STE3_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STE3_YEAST
• UniProt AC: P06783
• Protein Name: Pheromone a factor receptor
• Gene Name: STE3
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 470
• Subcellular Localization: Membrane; Multi-pass membrane protein.
• Protein Description: Receptor for the peptide pheromone a factor..
• Protein Sequence: MSYKSAIIGLCLLAVILLAPPLAWHSHTKNIPAIILITWLLTMNLTCIVDAAIWSDDDFLTRWDGKGWCDIVIKLQVGANIGISCAVTNIIYNLHTILKADSVLPDLSSWTKIVKDLVISLFTPVMVMGFSYLLQVFRYGIARYNGCQNLLSPTWITTVLYTMWMLIWSFVGAVYATLVLFVFYKKRKDVRDILHCTNSGLNLTRFARLLIFCFIIILVMFPFSVYTFVQDLQQVEGHYTFKNTHSSTIWNTIIKFDPGRPIYNIWLYVLMSYLVFLIFGLGSDALHMYSKFLRSIKLGFVLDMWKRFIDKNKEKRVGILLNKLSSRKESRNPFSTDSENYISTCTENYSPCVGTPISQAHFYVDYRIPDDPRKSQNKSKKYLFADKETDDILDEIDLKESRHIPYVTQGQSFDDEISLGGFSKVTLDYSEKLHNSASSNFEGESLCYSPASKEENSSSNEHSSENTAGP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
108	Phosphorylation	DSVLPDLSSWTKIVK CCCCCCHHHHHHHHH	31.07	21440633
111	Phosphorylation	LPDLSSWTKIVKDLV CCCHHHHHHHHHHHH	16.91	21440633
323	Acetylation	RVGILLNKLSSRKES HHHHHHHHHHCCCHH	50.11	24489116
323	Ubiquitination	RVGILLNKLSSRKES HHHHHHHHHHCCCHH	50.11	24961812
375	Phosphorylation	IPDDPRKSQNKSKKY CCCCCCCCCCCCCCE	40.02	25005228
387	Ubiquitination	KKYLFADKETDDILD CCEEECCCCCCCCHH	60.11	24961812
399	Ubiquitination	ILDEIDLKESRHIPY CHHHCCCCHHCCCCE	50.31	24961812
408	Phosphorylation	SRHIPYVTQGQSFDD HCCCCEECCCCCCCC	22.57	30377154
412	Phosphorylation	PYVTQGQSFDDEISL CEECCCCCCCCCCCC	37.15	21440633
418	Phosphorylation	QSFDDEISLGGFSKV CCCCCCCCCCCCEEE	20.93	21440633
424	Ubiquitination	ISLGGFSKVTLDYSE CCCCCCEEEEEECHH	36.66	-
426	Phosphorylation	LGGFSKVTLDYSEKL CCCCEEEEEECHHHH	20.04	21440633
430	Phosphorylation	SKVTLDYSEKLHNSA EEEEEECHHHHHCCC	28.11	25521595
432	Ubiquitination	VTLDYSEKLHNSASS EEEECHHHHHCCCCC	49.45	-
436	Phosphorylation	YSEKLHNSASSNFEG CHHHHHCCCCCCCCC	20.84	20377248
438	Phosphorylation	EKLHNSASSNFEGES HHHHCCCCCCCCCCC	26.15	20377248
439	Phosphorylation	KLHNSASSNFEGESL HHHCCCCCCCCCCCC	45.30	20377248
445	Phosphorylation	SSNFEGESLCYSPAS CCCCCCCCCCCCCCC	34.30	20377248
449	Phosphorylation	EGESLCYSPASKEEN CCCCCCCCCCCCCCC	17.00	21551504
452	Phosphorylation	SLCYSPASKEENSSS CCCCCCCCCCCCCCC	43.94	20377248
453	Ubiquitination	LCYSPASKEENSSSN CCCCCCCCCCCCCCC	71.76	-
458	Phosphorylation	ASKEENSSSNEHSSE CCCCCCCCCCCCCCC	49.08	21551504
464	Phosphorylation	SSSNEHSSENTAGP- CCCCCCCCCCCCCC-	36.45	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of STE3_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STE3_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STE3_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AKR1_YEAST	AKR1	physical	9243510
GBB_YEAST	STE4	genetic	2104659
RCC1_YEAST	SRM1	genetic	2548085
ASG7_YEAST	ASG7	genetic	11073982
STE20_YEAST	STE20	genetic	8754848
PEX15_YEAST	PEX15	physical	16093310

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-430, AND MASSSPECTROMETRY.
PubMed: 18407956