STE2_YEAST - dbPTM
STE2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID STE2_YEAST
UniProt AC D6VTK4
Protein Name Pheromone alpha factor receptor
Gene Name STE2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 431
Subcellular Localization Membrane
Multi-pass membrane protein.
Protein Description Receptor for the peptide pheromone alpha factor, the mating factor of yeast..
Protein Sequence MSDAAPSLSNLFYDPTYNPGQSTINYTSIYGNGSTITFDELQGLVNSTVTQAIMFGVRCGAAALTLIVMWMTSRSRKTPIFIINQVSLFLIILHSALYFKYLLSNYSSVTYALTGFPQFISRGDVHVYGATNIIQVLLVASIETSLVFQIKVIFTGDNFKRIGLMLTSISFTLGIATVTMYFVSAVKGMIVTYNDVSATQDKYFNASTILLASSINFMSFVLVVKLILAIRSRRFLGLKQFDSFHILLIMSCQSLLVPSIIFILAYSLKPNQGTDVLTTVATLLAVLSLPLSSMWATAANNASKTNTITSDFTTSTDRFYPGTLSSFQTDSINNDAKSSLRSRLYDLYPRRKETTSDKHSERTFVSETADDIEKNQFYQLPTPTSSKNTRIGPFADASYKEGEVEPVDMYTPDTAADEEARKFWTEDNNNL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
25N-linked_GlycosylationNPGQSTINYTSIYGN
CCCCCEEEEEEEECC		33.8311583169
32N-linked_GlycosylationNYTSIYGNGSTITFD
EEEEEECCCCEEEHH		25.0311583169
192PhosphorylationAVKGMIVTYNDVSAT
HHCCEEEEECCCCCC		12.9928889911
193PhosphorylationVKGMIVTYNDVSATQ
HCCEEEEECCCCCCC		9.8528889911
197PhosphorylationIVTYNDVSATQDKYF
EEEECCCCCCCCCCC		28.5828889911
199PhosphorylationTYNDVSATQDKYFNA
EECCCCCCCCCCCCH		29.7828889911
305PhosphorylationAANNASKTNTITSDF
HCCCCCCCCCCCCCC		34.7922369663
307PhosphorylationNNASKTNTITSDFTT
CCCCCCCCCCCCCCC		30.7522369663
309PhosphorylationASKTNTITSDFTTST
CCCCCCCCCCCCCCC		21.8722369663
310PhosphorylationSKTNTITSDFTTSTD
CCCCCCCCCCCCCCC		27.2022369663
313PhosphorylationNTITSDFTTSTDRFY
CCCCCCCCCCCCCCC		25.4822369663
314PhosphorylationTITSDFTTSTDRFYP
CCCCCCCCCCCCCCC		29.6222369663
315PhosphorylationITSDFTTSTDRFYPG
CCCCCCCCCCCCCCC		25.8322369663
316PhosphorylationTSDFTTSTDRFYPGT
CCCCCCCCCCCCCCC		29.1522369663
320PhosphorylationTTSTDRFYPGTLSSF
CCCCCCCCCCCCHHC		11.1422890988
323PhosphorylationTDRFYPGTLSSFQTD
CCCCCCCCCHHCCCC		20.9722890988
325PhosphorylationRFYPGTLSSFQTDSI
CCCCCCCHHCCCCCC		29.0122890988
326PhosphorylationFYPGTLSSFQTDSIN
CCCCCCHHCCCCCCC		25.2022890988
329PhosphorylationGTLSSFQTDSINNDA
CCCHHCCCCCCCCCH		29.6922369663
331PhosphorylationLSSFQTDSINNDAKS
CHHCCCCCCCCCHHH		30.5122369663
337UbiquitinationDSINNDAKSSLRSRL
CCCCCCHHHHHHHHH		43.3623749301
338PhosphorylationSINNDAKSSLRSRLY
CCCCCHHHHHHHHHH		36.0019684113
339PhosphorylationINNDAKSSLRSRLYD
CCCCHHHHHHHHHHH		27.3923749301
342PhosphorylationDAKSSLRSRLYDLYP
CHHHHHHHHHHHHCC		31.7519828733
354PhosphorylationLYPRRKETTSDKHSE
HCCCCCCCCCCCHHC		34.3419823750
355PhosphorylationYPRRKETTSDKHSER
CCCCCCCCCCCHHCC		35.7019823750
356PhosphorylationPRRKETTSDKHSERT
CCCCCCCCCCHHCCE		52.6719823750
360PhosphorylationETTSDKHSERTFVSE
CCCCCCHHCCEEEEC		34.2217330950
363PhosphorylationSDKHSERTFVSETAD
CCCHHCCEEEECCHH		25.0817330950
366PhosphorylationHSERTFVSETADDIE
HHCCEEEECCHHHHH		25.6622369663
368PhosphorylationERTFVSETADDIEKN
CCEEEECCHHHHHHC		28.0722890988
374UbiquitinationETADDIEKNQFYQLP
CCHHHHHHCCCCCCC		57.2823749301
378PhosphorylationDIEKNQFYQLPTPTS
HHHHCCCCCCCCCCC		10.2022890988
382PhosphorylationNQFYQLPTPTSSKNT
CCCCCCCCCCCCCCC		48.0322369663
384PhosphorylationFYQLPTPTSSKNTRI
CCCCCCCCCCCCCCE		48.3822369663
385PhosphorylationYQLPTPTSSKNTRIG
CCCCCCCCCCCCCEE		40.2822369663
386PhosphorylationQLPTPTSSKNTRIGP
CCCCCCCCCCCCEEC		32.1922369663
387UbiquitinationLPTPTSSKNTRIGPF
CCCCCCCCCCCEECC		63.2023749301
389PhosphorylationTPTSSKNTRIGPFAD
CCCCCCCCCEECCCC		27.6625704821
398PhosphorylationIGPFADASYKEGEVE
EECCCCCCCCCCCEE		36.9722369663
399PhosphorylationGPFADASYKEGEVEP
ECCCCCCCCCCCEEE		18.1222890988
400UbiquitinationPFADASYKEGEVEPV
CCCCCCCCCCCEEEC		57.6623749301
410PhosphorylationEVEPVDMYTPDTAAD
CEEECCCCCCCCCCH		15.6222890988
411PhosphorylationVEPVDMYTPDTAADE
EEECCCCCCCCCCHH		14.1917330950
414PhosphorylationVDMYTPDTAADEEAR
CCCCCCCCCCHHHHH		25.5817330950
422UbiquitinationAADEEARKFWTEDNN
CCHHHHHHHHCCCCC		52.9123749301
425PhosphorylationEEARKFWTEDNNNL-
HHHHHHHCCCCCCC-		36.278524302
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
-KUbiquitinationE3 ubiquitin ligaseRSP5P39940
PMID:22199232
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of STE2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of STE2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
STE2_YEASTSTE2physical
10982387
STE2_YEASTSTE2physical
15352875
GBB_YEASTSTE4physical
10664449
GPA1_YEASTGPA1physical
10664449
GBB_YEASTSTE4genetic
2104659
STE5_YEASTSTE5genetic
8289786
AXL1_YEASTAXL1genetic
10398345
SOP4_YEASTSOP4genetic
12230471
SST2_YEASTSST2genetic
10485282
STE12_YEASTSTE12genetic
2193847
AFR1_YEASTAFR1genetic
9504911
SST2_YEASTSST2genetic
1653030
GBB_YEASTSTE4genetic
2107073
GBB_YEASTSTE4genetic
7796906
STE3_YEASTSTE3physical
17369365
STE12_YEASTSTE12genetic
9286665
SST2_YEASTSST2genetic
3037311
SEC6_YEASTSEC6physical
18467557
STE2_YEASTSTE2physical
19839649
STP22_YEASTSTP22genetic
10207082
GEF1_YEASTGEF1genetic
10207082
VPS8_YEASTVPS8genetic
10207082
VPS28_YEASTVPS28genetic
10207082
VPS10_YEASTPEP1genetic
10207082
VPS1_YEASTVPS1genetic
10207082
MFAL1_YEASTMF(ALPHA)1physical
20923758
RCC1_YEASTSRM1genetic
2548085
STE2_YEASTSTE2physical
22268895
STE2_YEASTSTE2physical
22923047
STE2_YEASTSTE2physical
24122388
STE2_YEASTSTE2physical
24682008
ROD1_YEASTROD1physical
24820415
ROG3_YEASTROG3physical
24820415
LDB19_YEASTLDB19physical
24820415
STE2_YEASTSTE2physical
25157670
STE5_YEASTSTE5genetic
19746161
STE7_YEASTSTE7genetic
19746161
STE2_YEASTSTE2physical
27993568
STE2_YEASTSTE2physical
28073700
ROD1_YEASTROD1genetic
26920760
ROG3_YEASTROG3genetic
26920760
GPA1_YEASTGPA1physical
28958779
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of STE2_YEAST

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Related Literatures of Post-Translational Modification
N-linked Glycosylation
ReferencePubMed
"Mutational analysis of the role of N-glycosylation in alpha-factorreceptor function.";
Mentesana P.E., Konopka J.B.;
Biochemistry 40:9685-9694(2001).
Cited for: GLYCOSYLATION AT ASN-25 AND ASN-32.
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-382; SER-386 ANDSER-398, AND MASS SPECTROMETRY.
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-366, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-310; THR-329; SER-331;SER-360; THR-363; SER-366; THR-382; SER-385; SER-386; THR-411 ANDTHR-414, AND MASS SPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-366 AND THR-382, ANDMASS SPECTROMETRY.
"Phosphoproteome analysis by mass spectrometry and its application toSaccharomyces cerevisiae.";
Ficarro S.B., McCleland M.L., Stukenberg P.T., Burke D.J., Ross M.M.,Shabanowitz J., Hunt D.F., White F.M.;
Nat. Biotechnol. 20:301-305(2002).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-382; THR-384; SER-385;THR-411 AND THR-414, AND MASS SPECTROMETRY.

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