MRP8_YEAST - dbPTM
MRP8_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MRP8_YEAST
UniProt AC P35719
Protein Name Uncharacterized protein MRP8
Gene Name MRP8
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 219
Subcellular Localization Cytoplasm .
Protein Description
Protein Sequence MSNEIELLQKQVSELQDLVKKQSLIISKTGERVLELQLDKQKHDVTDFDSKFSKSISKKSGSATQFDATDFATNEDLVELVKELQGELNFIEERSIRRLVNSLKKDDDDVIAPLPNADGDIPAISDGVFPKSLKEFKDIPDLKLVRLAKFYERLPPTLKEQEDFENFLEGKVEAFHINETTDEEISKELEKFSKDELDDAFNDVARYLGLSLRRGTEIW
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSNEIELLQ
------CCHHHHHHH		43.0719795423
13PhosphorylationELLQKQVSELQDLVK
HHHHHHHHHHHHHHH		30.0522369663
20AcetylationSELQDLVKKQSLIIS
HHHHHHHHHCCEEEE		53.0124489116
23PhosphorylationQDLVKKQSLIISKTG
HHHHHHCCEEEECCC		30.3422369663
28AcetylationKQSLIISKTGERVLE
HCCEEEECCCCHHEE		50.5725381059
40AcetylationVLELQLDKQKHDVTD
HEEEHHCCCCCCCCC		70.6024489116
42AcetylationELQLDKQKHDVTDFD
EEHHCCCCCCCCCHH		47.7324489116
51AcetylationDVTDFDSKFSKSISK
CCCCHHHHHHHHHHH		56.3424489116
542-HydroxyisobutyrylationDFDSKFSKSISKKSG
CHHHHHHHHHHHHCC		55.74-
60PhosphorylationSKSISKKSGSATQFD
HHHHHHHCCCCCCCC		41.5422369663
62PhosphorylationSISKKSGSATQFDAT
HHHHHCCCCCCCCHH		34.9222369663
64PhosphorylationSKKSGSATQFDATDF
HHHCCCCCCCCHHHC		31.3122369663
69PhosphorylationSATQFDATDFATNED
CCCCCCHHHCCCCHH		33.2322369663
73PhosphorylationFDATDFATNEDLVEL
CCHHHCCCCHHHHHH		38.8522369663
137SumoylationPKSLKEFKDIPDLKL
CCCHHHHCCCCCHHH		56.7015166219
137SumoylationPKSLKEFKDIPDLKL
CCCHHHHCCCCCHHH		56.70-
137AcetylationPKSLKEFKDIPDLKL
CCCHHHHCCCCCHHH		56.7024489116
143AcetylationFKDIPDLKLVRLAKF
HCCCCCHHHHHHHHH		52.9324489116
1432-HydroxyisobutyrylationFKDIPDLKLVRLAKF
HCCCCCHHHHHHHHH		52.93-
180PhosphorylationEAFHINETTDEEISK
EEEEECCCCHHHHHH		34.7522369663
181PhosphorylationAFHINETTDEEISKE
EEEECCCCHHHHHHH		34.9222369663
186PhosphorylationETTDEEISKELEKFS
CCCHHHHHHHHHHCC		24.2922369663
187AcetylationTTDEEISKELEKFSK
CCHHHHHHHHHHCCH		72.4824489116
194AcetylationKELEKFSKDELDDAF
HHHHHCCHHHHHHHH		59.3524489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MRP8_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MRP8_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MRP8_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MRP8_YEASTMRP8physical
10688190
PAH1_YEASTPAH1physical
10688190
YEF3_YEASTYEL043Wphysical
16554755
YFF4_YEASTYFL054Cphysical
16554755
TRK1_YEASTTRK1physical
16554755
ELM1_YEASTELM1physical
16554755
PIL1_YEASTPIL1physical
16429126
LSP1_YEASTLSP1physical
18719252
MRP8_YEASTMRP8physical
18719252
ENO2_YEASTENO2physical
19269952
G3P3_YEASTTDH3physical
19269952
RIC1_YEASTRIC1genetic
20526336
H4_YEASTHHF1genetic
27708008
NPL4_YEASTNPL4genetic
27708008
MTU1_YEASTSLM3genetic
27708008
RLA1_YEASTRPP1Agenetic
27708008
GCS1_YEASTGCS1genetic
27708008
IES1_YEASTIES1genetic
27708008
BCK1_YEASTBCK1genetic
27708008
CYP7_YEASTCPR7genetic
27708008
RSSA2_YEASTRPS0Bgenetic
27708008
ERG3_YEASTERG3genetic
27708008
ACE2_YEASTACE2genetic
27708008
SWI6_YEASTSWI6genetic
27708008
VAM10_YEASTVAM10genetic
27708008
YME1_YEASTYME1genetic
27708008
FUMH_HUMANFHphysical
27107014
TFPT_HUMANTFPTphysical
27107014
CCDB1_HUMANCCNDBP1physical
27107014
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MRP8_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-13; SER-60 AND SER-62,AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-13, AND MASSSPECTROMETRY.
Sumoylation
ReferencePubMed
"Global analyses of sumoylated proteins in Saccharomyces cerevisiae.Induction of protein sumoylation by cellular stresses.";
Zhou W., Ryan J.J., Zhou H.;
J. Biol. Chem. 279:32262-32268(2004).
Cited for: SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-137, AND MASS SPECTROMETRY.

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