LSB6_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LSB6_YEAST
• UniProt AC: P42951
• Protein Name: Phosphatidylinositol 4-kinase LSB6
• Gene Name: LSB6
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 607
• Subcellular Localization: Cell membrane ; Peripheral membrane protein . Vacuole membrane ; Peripheral membrane protein . Located at both the plasma and vacuolar membrane.
• Protein Description: May play a role in endocytic and/or exocytic pathways..
• Protein Sequence: MSNEAYQHDHTVNPHQKIVVNSYDWLQFRDEQDHCKSKNPITHASPGVGSNAQNSDIAEAPQVFHPSYQSLVNVPSESPRPDQTSGSNPAVGLLHNAEDKASGQEEEGSQYEIQYSVFRPLHAYPTKGLAYEQLRRKEEQEQRENFNHLVSDCIEAVETFGRELERIQTGSSGSYFVYGTRADESVPVGVFKPKDEEPYGPFSPKWTKWAHRTFFPCLFGRSCLIPNLGYICESAASLLDRRLETHLVPYTDTASIESFNFYDNRKKWVLGYNLQKKKQKKLGSFQLFLKEYINADEFFHKYPLPGMYSDVKHSFHRKSSGEDINHKPETTRNLTDETEPSKQINSSPISTESEENSKFEWTESSLSQFRLELEKLIILDYIMRNTDRGLDNWMVKLIKLSNNKWRLKLAAIDNGLSFPWKHPDEWRLYPYGWLYLPLQLLAKPFSEQMRSHFLPILTSTNWWEESYQEFLALFSRDQDFNVRMWKKQWAVLKGQAFNVVETLKDPRQGPLELVRRTRCQVIDEKMQVPCCPPPVSIFKNAIDEPIGSYSTSPMVLPSTPSTIPFHAHNQSNSNPVYYDSTLHPFANKTVIAERLQIVNSTPVFTWC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSNEAYQHD ------CCCCCCCCC	43.29	29136822
169	Phosphorylation	RELERIQTGSSGSYF HHHHHCCCCCCCCEE	36.34	27214570
312	Ubiquitination	PGMYSDVKHSFHRKS CCCHHHCCHHCCCCC	38.22	24961812
319	Phosphorylation	KHSFHRKSSGEDINH CHHCCCCCCCCCCCC	43.46	29136822
320	Phosphorylation	HSFHRKSSGEDINHK HHCCCCCCCCCCCCC	49.60	29136822
335	Phosphorylation	PETTRNLTDETEPSK CCCCCCCCCCCCCCC	35.03	28889911
346	Phosphorylation	EPSKQINSSPISTES CCCCCCCCCCCCCCC	38.84	27717283
347	Phosphorylation	PSKQINSSPISTESE CCCCCCCCCCCCCCC	23.05	27717283
350	Phosphorylation	QINSSPISTESEENS CCCCCCCCCCCCCCC	29.52	27717283
351	Phosphorylation	INSSPISTESEENSK CCCCCCCCCCCCCCC	44.22	27717283
353	Phosphorylation	SSPISTESEENSKFE CCCCCCCCCCCCCCC	50.75	27717283
357	Phosphorylation	STESEENSKFEWTES CCCCCCCCCCCCCHH	41.84	27717283

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LSB6_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LSB6_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LSB6_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LAS17_YEAST	LAS17	physical	10512884
STE2_YEAST	STE2	genetic	16216926
LAS17_YEAST	LAS17	genetic	16216926
PBS2_YEAST	PBS2	genetic	20526336

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.