deschenes R.J., Guan K.L.;
Mol. Biol. Cell 11:663-676(2000).
Cited for: PHOSPHORYLATION AT TYR-199.

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