CARB_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CARB_YEAST
• UniProt AC: P03965
• Protein Name: Carbamoyl-phosphate synthase arginine-specific large chain
• Gene Name: CPA2
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 1118
• Subcellular Localization: Cytoplasm.
• Protein Sequence: MTSIYTSTEPTNSAFTTEDYKPQLVEGVNSVLVIGSGGLSIGQAGEFDYSGSQAIKALKEDNKFTILVNPNIATNQTSHSLADKIYYLPVTPEYITYIIELERPDAILLTFGGQTGLNCGVALDESGVLAKYNVKVLGTPIKTLITSEDRDLFASALKDINIPIAESFACETVDEALEAAERVKYPVIVRSAYALGGLGSGFANNASEMKELAAQSLSLAPQILVEKSLKGWKEVEYEVVRDRVGNCITVCNMENFDPLGVHTGDSMVFAPSQTLSDEEFHMLRSAAIKIIRHLGVIGECNVQYALQPDGLDYRVIEVNARLSRSSALASKATGYPLAYTAAKIGLGYTLPELPNPITKTTVANFEPSLDYIVAKIPKWDLSKFQYVDRSIGSSMKSVGEVMAIGRNYEEAFQKALRQVDPSLLGFQGSTEFGDQLDEALRTPTDRRVLAIGQALIHENYTVERVNELSKIDKWFLYKCMNIVNIYKELESVKSLSDLSKDLLQRAKKLGFSDKQIAVTINKHASTNINELEIRSLRKTLGIIPFVKRIDTLAAEFPAQTNYLYTTYNATKNDVEFNENGMLVLGSGVYRIGSSVEFDWCAVNTAKTLRDQGKKTIMINYNPETVSTDFDEVDRLYFEELSYERVMDIYELEQSEGCIISVGGQLPQNIALKLYDNGCNIMGTNPNDIDRAENRHKFSSILDSIDVDQPEWSELTSVEEAKLFASKVNYPVLIRPSYVLSGAAMSVVNNEEELKAKLTLASDVSPDHPVVMSKFIEGAQEIDVDAVAYNGNVLVHAISEHVENAGVHSGDASLVLPPQHLSDDVKIALKDIADKVAKAWKITGPFNMQIIKDGEHTLKVIECNIRASRSFPFVSKVLGVNFIEIAVKAFLGGDIVPKPVDLMLNKKYDYVATKVPQFSFTRLAGADPFLGVEMASTGEVASFGRDLIESYWTAIQSTMNFHVPLPPSGILFGGDTSREYLGQVASIVATIGYRIYTTNETTKTYLQEHIKEKNAKVSLIKFPKNDKRKLRELFQEYDIKAVFNLASKRAESTDDVDYIMRRNAIDFAIPLFNEPQTALLFAKCLKAKIAEKIKILESHDVIVPPEVRSWDEFIGFKAY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTSIYTSTE ------CCCEECCCC	34.83	19823750
3	Phosphorylation	-----MTSIYTSTEP -----CCCEECCCCC	26.00	19823750
5	Phosphorylation	---MTSIYTSTEPTN ---CCCEECCCCCCC	8.39	19823750
6	Phosphorylation	--MTSIYTSTEPTNS --CCCEECCCCCCCC	27.74	19823750
7	Phosphorylation	-MTSIYTSTEPTNSA -CCCEECCCCCCCCC	17.50	19823750
8	Phosphorylation	MTSIYTSTEPTNSAF CCCEECCCCCCCCCC	37.88	19823750
11	Phosphorylation	IYTSTEPTNSAFTTE EECCCCCCCCCCCCC	35.26	19823750
13	Phosphorylation	TSTEPTNSAFTTEDY CCCCCCCCCCCCCCC	27.51	19823750
16	Phosphorylation	EPTNSAFTTEDYKPQ CCCCCCCCCCCCCCH	29.06	19823750
17	Phosphorylation	PTNSAFTTEDYKPQL CCCCCCCCCCCCCHH	22.02	19823750
20	Phosphorylation	SAFTTEDYKPQLVEG CCCCCCCCCCHHCCC	20.52	19823750
65	Phosphorylation	LKEDNKFTILVNPNI HHHCCCEEEEECCCC	18.27	22369663
74	Phosphorylation	LVNPNIATNQTSHSL EECCCCCCCCCCCCC	24.86	22369663
77	Phosphorylation	PNIATNQTSHSLADK CCCCCCCCCCCCCCC	30.40	22369663
78	Phosphorylation	NIATNQTSHSLADKI CCCCCCCCCCCCCCE	11.00	22369663
80	Phosphorylation	ATNQTSHSLADKIYY CCCCCCCCCCCCEEE	25.64	22369663
135	Acetylation	VLAKYNVKVLGTPIK CEEEEEEEECCCCEE	28.27	22865919
142	Ubiquitination	KVLGTPIKTLITSED EECCCCEEEEECCCC	38.18	15699485
158	Ubiquitination	DLFASALKDINIPIA HHHHHHHHHCCCCHH	57.17	15699485
184	Acetylation	LEAAERVKYPVIVRS HHHHHHCCCCEEEEE	50.48	24489116
210	Ubiquitination	ANNASEMKELAAQSL CCCHHHHHHHHHHHC	45.59	15699485
227	Ubiquitination	APQILVEKSLKGWKE HHHHHHHHHCCCCEE	54.32	15699485
227	Acetylation	APQILVEKSLKGWKE HHHHHHHHHCCCCEE	54.32	24489116
230	Ubiquitination	ILVEKSLKGWKEVEY HHHHHHCCCCEEEEE	70.58	15699485
233	Ubiquitination	EKSLKGWKEVEYEVV HHHCCCCEEEEEEEH	61.63	15699485
233	Acetylation	EKSLKGWKEVEYEVV HHHCCCCEEEEEEEH	61.63	24489116
331	Ubiquitination	RSSALASKATGYPLA HHHHHHHHHHCCCHH	44.34	23749301
343	Ubiquitination	PLAYTAAKIGLGYTL CHHHHHHHHCCCCCC	34.54	17644757
359	Ubiquitination	ELPNPITKTTVANFE CCCCCCCCCCCCCCC	42.81	17644757
383	Ubiquitination	IPKWDLSKFQYVDRS CCCCCHHHCCEECCC	43.73	23749301
383	Acetylation	IPKWDLSKFQYVDRS CCCCCHHHCCEECCC	43.73	24489116
396	Ubiquitination	RSIGSSMKSVGEVMA CCCCCCCCCHHHHHH	43.89	24961812
397	Phosphorylation	SIGSSMKSVGEVMAI CCCCCCCCHHHHHHH	27.06	21440633
442	Phosphorylation	QLDEALRTPTDRRVL HHHHHHCCCCHHHHH	31.24	24909858
444	Phosphorylation	DEALRTPTDRRVLAI HHHHCCCCHHHHHHH	41.34	24909858
470	Acetylation	ERVNELSKIDKWFLY HCHHHHHHCHHHHHH	68.50	24489116
470	Ubiquitination	ERVNELSKIDKWFLY HCHHHHHHCHHHHHH	68.50	17644757
473	Acetylation	NELSKIDKWFLYKCM HHHHHCHHHHHHHHH	43.23	24489116
493	Acetylation	YKELESVKSLSDLSK HHHHHHCCCHHHHCH	55.76	24489116
500	Acetylation	KSLSDLSKDLLQRAK CCHHHHCHHHHHHHH	60.74	24489116
514	Acetylation	KKLGFSDKQIAVTIN HHCCCCCCEEEEEEE	42.26	24489116
522	Ubiquitination	QIAVTINKHASTNIN EEEEEEECCCCCCCC	36.38	17644757
525	Phosphorylation	VTINKHASTNINELE EEEECCCCCCCCHHH	23.00	22369663
526	Phosphorylation	TINKHASTNINELEI EEECCCCCCCCHHHH	40.68	22369663
547	Acetylation	LGIIPFVKRIDTLAA HCCHHHHCHHHHHHH	43.97	24489116
551	Phosphorylation	PFVKRIDTLAAEFPA HHHCHHHHHHHHCCC	18.87	22369663
593	Phosphorylation	SGVYRIGSSVEFDWC CEEEECCCCEEEEEE	28.92	27017623
674	Phosphorylation	QNIALKLYDNGCNIM CCEEEEECCCCCCCC	13.03	28132839
696	Ubiquitination	DRAENRHKFSSILDS HHHHHHHHHHHHHHH	43.64	17644757
721	Ubiquitination	LTSVEEAKLFASKVN CCCHHHHHHHHHCCC	47.63	17644757
726	Ubiquitination	EAKLFASKVNYPVLI HHHHHHHCCCCCEEE	30.94	15699485
754	Ubiquitination	VNNEEELKAKLTLAS CCCHHHHHHHEEECC	46.91	15699485
756	Ubiquitination	NEEELKAKLTLASDV CHHHHHHHEEECCCC	40.18	23749301
761	Phosphorylation	KAKLTLASDVSPDHP HHHEEECCCCCCCCC	41.48	28889911
764	Phosphorylation	LTLASDVSPDHPVVM EEECCCCCCCCCHHH	29.60	28889911
829	Succinylation	DDVKIALKDIADKVA CCHHHHHHHHHHHHH	37.76	23954790
851	Acetylation	PFNMQIIKDGEHTLK CCCEEEEECCCEEEE	62.40	24489116
897	Acetylation	LGGDIVPKPVDLMLN HCCCCCCCCCHHHCC	46.94	24489116
918	Phosphorylation	ATKVPQFSFTRLAGA EEECCCCCCHHCCCC	22.06	27214570
1002	Ubiquitination	YTTNETTKTYLQEHI EECCCHHHHHHHHHH	42.46	17644757
1002	Acetylation	YTTNETTKTYLQEHI EECCCHHHHHHHHHH	42.46	24489116
1010	Acetylation	TYLQEHIKEKNAKVS HHHHHHHHHCCCEEE	65.62	22865919
1010	Ubiquitination	TYLQEHIKEKNAKVS HHHHHHHHHCCCEEE	65.62	17644757
1012	Ubiquitination	LQEHIKEKNAKVSLI HHHHHHHCCCEEEEE	58.15	17644757
1020	Acetylation	NAKVSLIKFPKNDKR CCEEEEEECCCCCHH	61.99	24489116
1028	Ubiquitination	FPKNDKRKLRELFQE CCCCCHHHHHHHHHH	58.60	15699485
1039	Ubiquitination	LFQEYDIKAVFNLAS HHHHHCHHHHHHHHH	35.28	15699485
1047	Ubiquitination	AVFNLASKRAESTDD HHHHHHHHCCCCCCC	50.44	15699485
1082	Ubiquitination	QTALLFAKCLKAKIA HHHHHHHHHHHHHHH	32.53	15699485
1093	Ubiquitination	AKIAEKIKILESHDV HHHHHHCHHHHHCCC	52.91	23749301

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CARB_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CARB_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CARB_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PYR1_YEAST	URA2	physical	16554755
CARA_YEAST	CPA1	physical	16554755
CARA_YEAST	CPA1	physical	16429126
FAS1_YEAST	FAS1	physical	16429126
THDH_YEAST	ILV1	physical	16429126
MPG1_YEAST	PSA1	physical	16429126
PRS6B_YEAST	RPT3	physical	16429126
GFA1_YEAST	GFA1	physical	16429126
RUVB2_YEAST	RVB2	physical	16429126
MEH1_YEAST	MEH1	genetic	15989961
SLM4_YEAST	SLM4	genetic	15989961
GTR2_YEAST	GTR2	genetic	15989961
CARA_YEAST	CPA1	genetic	24124444
PMP1_YEAST	PMP1	physical	26404137

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.