dbPTM

YGK3_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	YGK3_YEAST
UniProt AC	Q12222
Protein Name	Glycogen synthase kinase-3 homolog YGK3
Gene Name	YGK3
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	375
Subcellular Localization
Protein Description	Required for heat stress-instigated phosphorylation of BCY1 which is involved in cell wall integrity signaling. Regulates activity of MSN2, a transcription factor that binds to the stress-response element (STRE). Probably promotes formation of a complex between MSN2 and DNA. Regulates the stability of ROG1..
Protein Sequence	MLKVNNVFGSNPNRMTKLEDEHYFIDDIVSIKNRQKSKMYVREGKRIGHGSFGTVTQSILSSNSIEWLGPYAIKRVVKSPKVQSLELEILQNIRHPNLVTLEFFFESHCTTKDGGHLYQKNFVMEYIPQTLSSEIHEYFDNGSKMPTKHIKLYTFQILRALLTLHSMSICHGDLKPSNILIIPSSGIAKVCDFGSAQRLDDNTELKTYFCSRFYRAPELLLNSKDYTTQIDIWSLGCIIGEMIKGQPLFKGDSANSQLEEIAKLLGRFPKSSIKNSQELQDSLNDQKFKKFMHWFPSIEFFDVEFLLKVLTYDATERCDARQLMAHEFFDALRNETYFLPRGSSMPVHLPDLFNFSASEKRALGEYYNLIVPSLD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
208	Phosphorylation	DNTELKTYFCSRFYR CCHHHHHHHHHHHHC	10.86	20377248
211	Phosphorylation	ELKTYFCSRFYRAPE HHHHHHHHHHHCCHH	18.61	17287358
276	Phosphorylation	PKSSIKNSQELQDSL CHHHCCCHHHHHHHH	21.74	28889911
282	Phosphorylation	NSQELQDSLNDQKFK CHHHHHHHHCHHHHH	18.99	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of YGK3_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of YGK3_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of YGK3_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GSP2_YEAST	GSP2	physical	11805837
TRXB1_YEAST	TRR1	physical	11805837
OYE2_YEAST	OYE2	physical	11805837
MDHM_YEAST	MDH1	physical	11805837
MSN2_YEAST	MSN2	genetic	12529445
MCK1_YEAST	MCK1	genetic	12529445
KAPR_YEAST	BCY1	physical	16319894
KCC2_YEAST	CMK2	physical	16319894
CYSD_YEAST	MET17	physical	16319894
RHO4_YEAST	RHO4	physical	16319894
PTK2_YEAST	PTK2	physical	16319894
PGM1_YEAST	PGM1	genetic	12529445
KHSE_YEAST	THR1	genetic	19269370
SKI7_YEAST	SKI7	genetic	19269370
EI2BE_YEAST	GCD6	physical	20489023
LSM12_YEAST	LSM12	physical	20489023
MTC1_YEAST	MTC1	physical	20489023
PUF3_YEAST	PUF3	physical	20489023
METK1_YEAST	SAM1	physical	20489023
SPT16_YEAST	SPT16	physical	20489023
SYPM_YEAST	AIM10	physical	21460040
IF5A2_YEAST	ANB1	physical	21460040
ARA2_YEAST	ARA2	physical	21460040
CARB_YEAST	CPA2	physical	21460040
CRZ1_YEAST	CRZ1	physical	21460040
GLRX4_YEAST	GRX4	physical	21460040
GYS2_YEAST	GSY2	physical	21460040
NTF2_YEAST	NTF2	physical	21460040
KPR1_YEAST	PRS1	physical	21460040
RIM11_YEAST	RIM11	physical	21460040
UBX1_YEAST	SHP1	physical	21460040
YIG1_YEAST	YIG1	physical	21460040
CG11_YEAST	CLN1	genetic	21127252
REI1_YEAST	REI1	genetic	21127252
MET18_YEAST	MET18	genetic	21127252
MMS22_YEAST	MMS22	genetic	21127252
MET32_YEAST	MET32	genetic	21127252

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of YGK3_YEAST

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-211, AND MASSSPECTROMETRY.	17287358 [Abstract]
"A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-208, AND MASSSPECTROMETRY.	18407956 [Abstract]