| UniProt ID | PRS6B_YEAST | |
|---|---|---|
| UniProt AC | P33298 | |
| Protein Name | 26S proteasome regulatory subunit 6B homolog | |
| Gene Name | RPT3 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 428 | |
| Subcellular Localization | Cytoplasm . Nucleus . | |
| Protein Description | The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).. | |
| Protein Sequence | MEELGIVTPVEKAVEEKPAVKSYASLLAQLNGTVNNNSALSNVNSDIYFKLKKLEKEYELLTLQEDYIKDEQRHLKRELKRAQEEVKRIQSVPLVIGQFLEPIDQNTGIVSSTTGMSYVVRILSTLDRELLKPSMSVALHRHSNALVDILPPDSDSSISVMGENEKPDVTYADVGGLDMQKQEIREAVELPLVQADLYEQIGIDPPRGVLLYGPPGTGKTMLVKAVANSTKAAFIRVNGSEFVHKYLGEGPRMVRDVFRLARENAPSIIFIDEVDSIATKRFDAQTGSDREVQRILIELLTQMDGFDQSTNVKVIMATNRADTLDPALLRPGRLDRKIEFPSLRDRRERRLIFGTIASKMSLAPEADLDSLIIRNDSLSGAVIAAIMQEAGLRAVRKNRYVILQSDLEEAYATQVKTDNTVDKFDFYK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 1 | Acetylation | -------MEELGIVT -------CCCCCCCC | 9.01 | 12504901 | |
| 8 | Phosphorylation | MEELGIVTPVEKAVE CCCCCCCCCHHHHHH | 21.50 | 19823750 | |
| 12 | Ubiquitination | GIVTPVEKAVEEKPA CCCCCHHHHHHCCHH | 58.95 | 17644757 | |
| 17 | Ubiquitination | VEKAVEEKPAVKSYA HHHHHHCCHHHHHHH | 25.44 | 17644757 | |
| 21 | Ubiquitination | VEEKPAVKSYASLLA HHCCHHHHHHHHHHH | 39.60 | 17644757 | |
| 56 | Ubiquitination | FKLKKLEKEYELLTL HHHHHHHHHHHHHHH | 75.84 | 17644757 | |
| 69 | Ubiquitination | TLQEDYIKDEQRHLK HHCHHHHHHHHHHHH | 49.32 | 17644757 | |
| 69 | Acetylation | TLQEDYIKDEQRHLK HHCHHHHHHHHHHHH | 49.32 | 24489116 | |
| 132 | Acetylation | TLDRELLKPSMSVAL HCCHHHHCHHHHHHH | 47.90 | 24489116 | |
| 132 | Ubiquitination | TLDRELLKPSMSVAL HCCHHHHCHHHHHHH | 47.90 | 17644757 | |
| 219 | Ubiquitination | YGPPGTGKTMLVKAV ECCCCCCHHHHHHHH | 30.51 | 22817900 | |
| 224 | Ubiquitination | TGKTMLVKAVANSTK CCHHHHHHHHHCCCC | 32.93 | 23749301 | |
| 231 | Ubiquitination | KAVANSTKAAFIRVN HHHHCCCCEEEEEEC | 37.22 | 23749301 | |
| 245 | Acetylation | NGSEFVHKYLGEGPR CCHHHHHHHHCCCCH | 36.55 | 24489116 | |
| 245 | Ubiquitination | NGSEFVHKYLGEGPR CCHHHHHHHHCCCCH | 36.55 | 23749301 | |
| 280 | Ubiquitination | EVDSIATKRFDAQTG CCCCCEECCCCCCCC | 41.88 | 24961812 | |
| 337 | Ubiquitination | RPGRLDRKIEFPSLR CCCCCCCCCCCCCHH | 46.37 | 23749301 | |
| 337 | Acetylation | RPGRLDRKIEFPSLR CCCCCCCCCCCCCHH | 46.37 | 22865919 | |
| 359 | Ubiquitination | IFGTIASKMSLAPEA HHHHHHHHCCCCCCC | 24.40 | 17644757 | |
| 416 | Ubiquitination | EAYATQVKTDNTVDK HHHCCCCCCCCCCCC | 40.10 | 23749301 | |
| 423 | Succinylation | KTDNTVDKFDFYK-- CCCCCCCCCCCCC-- | 42.36 | 23954790 | |
| 423 | Ubiquitination | KTDNTVDKFDFYK-- CCCCCCCCCCCCC-- | 42.36 | 23749301 | |
| 423 | Acetylation | KTDNTVDKFDFYK-- CCCCCCCCCCCCC-- | 42.36 | 24489116 | |
| 428 | Ubiquitination | VDKFDFYK------- CCCCCCCC------- | 54.58 | 17644757 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PRS6B_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PRS6B_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PRS6B_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Acetylation | |
| Reference | PubMed |
| "Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway."; Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.; Mol. Cell. Proteomics 4:310-327(2005). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION AT THR-8,AND MASS SPECTROMETRY. | |
| "N-terminal modifications of the 19S regulatory particle subunits ofthe yeast proteasome."; Kimura Y., Saeki Y., Yokosawa H., Polevoda B., Sherman F., Hirano H.; Arch. Biochem. Biophys. 409:341-348(2003). Cited for: PROTEIN SEQUENCE OF 1-6, AND ACETYLATION AT MET-1. | |
| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-8, AND MASSSPECTROMETRY. | |
| "Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway."; Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.; Mol. Cell. Proteomics 4:310-327(2005). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION AT THR-8,AND MASS SPECTROMETRY. | |
