| UniProt ID | APE2_YEAST | |
|---|---|---|
| UniProt AC | P32454 | |
| Protein Name | Aminopeptidase 2, mitochondrial | |
| Gene Name | APE2 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 952 | |
| Subcellular Localization | Periplasm. Cytoplasm. Mitochondrion. | |
| Protein Description | Involved in the cellular supply of leucine from externally offered leucine-containing dipeptide substrates.. | |
| Protein Sequence | MPIVRWLLLKSAVRGSSLIGKAHPCLRSIAAHPRYLSNVYSPPAGVSRSLRINVMWKQSKLTPPRFVKIMNRRPLFTETSHACAKCQKTSQLLNKTPNREILPDNVVPLHYDLTVEPDFKTFKFEGSVKIELKINNPAIDTVTLNTVDTDIHSAKIGDVTSSEIISEEEQQVTTFAFPKGTMSSFKGNAFLDIKFTGILNDNMAGFYRAKYEDKLTGETKYMATTQMEPTDARRAFPCFDEPNLKASFAITLVSDPSLTHLSNMDVKNEYVKDGKKVTLFNTTPKMSTYLVAFIVAELKYVESKNFRIPVRVYATPGNEKHGQFAADLTAKTLAFFEKTFGIQYPLPKMDNVAVHEFSAGAMENWGLVTYRVVDLLLDKDNSTLDRIQRVAEVVQHELAHQWFGNLVTMDWWEGLWLNEGFATWMSWYSCNEFQPEWKVWEQYVTDTLQHALSLDSLRSSHPIEVPVKKADEINQIFDAISYSKGASLLRMISKWLGEETFIKGVSQYLNKFKYGNAKTEDLWDALADASGKDVRSVMNIWTKKVGFPVISVSEDGNGKITFRQNRYLSTADVKPDEDKTIYPVFLALKTKNGVDSSVVLSERSKTIELEDPTFFKVNSEQSGIYITSYTDERWAKLGQQADLLSVEDRVGLVADVKTLSASGYTSTTNFLNLVSKWNNEKSFVVWDQIINSISSMKSTWLFEPKETQDALDNFTKQLISGMTHHLGWEFKSSDSFSTQRLKVTMFGAACAARDADVEKAALKMFTDYCSGNKEAIPALIKPIVFNTVARVGGAENYEKVYKIYLDPISNDEKLAALRSLGRFKEPKLLERTLGYLFDGTVLNQDIYIPMQGMRAHQEGVEALWNWVKKNWDELVKRLPPGLSMLGSVVTLGTSGFTSMQKIDEIKKFFATKSTKGFDQSLAQSLDTITSKAQWVNRDRDVVNKYLKENGYY | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 133 | Ubiquitination | GSVKIELKINNPAID EEEEEEEEECCCCCE | 30.51 | 17644757 | |
| 141 | Phosphorylation | INNPAIDTVTLNTVD ECCCCCEEEEEEECC | 14.85 | 22369663 | |
| 143 | Phosphorylation | NPAIDTVTLNTVDTD CCCCEEEEEEECCCC | 19.18 | 22369663 | |
| 146 | Phosphorylation | IDTVTLNTVDTDIHS CEEEEEEECCCCCHH | 23.91 | 22369663 | |
| 149 | Phosphorylation | VTLNTVDTDIHSAKI EEEEECCCCCHHCCC | 32.30 | 22369663 | |
| 153 | Phosphorylation | TVDTDIHSAKIGDVT ECCCCCHHCCCCCCC | 31.43 | 22369663 | |
| 155 | Ubiquitination | DTDIHSAKIGDVTSS CCCCHHCCCCCCCHH | 50.68 | 17644757 | |
| 245 | Ubiquitination | CFDEPNLKASFAITL CCCCCCCEEEEEEEE | 48.93 | 17644757 | |
| 247 | Phosphorylation | DEPNLKASFAITLVS CCCCCEEEEEEEEEC | 17.39 | 22369663 | |
| 251 | Phosphorylation | LKASFAITLVSDPSL CEEEEEEEEECCCCC | 20.06 | 22369663 | |
| 254 | Phosphorylation | SFAITLVSDPSLTHL EEEEEEECCCCCCCC | 47.09 | 22369663 | |
| 257 | Phosphorylation | ITLVSDPSLTHLSNM EEEECCCCCCCCCCC | 51.39 | 22369663 | |
| 259 | Phosphorylation | LVSDPSLTHLSNMDV EECCCCCCCCCCCCC | 25.71 | 22369663 | |
| 262 | Phosphorylation | DPSLTHLSNMDVKNE CCCCCCCCCCCCCCC | 23.62 | 22369663 | |
| 320 | Acetylation | YATPGNEKHGQFAAD EECCCCCCCCCHHHH | 57.97 | 24489116 | |
| 338 | Ubiquitination | KTLAFFEKTFGIQYP HHHHHHHHHHCCCCC | 43.95 | 23749301 | |
| 348 | Ubiquitination | GIQYPLPKMDNVAVH CCCCCCCCCCCEEEE | 67.57 | 17644757 | |
| 379 | Acetylation | VVDLLLDKDNSTLDR HHHHHHCCCCCHHHH | 59.80 | 24489116 | |
| 381 | N-linked_Glycosylation | DLLLDKDNSTLDRIQ HHHHCCCCCHHHHHH | 42.51 | - | |
| 494 | Ubiquitination | SLLRMISKWLGEETF HHHHHHHHHHCCCHH | 35.20 | 23749301 | |
| 494 | Acetylation | SLLRMISKWLGEETF HHHHHHHHHHCCCHH | 35.20 | 24489116 | |
| 511 | Acetylation | GVSQYLNKFKYGNAK HHHHHHHHCCCCCCC | 40.41 | 24489116 | |
| 518 | Acetylation | KFKYGNAKTEDLWDA HCCCCCCCCHHHHHH | 57.35 | 24489116 | |
| 532 | Acetylation | ALADASGKDVRSVMN HHHHCCCCCHHHHHH | 51.02 | 24489116 | |
| 553 | Phosphorylation | GFPVISVSEDGNGKI CCEEEEEECCCCCEE | 24.15 | 27017623 | |
| 567 | Phosphorylation | ITFRQNRYLSTADVK EEEECCCEECCCCCC | 16.74 | 22369663 | |
| 569 | Phosphorylation | FRQNRYLSTADVKPD EECCCEECCCCCCCC | 16.77 | 21440633 | |
| 570 | Phosphorylation | RQNRYLSTADVKPDE ECCCEECCCCCCCCC | 25.04 | 22369663 | |
| 574 | Acetylation | YLSTADVKPDEDKTI EECCCCCCCCCCCCC | 47.50 | 24489116 | |
| 579 | Acetylation | DVKPDEDKTIYPVFL CCCCCCCCCCCEEEE | 34.47 | 24489116 | |
| 596 | Phosphorylation | KTKNGVDSSVVLSER EECCCCCCEEEEECC | 23.72 | 22369663 | |
| 597 | Phosphorylation | TKNGVDSSVVLSERS ECCCCCCEEEEECCC | 16.28 | 22369663 | |
| 604 | Phosphorylation | SVVLSERSKTIELED EEEEECCCCEEEECC | 30.05 | 22369663 | |
| 605 | Acetylation | VVLSERSKTIELEDP EEEECCCCEEEECCC | 60.80 | 24489116 | |
| 605 | Ubiquitination | VVLSERSKTIELEDP EEEECCCCEEEECCC | 60.80 | 23749301 | |
| 606 | Phosphorylation | VLSERSKTIELEDPT EEECCCCEEEECCCC | 22.41 | 22369663 | |
| 619 | Phosphorylation | PTFFKVNSEQSGIYI CCEEEECCCCCCEEE | 39.75 | 28889911 | |
| 625 | Phosphorylation | NSEQSGIYITSYTDE CCCCCCEEEEEECHH | 11.15 | 28889911 | |
| 627 | Phosphorylation | EQSGIYITSYTDERW CCCCEEEEEECHHHH | 9.94 | 28889911 | |
| 628 | Phosphorylation | QSGIYITSYTDERWA CCCEEEEEECHHHHH | 19.24 | 28889911 | |
| 629 | Phosphorylation | SGIYITSYTDERWAK CCEEEEEECHHHHHH | 15.01 | 28889911 | |
| 630 | Phosphorylation | GIYITSYTDERWAKL CEEEEEECHHHHHHH | 31.02 | 28889911 | |
| 705 | Ubiquitination | STWLFEPKETQDALD CCCCCCCCHHHHHHH | 67.22 | 17644757 | |
| 705 | Acetylation | STWLFEPKETQDALD CCCCCCCCHHHHHHH | 67.22 | 24489116 | |
| 713 | N-linked_Glycosylation | ETQDALDNFTKQLIS HHHHHHHHHHHHHHH | 47.54 | - | |
| 716 | Ubiquitination | DALDNFTKQLISGMT HHHHHHHHHHHHHCH | 38.68 | 17644757 | |
| 720 | Phosphorylation | NFTKQLISGMTHHLG HHHHHHHHHCHHHCC | 30.98 | 19823750 | |
| 723 | Phosphorylation | KQLISGMTHHLGWEF HHHHHHCHHHCCCEE | 15.07 | 19823750 | |
| 766 | Phosphorylation | KAALKMFTDYCSGNK HHHHHHHHHHHCCCH | 23.66 | 28889911 | |
| 799 | Acetylation | GGAENYEKVYKIYLD CCCCCHHHEEEEEEC | 40.27 | 24489116 | |
| 799 | Succinylation | GGAENYEKVYKIYLD CCCCCHHHEEEEEEC | 40.27 | 23954790 | |
| 802 | Acetylation | ENYEKVYKIYLDPIS CCHHHEEEEEECCCC | 28.06 | 24489116 | |
| 813 | Acetylation | DPISNDEKLAALRSL CCCCCHHHHHHHHHC | 46.41 | 24489116 | |
| 813 | Ubiquitination | DPISNDEKLAALRSL CCCCCHHHHHHHHHC | 46.41 | 24961812 | |
| 827 | Acetylation | LGRFKEPKLLERTLG CCCCCCHHHHHHHHH | 67.79 | 24489116 | |
| 868 | Ubiquitination | EALWNWVKKNWDELV HHHHHHHHHCHHHHH | 31.81 | 17644757 | |
| 869 | Acetylation | ALWNWVKKNWDELVK HHHHHHHHCHHHHHH | 54.36 | 24489116 | |
| 869 | Ubiquitination | ALWNWVKKNWDELVK HHHHHHHHCHHHHHH | 54.36 | 17644757 | |
| 876 | Acetylation | KNWDELVKRLPPGLS HCHHHHHHHCCCCHH | 61.92 | 24489116 | |
| 893 | Phosphorylation | GSVVTLGTSGFTSMQ CEEEEECCCCCCCHH | 28.87 | 19779198 | |
| 898 | Phosphorylation | LGTSGFTSMQKIDEI ECCCCCCCHHHHHHH | 19.56 | 19779198 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of APE2_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of APE2_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of APE2_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-606, AND MASSSPECTROMETRY. | |
