CARA_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CARA_YEAST
• UniProt AC: P07258
• Protein Name: Carbamoyl-phosphate synthase arginine-specific small chain
• Gene Name: CPA1
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 411
• Subcellular Localization: Cytoplasm.
• Protein Sequence: MSSAATKATFCIQNGPSFEGISFGANKSVAGETVFTTSLVGYPESMTDPSYRGQILVFTQPLIGNYGVPSGEARDEYNLLKYFESPHIHVVGIVVAEYAYQYSHWTAVESLAQWCQREGVAAITGVDTRELVQYLREQGSSLGRITLADHDPVPYVNPMKTNLVAQVTTKKPFHVSALPGKAKANVALIDCGVKENIIRCLVKRGANVTVFPYDYRIQDVASEFDGIFLSNGPGNPELCQATISNVRELLNNPVYDCIPIFGICLGHQLLALASGASTHKLKYGNRAHNIPAMDLTTGQCHITSQNHGYAVDPETLPKDQWKPYFVNLNDKSNEGMIHLQRPIFSTQFHPEAKGGPLDTAILFDKFFDNIEKYQLQSQAKSSISLKVTYSTDKSRLQSINVTKLAKERVLF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Ubiquitination	-MSSAATKATFCIQN -CCCHHCEEEEECCC	40.48	17644757
11	Glutathionylation	AATKATFCIQNGPSF HHCEEEEECCCCCCC	2.44	22833525
27	Ubiquitination	GISFGANKSVAGETV EEEECCCCCCCCCEE	45.86	17644757
81	Ubiquitination	RDEYNLLKYFESPHI CHHHHHHHHHCCCCE	51.57	17644757
124	Phosphorylation	REGVAAITGVDTREL HHCCEEEECCCHHHH	26.82	27214570
160	Ubiquitination	VPYVNPMKTNLVAQV CCCCCCCCCCEEEEE	35.20	17644757
170	Ubiquitination	LVAQVTTKKPFHVSA EEEEEECCCCCEEEE	49.43	17644757
171	Ubiquitination	VAQVTTKKPFHVSAL EEEEECCCCCEEEEC	51.31	17644757
181	Ubiquitination	HVSALPGKAKANVAL EEEECCCCCCCCEEE	44.78	17644757
183	Ubiquitination	SALPGKAKANVALID EECCCCCCCCEEEEE	43.94	17644757
194	Ubiquitination	ALIDCGVKENIIRCL EEEECCCHHHHHHHH	30.26	17644757
203	Ubiquitination	NIIRCLVKRGANVTV HHHHHHHHCCCCEEE	31.97	17644757
203	Acetylation	NIIRCLVKRGANVTV HHHHHHHHCCCCEEE	31.97	24489116
280	Ubiquitination	ASGASTHKLKYGNRA HCCCCCCCCCCCCCC	46.92	17644757
318	Ubiquitination	VDPETLPKDQWKPYF ECCCCCCHHHCEEEE	66.71	17644757
322	Ubiquitination	TLPKDQWKPYFVNLN CCCHHHCEEEEEECC	24.98	17644757
322	Acetylation	TLPKDQWKPYFVNLN CCCHHHCEEEEEECC	24.98	24489116
331	Ubiquitination	YFVNLNDKSNEGMIH EEEECCCCCCCCCEE	54.85	17644757
353	Ubiquitination	TQFHPEAKGGPLDTA CCCCCCCCCCCCCHH	63.84	17644757
365	Ubiquitination	DTAILFDKFFDNIEK CHHHHHHHHHHHHHH	40.37	17644757
372	Ubiquitination	KFFDNIEKYQLQSQA HHHHHHHHHHHHHHC	34.20	17644757
380	Ubiquitination	YQLQSQAKSSISLKV HHHHHHCCCCEEEEE	36.78	17644757
380	Acetylation	YQLQSQAKSSISLKV HHHHHHCCCCEEEEE	36.78	24489116
390	Phosphorylation	ISLKVTYSTDKSRLQ EEEEEEECCCHHHHE	22.29	27717283
391	Phosphorylation	SLKVTYSTDKSRLQS EEEEEECCCHHHHEE	36.71	27717283
403	Acetylation	LQSINVTKLAKERVL HEEEECHHHHHHHHC	42.01	24489116

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CARA_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CARA_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CARA_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CSK2C_YEAST	CKB2	physical	10688190
CARB_YEAST	CPA2	genetic	24124444

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.